Results 61 to 70 of about 19,645 (252)

GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP

Biomedicines, 2023
Past evidence has shown that the exogenous administration of GM1 ganglioside slowed neuronal death in preclinical models of Parkinson’s disease, a neurodegenerative disorder characterized by the progressive loss of dopamine-producing neurons: however ...
Maria Fazzari, Giulia Lunghi, Alexandre Henriques, Noëlle Callizot, Maria Grazia Ciampa, Laura Mauri, Simona Prioni, Emma Veronica Carsana, Nicoletta Loberto, Massimo Aureli, Luigi Mari, Sandro Sonnino, Elena Chiricozzi, Erika Di Biase   +13 more
doaj   +1 more source

Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]

, 2019
Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi, Kooner, Anoopjit Singh, Yu, Hai   +2 more
core   +2 more sources

Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model

The Journal of Clinical Investigation, 2022
In Guillain-Barré syndrome (GBS), both axonal and demyelinating variants can be mediated by complement-fixing anti–GM1 ganglioside autoantibodies that target peripheral nerve axonal and Schwann cell (SC) membranes, respectively. Critically, the extent of
Rhona McGonigal, Clare I. Campbell, Jennifer A. Barrie, Denggao Yao, Madeleine E. Cunningham, Colin L. Crawford, Simon Rinaldi, Edward G. Rowan, Hugh J. Willison   +8 more
doaj   +1 more source

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson\u27s Disease. [PDF]

, 2019
While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated.
Aras, Radha, Brotchie, Jonathan M., Koprich, James B., Schneider, Jay S., Singh, Vikrant, Williams, Courtney K.   +5 more
core   +1 more source

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

Neuromuscular synaptic transmission in aged ganglioside-deficient mice [PDF]

, 2011
Gangliosides are sialylated glycosphingolipids that are present in high density on neuronal membranes, especially at synapses, where they are assumed to play functional or modulating roles.
Furukawa, K., Furukawa, K., Jacobs, B.C., Plomp, J.J., Todorov, B., Verschuuren, J.J., Willison, H.J., Zitman, F.M.P.   +7 more
core   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Astrocytes in cell culture incorporate GM1 ganglioside [PDF]

Glia, 1989
AbstractGanglioside GM1 3H‐labelled at the terminal galactose was added to astrocyte cell cultures. GM1 incorporation was studied in the two typical forms of astrocytes in cell culture of flat and stellate morphology. There was a strong time‐ and concentration‐dependent increase in GM1 incorporation for both cell types of astrocytes.
Masco, D., Flott, B., Seifert, W.
openaire   +3 more sources

Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide. [PDF]

PLoS ONE, 2014
A broad range of microbial and amyloid proteins interact with cell surface glycolipids which behave as infectivity and/or toxicity cofactors in human pathologies.
Nouara Yahi, Jacques Fantini
doaj   +1 more source

Increased Circulating T Cell Reactivity to GM1 Ganglioside in Patients with Guillain-Barre Syndrome [PDF]

, 2005
This study was performed to determine whether increased ganglioside-specific T cell reactivity can be detected in the peripheral blood of patients with Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Alaedini, Alice-Ann Sullivan, Ariga, Asbury, Borsellino, Chiba, Cooper, Cooper, Dyck, Fujioka, Galli, Gong, Heidenreich, Hitoshi, Ho, Hughes, Illes, Judith M. Greer, Kaida, Kaida, Kerryn Green, Kieseier, Kleyweg, Koga, Kracun, Kusunoki, Kusunoki, Kuwabara, McCombe, Michael P. Pender, Odaka, Ogawa-Goto, Pamela A. McCombe, Pan, Pender, Pender, Peter A. Csurhes, Pollard, Prendergast, Press, Raschetti, Rees, Schwerer, Shamshiev, Shamshiev, Susuki, Tagawa, van den Berg, van Doorn, Vincent, Visser, Wicklein, Willison, Winer, Yan, Yu, Yuki, Yuki, Yuki, Yuki   +59 more
core   +1 more source