Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley +1 more source
Cyclic-di-GMP interferes with DNA-MucR-DNA bridging to derepress genes targeted by the xenogeneic silencer MucR. [PDF]
Liu NN +9 more
europepmc +1 more source
Ashwagandha: Is It Safe? Part 1: A Regulatory Review
ABSTRACT Over the last decade, ashwagandha (Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler +5 more
wiley +1 more source
Digital Self-Interference Cancellation Strategies for In-Band Full-Duplex: Methods and Comparisons. [PDF]
Shahghasi A, Montoro G, Gilabert PL.
europepmc +1 more source
ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
RprR is a plant-responsive regulator of exopolysaccharide production, biofilm formation, and virulence in <i>Ralstonia pseudosolanacearum</i>. [PDF]
O'Banion BS +8 more
europepmc +1 more source
Solvent‐Mediated Dewetting Principles for Cell‐Sized Liposome Formation
Dynamics of solvent‐mediated dewetting for giant unilamellar liposome formation. Solvent removal, through changing lipid packing and membrane tension, is shown to induce partial dewetting into equilibrium low and high budding angle morphologies. Complete dewetting requires mechanical force, quantified using optical tweezers.
Mostafa Bakouei +6 more
wiley +1 more source
Study on the antibacterial effect of the new anti-biofilm inhibitor ICAC on <i>Escherichia coli</i>. [PDF]
Bai Y +7 more
europepmc +1 more source
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke +3 more
wiley +1 more source
Compass Rose: Providing Direction and Automation of Glomerular Disease Drug Monitoring. [PDF]
Bobart SA, Aslam N.
europepmc +1 more source

