Results 51 to 60 of about 188,404 (288)

Development of Retraining Systems for the Implementation of the Pharmaceutical Quality System at Pharmaceutical Production Enterprises of the EAEU Countries

Разработка и регистрация лекарственных средств, 2021
Introduction. The publication discusses the state and problems of personnel retraining in the implementation of the pharmaceutical quality system at pharmaceutical enter-prises of the Eurasian Union (EU) countries.Aim.
V. A. Smirnov, V. V. Goryachkin, V. N. Shestakov, R. A. Abramovich   +3 more
doaj   +1 more source

Gravitomagnetism and Relative Observer Clock Effects [PDF]

, 2000
The gravitomagnetic clock effect and the Sagnac effect for circularly rotating orbits in stationary axisymmetric spacetimes are studied from a relative observer point of view, clarifying their relationships and the roles played by special observer ...
Anderson R, Ashtekar A, Bahram Mashhoon, Bazanski S L, Bini D, Bonnor W B, Bonnor W B, Bradley M, Carter B, de Felice F, de Felice F, de Felice F, Donato Bini, Greene R D, Henriksen R H, Iorio L, Iorio L, Iorio L, Iorio L, Jantzen R T, Kramer D, Mashhoon B, Miller J G, Misner C W, Mitskevich N V, Mitskievich N V, Mitskievich N V, Page D, Robert T Jantzen, Semerák O, Semerák O, Stedman G E, Stedman G E, Tartaglia A, Tartaglia A, Wolf P, Znajek R L   +36 more
core   +2 more sources

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

PROBLEMS OF CONFORMITY OF THE RECORDS INTEGRITY WITH THE REQUIREMENTS OF GOOD MANUFACTURING PRACTICE. REPORT 1. ACTUALITY OF THE RECORDS INTEGRITY CONSERVATION

Разработка и регистрация лекарственных средств, 2019
Integrity of records or data integrity is the most «hot» requirement when assessing documentation systems for compliance with Good Manufacturing Practice (GMP). It's in the center of focus of attention during inspections of pharmaceutical companies. This
I. A. Osmolovskaya, O. V. Zarochinskaya, M. O. Emelianov, D. V. Somov   +3 more
doaj  

Analisis HACCP Pada UKM Minuman Siap Saji Aloe Vera (ALOJA) Sebagai Sarana Memenuhi Standar Produksi Pangan Yang Baik

Amerta Nutrition, 2020
Background: BPOM stated that in 2017, small and micro food enterprises were responsible for 49,5 % food borne disease in Indonesia. Indonesian government had provided guidance about good handling standard for food product (GMP) by UU No.18 Tahun 2012 ...
Dimas Bayu Pinandoyo, Asriadi Masnar
doaj   +1 more source

Precise determination of low-Q nucleon electromagnetic form factors and their impact on parity-violating e-p elastic scattering [PDF]

, 2006
The extraction of the strangeness form factors from parity violating elastic electron-proton scattering is sensitive to the electromagnetic form factors at low Q^2.
Arrington, John, Sick, Ingo
core   +2 more sources

High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation

Advanced Functional Materials, EarlyView.
Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird, Connor Smith, Nahal Habibi, Samantha Rivera, Saeed Mortezazadeh, Reece Martin, Benjamin M. Geilich, Gilles Besin, Borries Demeler   +8 more
wiley   +1 more source

Overview of the validation procedures for a vaccine production: from R;D level to the pre-qualification stage

Vaccine Research, 2015
Just like any other process, vaccine manufacturing procedures are defined as a series of interrelated functions and activities using a variety of specified actions and equipment designed to produce a defined product.
H Kaghazian, D Doroud
doaj  

Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype

Frontiers in Immunology, 2019
The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells.
David Eisel, David Eisel, David Eisel, Krishna Das, Krishna Das, Krishna Das, Elke Dickes, Rainer König, Wolfram Osen, Stefan B. Eichmüller   +9 more
doaj   +1 more source

Evaluation of Good Manufacturing Practices (GMP) and Sanitation Standard Operating Procedure (SSOP) Implementation for Supporting Sustainable Production in Bakery SMEs

Turkish Journal of Agriculture: Food Science and Technology, 2020
Resources efficiency in production is essential to support sustainable production. “X” Bakery is one of the bread small and medium enterprises (SMEs) in Batu, East Java Indonesia.
Sucipto Sucipto, Petri Wani Sumbayak, Claudia Gadizza Perdani   +2 more
doaj   +1 more source