Results 11 to 20 of about 22,975 (220)

Effector Glycosyltransferases in Legionella [PDF]

Frontiers in Microbiology, 2011
Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2 and Lgt3 from L. pneumophila. Lgt1 and Lgt2 are produced predominately in the post-exponential phase of bacterial growth, while synthesis of Lgt3 is induced mainly in the
Belyi, Yury, Jank, Thomas, Aktories, Klaus   +2 more
openaire   +4 more sources

METTL7A Downregulation Drives SLC1A5-Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8⁺ T Cell Immunity in Gastric Cancer. [PDF]

Adv Sci (Weinh)
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Sun M, Dang S, Zhou D, Ding L, Sun X, Suo W, Niu J, Yang Q, Zhang Z, Sun Y, Li J, Chen Z, Ban T, Wang Y, Li T, Liu M, Li G.   +16 more
europepmc   +2 more sources

Bacterial Glycosyltransferases: Challenges and opportunities of a highly diverse enzyme class toward tailoring natural products

Frontiers in Microbiology, 2016
The enzyme subclass of glycosyltransferases (EC 2.4) currently comprises 97 families as specified by CAZy classification. One of their important roles is in the biosynthesis of disaccharides, oligosaccharides and polysaccharides by catalyzing the ...
Jochen eSchmid, Dominik eHeider, Norma J. Wendel, Nadine eSperl, Volker eSieber   +4 more
doaj   +1 more source

Mucin-Type O-Glycosylation in Gastric Carcinogenesis

Biomolecules, 2016
Mucin-type O-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. Modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their ...
Henrique O. Duarte, Daniela Freitas, Catarina Gomes, Joana Gomes, Ana Magalhães, Celso A. Reis   +5 more
doaj   +1 more source

Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression

Frontiers in Oncology, 2021
Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix (ECM) maestros involved in the orchestration of multiple cellular events in physiology and pathology.
Catarina Marques, Catarina Marques, Catarina Marques, Celso A. Reis, Celso A. Reis, Celso A. Reis, Celso A. Reis, Romain R. Vivès, Ana Magalhães, Ana Magalhães, Ana Magalhães   +10 more
doaj   +1 more source

The Suitability of Orthogonal Hosts to Study Plant Cell Wall Biosynthesis

Plants, 2019
Plant cells are surrounded by an extracellular matrix that consists mainly of polysaccharides. Many molecular components involved in plant cell wall polymer synthesis have been identified, but it remains largely unknown how these molecular players ...
Markus Pauly, Niklas Gawenda, Christine Wagner, Patrick Fischbach, Vicente Ramírez, Ilka M. Axmann, Cătălin Voiniciuc   +6 more
doaj   +1 more source

Putative hexameric glycosyltransferase functional unit revealed by the crystal structure of Acinetobacter baumannii MurG

IUCrJ, 2021
Lipid II, the main component of the bacterial cell wall, is synthesized by the addition of UDP-N-acetylglucosamine to the UDP-N-acetylmuramic acid pentapeptide catalyzed by the glycosyltransferase MurG.
Kyoung Ho Jung, Sunghark Kwon, Chang Min Kim, Jun Hyuck Lee, Hyun Ho Park   +4 more
doaj   +1 more source

Polar Flagella Glycosylation in Aeromonas: Genomic Characterization and Involvement of a Specific Glycosyltransferase (Fgi-1) in Heterogeneous Flagella Glycosylation

Frontiers in Microbiology, 2021
Polar flagella from mesophilic Aeromonas strains have previously been shown to be modified with a range of glycans. Mass spectrometry studies of purified polar flagellins suggested the glycan typically includes a putative pseudaminic acid like derivative;
Gabriel Forn-Cuní, Kelly M. Fulton, Kelly M. Fulton, Jeffrey C. Smith, Susan M. Twine, Susan M. Twine, Elena Mendoza-Barberà, Juan M. Tomás, Susana Merino   +8 more
doaj   +1 more source

Glycosyltransferases Expression Changes in Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Grown on Different Carbon Sources

Foods, 2023
Leuconostoc mesenteroides strains are common contributors in fermented foods producing a wide variety of polysaccharides from sucrose through glycosyltransferases (GTFs).
Luz Cristina Vallejo-García, María del Carmen Sánchez-Olmos, Rosa María Gutiérrez-Ríos, Agustín López Munguía   +3 more
doaj   +1 more source

High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan

Open Biology, 2021
The dystroglycan (DG) complex plays a pivotal role for the stabilization of muscles in Metazoa. It is formed by two subunits, extracellular α-DG and transmembrane β-DG, originating from a unique precursor via a complex post-translational maturation ...
Maria Giulia Bigotti, Andrea Brancaccio
doaj   +1 more source