Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells [PDF]
eLife, 2017 The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion.
Michiel van Veen +11 more
doaj +4 more sources
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex [PDF]
Advanced ScienceThe glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. As a key component of this pathway, GPI transamidase (GPIT) catalyzes the attachment of GPI anchors to proteins, a process essential for fungal cell ...
Zhengkang Hua +12 more
doaj +2 more sources
Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels[S] [PDF]
Journal of Lipid Research, 2012 Glycosylphosphatidylinositol (GPI) anchor biosynthesis takes place in the endoplasmic reticulum (ER). After protein attachment, the GPI anchor is transported to the Golgi where it undergoes fatty acid remodeling.
Ursula Loizides-Mangold +4 more
doaj +5 more sources
Endocytosis of glycosylphosphatidylinositol-anchored proteins [PDF]
Journal of Biomedical Science, 2009 Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids.
Sabharanjak Shefali +2 more
doaj +3 more sources
Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes
mSphere, 2022 A hallmark of eukaryotic cells is the ability to form a secretory pathway connecting many intracellular compartments. In the early secretory pathway, coated protein complex II (COPII)-coated vesicles mediate the anterograde transport of newly synthesized
Mohamed Sharif, James D. Bangs
doaj +1 more source
Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides [PDF]
ACS Chemical Biology, 2021 The attachment of proteins to the cell membrane using a glycosylphosphatidylinositol (GPI) anchor is a ubiquitous process in eukaryotic cells. Deficiencies in the biosynthesis of GPIs and the concomitant production of GPI-anchored proteins lead to a series of rare and complicated disorders associated with inherited GPI deficiencies (IGDs) in humans ...
Paula A. Guerrero +5 more
openaire +3 more sources
Biosynthesis and biology of mammalian GPI-anchored proteins [PDF]
Open Biology, 2020 At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus.
Taroh Kinoshita
doaj +1 more source
Glycosylphosphatidylinositol-Anchor Synthesis in Plants: A Glycobiology Perspective
Frontiers in Plant Science, 2020 More than 200 diverse secretory proteins from Arabidopsis thaliana carry a glycosylphosphatidylinositol (GPI) lipid anchor covalently attached to their carboxyl-terminus.
Gernot Beihammer +3 more
doaj +1 more source
Turnover of Variant Surface Glycoprotein in
mBio, 2021 African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific phospholipase C (
Paige Garrison +9 more
doaj +1 more source
Trypanosome Glycosylphosphatidylinositol Biosynthesis [PDF]
The Korean Journal of Parasitology, 2009 Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins.
Yeonchul, Hong, Taroh, Kinoshita
openaire +2 more sources