Results 81 to 90 of about 191,408 (290)

Glycosylation in neuroinflammation: mechanisms, implications, and therapeutic strategies for neurodegenerative diseases

Translational Neurodegeneration
Neuroinflammation is a key pathological mechanism underlying neurodegenerative diseases, and intricately interacts with protein glycosylation. Emerging evidence suggests that aberrant glycosylation disrupts immune homeostasis, activates microglia, and ...
Shenglan Cheng, Bo Xiao, Zhaohui Luo
doaj   +1 more source

Glycosylation of oral bacteria in modulating adhesion and biofilm formation

Journal of Oral Microbiology
Background Glycosylation is a ubiquitous biochemical process that covalently attaches glycans to proteins or lipids, which plays a pivotal role in modulating the structure and function of these biomolecules.
Simeng Yi, Yingyu Liu, Qinrui Wu, Danning Zhao, Zhengyi Li, Xian Peng, Ga Liao, Shida Wang   +7 more
doaj   +1 more source

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation [PDF]

, 2015
Michelle Hung, Joshua N. Leonard
openalex   +1 more source

Ig Glycosylation in Ulcerative Colitis: It’s Time for New Biomarkers [PDF]

, 2021
Riccardo Capecchi, Paola Migliorini, Federico Zanzi, S. Maltinti, Ilaria Puxeddu, Nicola de Bortoli, Massimo Bellini, Francesco Costa, Santino Marchi, Lorenzo Bertani   +9 more
openalex   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

N- and O-glycan analysis for the detection of glycosylation disorders [PDF]

, 2021
Amr S. Gouda, Azza Fahmy Elbaz, Thierry Dupré, Ola Ali, Maha S. Zaki, Ekram Fateen   +5 more
openalex   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins [PDF]

, 2014
Н. А. Черепанова, Shiteshu Shrimal, Reid Gilmore   +2 more
openalex   +1 more source

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source