Advanced Science, 2021 Several signaling processes in the plasma membrane are intensified by ceramides that are formed by sphingomyelinase‐mediated hydrolysis of sphingomyelin.
Hyun‐Ro Lee, Siyoung Q. Choi
doaj +1 more source
From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]
, 2009 Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine +4 more
core +1 more source
Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry
PROTEOMICS, Volume 26, Issue 4, Page 7-22, April 2026.ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu +3 more
wiley +1 more source
Role of Membrane GM1 on Early Neuronal Membrane Actions of Aβ During Onset of Alzheimer\u27s Disease [PDF]
, 2017 The ability of beta-amyloid peptide (Aβ) to disrupt the plasma membrane through formation of pores and membrane breakage has been previously described. However, the molecular determinants for these effects are largely unknown.
Aguayo, Luis G. +3 more
core +1 more source
Immune Response Modulation by Tumor-Secreted Glycosphingolipids [PDF]
, 2014 Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis.
Cely, Ingrid +3 more
core +1 more source
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
Ganglioside-monosialic acid (GM1) for prevention of chemotherapy-induced peripheral neuropathy: a meta-analysis with trial sequential analysis [PDF]
, 2021 Shaoyong Wu +6 more
openalex +1 more source
Protein Science, Volume 35, Issue 4, April 2026.Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova +2 more
wiley +1 more source
"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]
, 2007 Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core +1 more source
Advances in Hydrogel Tissue Engineering for Spinal Cord Injury Repair
Smart Medicine, Volume 5, Issue 2, April 2026.This review systematically introduces the pathological process of spinal cord injury (SCI) and the applications and biological roles of hydrogels in SCI repair. Emerging 4D printing and gene therapy strategies are also discussed. ABSTRACT Spinal cord injury (SCI), which is a severe complication of spinal fractures, often causes the dysfunction of the ...
Ruixing Shui +3 more
wiley +1 more source