Results 81 to 90 of about 3,060 (210)

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Differential Gene Expression in Gonadotropin-Releasing Hormone Neurons of Male and Metestrous Female Mice. [PDF]

, 2015
BACKGROUND: Gonadotropin-releasing hormone (GnRH) neurons play a pivotal role in regulation of the hypothalamic-pituitary gonadal axis in a sex-specific manner.
Auer, H., Farkas, Imre, Liposits, Zsolt, Rodolosse, A., Solymosi, Norbert, Sárvári, Miklós, Vastagh, Csaba   +6 more
core   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies

Scientific Reports
Dysfunction of central serotonergic neurons is known to cause depressive disorders in humans, who often show reproductive and/or glucose metabolism disorders.
Sho Nakamura, Takuya Sasaki, Yoshihisa Uenoyama, Naoko Inoue, Marina Nakanishi, Koki Yamada, Ai Morishima, Reika Suzumura, Yuri Kitagawa, Yasuhiro Morita, Satoshi Ohkura, Hiroko Tsukamura   +11 more
doaj   +1 more source

Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice [PDF]

, 2018
Restraint stress is a psychosocial stressor that suppresses reproductive status, including LH pulsatile secretion, but the neuroendocrine mechanisms underlying this inhibition remains unclear.
Hughes, Jessica K, Kauffman, Alexander S, Parra, Ruby A, Volk, Katrina M, Yang, Jennifer A   +4 more
core   +1 more source

Neuroanatomy of the human hypothalamic kisspeptin system. [PDF]

, 2014
Hypothalamic kisspeptin (KP) neurons are key players in the neuronal network that regulates the onset of puberty and the pulsatile secretion of gonadotropin-releasing hormone (GnRH).
Hrabovszky, Erik
core   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Rodent Models of Polycystic Ovary Syndrome [PDF]

, 2013
Rodents are clearly valuable models for assessing disruption of fertility. The effects of different steroid treatments at different stages of reproductive life through from fetal to adult have been assessed for effects on fertility, ovarian morphology ...
Duncan, Colin, McNeilly, Alan S
core   +1 more source

Derangement of the hypothalamic GnRH pulse generator in women with epilepsy

Seizure, 1993
An increased frequency of reproductive endocrine diseases has been described in women with epilepsy and a subclinical reproductive dysfunction has been suggested in normally menstruating epileptic women. We assessed the reproductive endocrine function in 11 normally menstruating, drug-free epileptic women, evaluating the basal hormonal profile and LH ...
R. Meo, BILO, LEONILDA, NAPPI, CARMINE, A. P. Tommaselli, R. Valentino, C. Nocerino, STRIANO, SALVATORE, G. A. Buscaino   +7 more
openaire   +4 more sources

Waning light, waxing pain: The lunar cycle's association with migraine headache occurrence

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary While migraine headaches can be hard to predict, some patients believe headaches are connected to the moon‘s phases. Our research showed that migraine attacks were 34% more likely to occur during the new moon than during the full moon.
Alexander Yoo, Brendan Keenan, Angeliki Vgontzas, Murray A. Mittleman, Suzanne M. Bertisch, Ron Anafi   +5 more
wiley   +1 more source