Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
Summary: CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated macrophages, providing a “don’t eat me” signal that prevents targeting and phagocytosis by ...
Alok K. Mishra +19 more
doaj +1 more source
Structural insights into the inhibition mechanism of fungal GWT1 by manogepix
Glycosylphosphatidylinositol (GPI) acyltransferase is crucial for the synthesis of GPI-anchored proteins. Targeting the fungal glycosylphosphatidylinositol acyltransferase GWT1 by manogepix is a promising antifungal strategy.
Xinli Dai +8 more
doaj +1 more source
Glycosylphosphatidylinositols of Protozoan Parasites
Tsai, Y. +3 more
openaire +3 more sources
Fatimah Al-Ani,1 Ian Chin-Yee,1 Alejandro Lazo-Langner1,2 1Department of Medicine, Division of Hematology, 2Department of Epidemiology and Biostatistics, Western University, London, ON, Canada Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a ...
Al-Ani F, Chin-Yee I, Lazo-Langner A
doaj
Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer. [PDF]
Yang YF +4 more
europepmc +1 more source
Membrane Association of Lipoprotein Lipase and a cAMP-Binding Ectoprotein in Rat Adipocytes [PDF]
Bandlow, Wolfhard +3 more
core +1 more source
Case report: Spontaneous remission of severe aplastic anemia mediated by mutant hematopoietic stem cells evading T-cell attack. [PDF]
Shiroshita K +10 more
europepmc +1 more source
Structural Insights into the Glycosylphosphatidylinositol Mannosyltransferase I Complex from <i>Candida glabrata</i>. [PDF]
Sun H +6 more
europepmc +1 more source

