Results 81 to 90 of about 175,061 (321)

Unwrapping the Ciliary Coat: High‐Resolution Structure and Function of the Ciliary Glycocalyx

Advanced Science, EarlyView.
The ciliary membrane is decorated in glycosylated proteins that define the interaction of the cilium with its environment. The main component of the ciliary coat of the green alga Chlamydomonas reinhardtii, FMG1, is characterized by cryo‐electron microscopy, proteomics, and live cell microscopy with flow‐based adhesion assays.
Lara M. Hoepfner, Adrian P. Nievergelt, Fabrizio Matrino, Martin Scholz, Helen E. Foster, Jonathan Rodenfels, Alexander von Appen, Michael Hippler, Gaia Pigino   +8 more
wiley   +1 more source

Congenital protein hypoglycosylation diseases

The Application of Clinical Genetics, 2012
Susan E SparksDepartment of Pediatrics, Levine Children's Hospital at Carolinas Medical Center, Charlotte, NC, USA; Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USAAbstract: Glycosylation is an ...
Sparks SE
doaj  

Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels

Frontiers in Endocrinology, 2011
The thrombopoietin receptor (TpoR) is a type I transmembrane protein that mediates the signaling functions of thrombopoietin (Tpo) in regulating megakaryocyte differentiation, platelet formation and hematopoietic stem cell renewal.
Roxana I. Albu, Stefan N. eConstantinescu   +1 more
doaj   +1 more source

SENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De‐SUMOylation of CTH

Advanced Science, EarlyView.
In this study, it is proposed that SENP3 accumulates in macrophages of aneurysmal aortic tissues, which promotes macrophage ferroptosis and inflammation via regulation of CTH de‐SUMOylation. Abstract Abdominal aortic aneurysm (AAA) is a high‐risk inflammatory disorder. SENP3, a SUMO2/3‐specific protease, is closely involved in the development of cancer.
Long Chen, Zhaohua Cai, Danrui Xiao, Yiping Shi, Qingqing Xiao, Min Liang, Yangjing Jiang, Yijie Huang, Feng Liang, Guo Zhou, Fei Zhuang, Xia Wang, Huanhuan Huo, Liang Fang, Qin Shao, Ben He   +15 more
wiley   +1 more source

N-glycosylation of the protein disulfide isomerase Pdi1 ensures full Ustilago maydis virulence.

PLoS Pathogens, 2019
Fungal pathogenesis depends on accurate secretion and location of virulence factors which drive host colonization. Protein glycosylation is a common posttranslational modification of cell wall components and other secreted factors, typically required for
Miriam Marín-Menguiano, Ismael Moreno-Sánchez, Ramón R Barrales, Alfonso Fernández-Álvarez, José Ignacio Ibeas   +4 more
doaj   +1 more source

Computationally Discovered Potentiating Role of Glycans on NMDA Receptors [PDF]

arXiv, 2016
N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate these effects.
arxiv  

Glucose values prediction five years ahead with a new framework of missing responses in reproducing kernel Hilbert spaces, and the use of continuous glucose monitoring technology [PDF]

arXiv, 2020
AEGIS study possesses unique information on longitudinal changes in circulating glucose through continuous glucose monitoring technology (CGM). However, as usual in longitudinal medical studies, there is a significant amount of missing data in the outcome variables.
arxiv  

A New Strategy to Functionalize Exosomes via Enzymatic Engineering of Surface Glycans and its Application to Profile Exosomal Glycans and Endocytosis

Advanced Science, EarlyView.
Enzymatic introduction of azido‐sialic acid residues to the glycans on exosomes enables a new and efficient approach for exosomal functionalization with various probes, including biotin and fluorophores, by biocompatible click chemistry, thereby facilitating detailed investigations of exosomes, such as their glycan profiles, cellular uptake, etc., and ...
Sayan Kundu, Jiatong Guo, Md. Shamiul Islam, Rajendra Rohokale, Mohit Jaiswal, Zhongwu Guo   +5 more
wiley   +1 more source

Single-Molecule Lamellar Hydrogels from Bolaform Microbial Glucolipids [PDF]

, 2019
Lipid lamellar hydrogels are rare soft fluids composed of a phospholipid lamellar phase instead of fibrillar networks. The mechanical properties of these materials are controlled by defects, induced by local accumulation of a polymer or surfactant in a classical lipid bilayer.
arxiv   +1 more source

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source