Results 81 to 90 of about 19,645 (252)

Structural analysis of brain ganglioside acetylation patterns in mice with altered ganglioside biosynthesis [PDF]

, 2013
Gangliosides are sialylated membrane glycosphingolipids especially abundant in mammalian brain tissue. Sialic acid O-acetylation is one of the most common structural modifications of gangliosides which considerably influences their chemical properties ...
Fabris, Dragana, Heffer, Marija, Kalanj Bognar, Svjetlana, Mlinac, Kristina, Rožman, Marko, Vukelić, Željka   +5 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Anti‐GD1b Disorder Presenting as Multiple Mononeuropathies

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Isolated anti GD1b disorders are quite rare. They usually present with ophthalmoplegia, sensory ataxia, paraproteinemia, and elevated cold agglutinants. The response to immunosuppressant treatment does not seem to be very effective. We report a case of isolated mononeuropathies associated with isolated anti‐GD1b antibodies, without ataxia or ...
Kamar Eid, Rim Araoui, Ragheb Ismail, Raja Sawaya   +3 more
wiley   +1 more source

Disease‐modifying effects of ganglioside GM1 in Huntington's disease models

EMBO Molecular Medicine, 2017
Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and psychiatric problems. Previous studies indicated that levels of brain gangliosides are lower than normal in HD models and that administration of ...
Melanie Alpaugh, Danny Galleguillos, Juan Forero, Luis Carlos Morales, Sebastian W Lackey, Preeti Kar, Alba Di Pardo, Andrew Holt, Bradley J Kerr, Kathryn G Todd, Glen B Baker, Karim Fouad, Simonetta Sipione   +12 more
doaj   +1 more source

Brain Alterations Linked to the MPTP Mouse Model of Parkinson's Disease Uncovered by Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
In MPTP‐treated mice, DKI and 1H‐MRS revealed increased hippocampal and thalamic diffusivity with reduced striatal Glu/tCr and Glx/tCr at 24 h. By 72 h, cortical, striatal, and thalamic diffusivity rose, with partial hippocampal recovery. Elevated Tau/tCr and hippocampal metabolite alterations paralleled neuronal loss and gliosis, supporting DKI/1H‐MRS
Ajay Modi, Sheetal Maria, Jana Ruda‐Kucerova, Eva Drazanova, Iveta Harastova‐Pavlova, Alzbeta Sejnoha Minsterova, Kristina Kovacovicova, Daniel Havas, Irena Rektorova, Tiago F. Outeiro, Amit Khairnar   +10 more
wiley   +1 more source

PREDICTOR: A Non‐Enzymatic Catalytic Cascade Tool for in Situ Visualization of Small Extracellular Vesicle Surface glycoRNAs

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
PREDICTOR, a non‐enzymatic catalytic circuit for imaging trace glycoRNAs on sEVs, reveals that glycoRNAs abundance negatively correlates with tumour malignancy and is functionally important for sEVs uptake by macrophages ABSTRACT Glycosylated RNAs (glycoRNAs) are membrane‐displayed RNA‐glycan conjugates, but quantitative in situ analysis of low ...
Shuang Xie, Ben Niu, Ruijia Deng, Liu Feng, Zuowei Xie, Shuang Zhao, Hongzhao Yang, Meilin Gong, Jing Sheng, Ligai Zhang, Yan Pi, Ningtao Cheng, Ming Chen, Kai Chang   +13 more
wiley   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]

, 2017
Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H., Clark, Alex J., Galino, Jorge, Kaller, Malte S., Rinaldi, Simon, Willison, Hugh J.   +5 more
core   +2 more sources

Pyridostigmine Treatment for Pediatric Axonal Guillain–Barré Syndrome

Muscle &Nerve, Volume 73, Issue 4, Page 655-662, April 2026.
ABSTRACT Introduction/Aims Direct involvement of the neuromuscular junction (NMJ) in the inflammatory process of Guillain–Barré syndrome (GBS) has been described. Despite this, the NMJ very rarely serves as a target for direct medical intervention in GBS.
E. Zohar‐Dayan, J. Landa, S. Barak, B. Ben‐Zeev   +3 more
wiley   +1 more source

Effects of cyclodextrins on GM1-gangliosides in fibroblasts from GM1-gangliosidosis patients

Journal of Pharmacy and Pharmacology, 2015
Abstract Objectives GM1-gangliosidosis is an inherited disorder characterized by the accumulation of GM1-gangliosides in many tissues and organs, particularly in the brain. Currently, there is no treatment available for patients with ganglioside storage diseases. Therefore, we investigated the effects
Yuki, Maeda, Keiichi, Motoyama, Taishi, Higashi, Yuka, Horikoshi, Toru, Takeo, Naomi, Nakagata, Yuki, Kurauchi, Hiroshi, Katsuki, Yoichi, Ishitsuka, Yuki, Kondo, Tetsumi, Irie, Hirokazu, Furuya, Takumi, Era, Hidetoshi, Arima   +13 more
openaire   +2 more sources