Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts [PDF]
, 2019 Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with saturated ...
Antollini, Silvia Susana +1 more
core +1 more source
Impaired levels of gangliosides in the Corpus Callosum of Huntington Disease animal models
Frontiers in Neuroscience, 2016 Huntington Disease (HD) is a genetic neurodegenerative disorder characterized by broad types of cellular and molecular dysfunctions that may affect both neuronal and non-neuronal cell populations. Among all the molecular mechanisms underlying the complex
Alba Di Pardo +2 more
doaj +1 more source
The relationship between depletion of brain GM1 ganglioside and Parkinson's disease. [PDF]
FEBS Open Bio, 2023 Sonnino S.
europepmc +1 more source
Mixed-monolayer glyconanoparticles for the detection of cholera toxin by surface enhanced raman spectroscopy [PDF]
, 2016 The same interactions that a pathogen uses for establishment in a host can be exploited in its detection. The carbohydrates comprising the intestinal cell surface GM1-ganglioside, are targeted by vibrio cholerae via the lectin, cholera toxin, to initiate
Craig, Derek +3 more
core +1 more source
Anti-GM1 ganglioside antibodies in Parkinson's disease.
Acta neurologica Scandinavica, 2000 To determine whether anti-GM1 antibodies are increased in Parkinson's disease (PD).Serum immunoglobulin M (IgM) and IgG anti-GM1 antibodies were detected by enzyme-linked immunosorbent assay (ELISA) in 147 patients with PD and in 186 age-matched normal control subjects.
ZAPPIA, MARIO +12 more
openaire +5 more sources
Effect of serum on ganglioside uptake and choleragen responsiveness of transformed mouse fibroblasts
Journal of Lipid Research, 1978 NCTC 2071 cells, transformed mouse fibroblasts, did not respond to choleragen when grown in chemically defined medium. When grown in medium containing 10% fetal calf serum, however, the cells accumulated cyclic AMP upon exposure to the toxin ...
P H Fishman +3 more
doaj +1 more source
The cytoprotective role of GM1 ganglioside in Huntington disease cells. [PDF]
Mol Biol Rep, 2022 Hart HS +6 more
europepmc +1 more source
Detachment of Membrane Bound Virions by Competitive Ligand Binding Induced Receptor Depletion [PDF]
, 2017 Multivalent receptor-mediated interactions between virions and a lipid membrane can be weakened using competitive nonpathogenic ligand binding. In particular, the subsequent binding of such ligands can induce detachment of bound virions, a phenomenon of ...
Block, Stephan +4 more
core +1 more source
Structural and functional glycosphingolipidomics by glycoblotting with aminooxy-functionalized gold nanoparticle [PDF]
, 2008 Glycosphingolipids (GSLs) synthesized in Golgi apparatus by sequential transfer of sugar residues to a ceramide lipid anchor are ubiquitously distributing on vertebrate plasma membranes.
Midori Abe +2 more
core +1 more source
GM1 ganglioside exerts protective effects against glutamate-excitotoxicity via its oligosaccharide in wild-type and amyotrophic lateral sclerosis motor neurons. [PDF]
FEBS Open Bio, 2023 Lunghi G +13 more
europepmc +1 more source