Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma. [PDF]
, 2016 Several immunomodulatory checkpoint inhibitors have been approved for the treatment of patients with advanced melanoma, including ipilimumab, nivolumab and pembrolizumab.
Ascierto, P.A. +4 more
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Frontiers in Pediatrics, 2021 Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pro-inflammatory cytokine that is increased in the amniotic fluid in chorioamnionitis and elevated in the fetal lung with endotoxin exposure. Although GM-CSF has a pivotal role in
Fook-Choe Cheah +6 more
doaj +1 more source
Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family [PDF]
, 1998 The receptors for the Il-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric com-plex of a cytokine-specific a chain and a common ß chain (ßc).
Coffer, P.J. +2 more
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Frontiers in Immunology, 2019 Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs)
Yifan Zhan +6 more
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Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes [PDF]
, 2020 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine that prompts the proliferation of bone marrow-derived macrophages and granulocytes.
Esmaeil, Nafiseh +3 more
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Increasing the Inflammatory Competence of Macrophages with IL-6 or with Combination of IL-4 and LPS Restrains the Invasiveness of Pancreatic Cancer Cells [PDF]
, 2016 Recent studies suggest that pro-inflammatory type M1 macrophages inhibit tumor progression and that anti-inflammatory M2 macrophages enhance it. The aim of this study was to examine the interaction of type M1 and M2 macrophages with pancreatic cancer ...
Kemppainen, Esko A. J. +6 more
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Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival [PDF]
, 2012 We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a panel of commercially available small molecule isoform-selective PI3K Class I inhibitors, (ii ...
Alison M. Condliffe +12 more
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In vivo application of Granulocyte-Macrophage Colony-stimulating Factor enhances postoperative qualitative monocytic function [PDF]
, 2017 BACKGROUND: Granulocyte macrophage colony-stimulating factor (GM-CSF) can be used as a potent stimulator for immune suppressed patients as defined by a decrease of human leukocyte antigen-D related expression on monocytes (mHLA- DR) after surgery ...
Kurth, Johannes +5 more
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Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies
Frontiers in Immunology, 2020 COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that often leads to respiratory failure, need for mechanical ventilation, and death.
Aldo Bonaventura +16 more
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Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis [PDF]
, 2015 Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection,
Ali, Muhammad +13 more
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