Results 21 to 30 of about 42,851 (291)
Protein O-Fucosyltransferase 1 Undergoes Interdomain Flexibility in Solution
Molecules, 2021 Protein O-fucosyltransferase 1 (PoFUT1) is a GT-B fold enzyme that fucosylates proteins containing EGF-like repeats. GT-B glycosyltransferases have shown a remarkable grade of plasticity adopting closed and open conformations as a way of tuning their ...
Erandi Lira-Navarrete +6 more
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Frontiers in Microbiology, 2016 The enzyme subclass of glycosyltransferases (EC 2.4) currently comprises 97 families as specified by CAZy classification. One of their important roles is in the biosynthesis of disaccharides, oligosaccharides and polysaccharides by catalyzing the ...
Jochen eSchmid +4 more
doaj +1 more source
Glycobiology of the Epithelial to Mesenchymal Transition
Biomedicines, 2021 Glycosylation consists in the covalent, enzyme mediated, attachment of sugar chains to proteins and lipids. A large proportion of membrane and secreted proteins are indeed glycoproteins, while glycolipids are fundamental component of cell membranes.
Michela Pucci +2 more
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A seed-specific regulator of triterpene saponin biosynthesis in Medicago truncatula [PDF]
, 2020 Plants produce a vast array of defense compounds to protect themselves from pathogen attack or herbivore predation. Saponins are a specific class of defense compounds comprising bioactive glycosides with a steroidal or triterpenoid aglycone backbone. The
Arendt, Philipp +11 more
core +2 more sources
Effector Glycosyltransferases in Legionella [PDF]
Frontiers in Microbiology, 2011 Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2 and Lgt3 from L. pneumophila. Lgt1 and Lgt2 are produced predominately in the post-exponential phase of bacterial growth, while synthesis of Lgt3 is induced mainly in the
Belyi, Yury +2 more
openaire +4 more sources
Mucin-Type O-Glycosylation in Gastric Carcinogenesis
Biomolecules, 2016 Mucin-type O-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. Modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their ...
Henrique O. Duarte +5 more
doaj +1 more source
Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells [PDF]
, 2015 Protein O-glycosylation has key roles in many biological processes, but the repertoire of O-glycans synthesized by cells is difficult to determine. Here we describe an approach termed Cellular O-Glycome Reporter/Amplification (CORA), a sensitive method ...
Antonopoulos, A +9 more
core +1 more source
The Suitability of Orthogonal Hosts to Study Plant Cell Wall Biosynthesis
Plants, 2019 Plant cells are surrounded by an extracellular matrix that consists mainly of polysaccharides. Many molecular components involved in plant cell wall polymer synthesis have been identified, but it remains largely unknown how these molecular players ...
Markus Pauly +6 more
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Filling the Gaps to Solve the Extensin Puzzle [PDF]
, 2018 Extensins (EXTs) are highly repetitive plant O-glycoproteins that require several post-translational modifications (PTMs) to become functional in plant cell walls.
Borassi, Cecilia +6 more
core +1 more source
Polysaccharide Biosynthesis: Glycosyltransferases and Their Complexes
Frontiers in Plant Science, 2021 Glycosyltransferases (GTs) are enzymes that catalyze reactions attaching an activated sugar to an acceptor substrate, which may be a polysaccharide, peptide, lipid, or small molecule.
Olga A. Zabotina +2 more
doaj +1 more source