Results 121 to 130 of about 29,288 (219)

METTL3 Alleviates Liver Abscess by Enhancing Macrophage Efferocytosis via m6A Methylation of Nrf2 mRNA

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Persistent inflammation and impaired macrophage efferocytosis contribute to liver injury during bacterial liver abscesses (BLA). This study was conducted to investigate whether METTL3 alleviates BLA by promoting macrophage efferocytosis through m6A methylation of Nrf2 mRNA. Materials and Methods METTL3 was overexpressed in the liver
Genwang Wang, Ding Luo, Yu Pang, Chanjuan Gao, Dong Jin, Qi Wang   +5 more
wiley   +1 more source

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2‐Related Centronuclear Myopathy Mouse Model

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Autosomal dominant centronuclear myopathy (ADCNM), most commonly caused by mutations in the dynamin 2 (DNM2) gene, is a rare congenital myopathy characterized by progressive muscle weakness and atrophy. Myostatin, a key negative regulator of skeletal muscle mass, has shown therapeutic potential in several models of neuromuscular ...
Durieux Anne‐Cécile, Arnould David, Velarde Mathias, Allibert Valentine, Paret Chloé, Debelley Quentin, Kizilkilic Esra, Chambon Sidney, Girard Emmanuelle, Collin Louise, Gensel Alexandre, Castells Josiane, Pasternack Aja, Bowen Maximilien, Morel Baptiste, Hourdé Christophe, Laurent Schaeffer, Ritvos Olli, Bitoun Marc, Mounier Rémi, Freyssenet Damien   +20 more
wiley   +1 more source

Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
A whole‐body map of sEVs from a single pig, including 133 samples spanning 10 systems, revealed striking tissue‐specific heterogeneity in yield. Importantly, a conserved core cargo set comprising candidate sEV markers (ACTG1, CFL1, and ANXA2), RNA‐binding proteins, the let‐7 miRNA family, and ferritin genes was defined from 105,409 (88.6% full‐length ...
Naixiang Yu, Jinxiu Liu, Chenliang Lai, Siyi Liu, Jiacheng Wei, Jiahong Zhong, Sanya Xiong, Qingjie Zeng, Junwu Ma, Zhou Zhang, Zhiyan Zhang   +10 more
wiley   +1 more source

Genetic and Pharmacological Targeting of Hsp72 Overexpression/Induction in an Alzheimer's Disease Mouse Model With Combined Amyloid and Tau Pathology

Journal of Neuroscience Research, Volume 104, Issue 10, October 2026.
We investigated targeting Hsp72 protein expression genetically and via a drug, in a model of combined amyloid and tau pathology. Neither approach reduced amyloid or tau or improved body composition or movement ability. Both treatments tended to slightly improve survival in male mice and anxiety‐like behavior in female mice.
J. P. S. Marshall, A. Harutyunyan, J. Ng, O. M. West, J. M. Collins, A. E. King, J. Morizzi, P. Wright, A. C. Calkin, B. G. Drew, N. C. Jones, P. A. Adlard, M. A. Febbraio, D. C. Henstridge   +13 more
wiley   +1 more source

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Quinoa and Peanut Extracts as Alternatives to Animal‐Derived Extracellular Matrix Proteins in Cultured Meat Production

Journal of Food Science, Volume 91, Issue 10, October 2026.
ABSTRACT Cultured meat, produced through the cultivation of animal cells, represents a sustainable and ethical alternative to traditional livestock farming. The cultivation and expansion of animal cells for cultured meat production rely heavily on extracellular matrix (ECM) proteins, which are needed for cell adhesion, proliferation, and ...
Dominik Mundt, Kuo‐Hui Chiu, Stefan Schillberg, Che Julius Ngwa   +3 more
wiley   +1 more source

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies

Aging Cell, Volume 25, Issue 10, October 2026.
AMP‐activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direct pharmacological activation of AMPK with the compound 991 in vivo extends lifespan in multiple model organisms: the fission yeast Schizosaccharomyces ...
Eliano dos Santos, Marie Blickling, Fiona C. Leiper, John‐Patrick Alao, Claudia Lennicke, Andrea Foley, Jon R. Wilson, Steven J. Gamblin, Bénédicte Chazaud, Giovanna Lollo, Rémi Mounier, Gaëtan Juban, Charalampos Rallis, David Carling, Filipe Cabreiro, Helena M. Cochemé   +15 more
wiley   +1 more source

Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro‐Inflammatory Responses and IgE Production

Allergy, Volume 81, Issue 10, Page 3641-3658, October 2026.
Soy lecithin and DATEM, the two commonly used food emulsifiers introduced into many foods including peanut butter and puffed bread, in the 2000s, impair intestinal epithelial barrier integrity in human gut‐on‐a‐chip and induced pluripotent stem cell colon organoid models.
Duygu Yazici, Yuka Hayashi, Yagiz Pat, Jennifer Hotie, Mehmet Ali Balci, Sena Ardicli, Juan Felipe Lopez, Ozge Ardicli, Bingjie Zhao, Angel Maldonado, Can Zeyneloglu, Kenji Matsumoto, Manru Li, Beate Rückhert, Lihong Chang, Ismail Ogulur, Vahap Eldem, Raja Dhir, Mubeccel Akdis, Kari Nadeau, Oscar Palomares, Hideaki Morita, Cezmi A. Akdis   +22 more
wiley   +1 more source

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

The Effects of Extracellular Vesicles From Cancer Cells in Acidosis or ER Stress to Endothelial Cells: Angiogenesis and Endothelial Activation

Biology of the Cell, Volume 118, Issue 10, October 2026.
When breast cancer cells experience ER stress, their large extracellular vesicles promote increased endothelial migration and endothelial permeability. When these cancer cells are adapted to acidosis, their extracellular vesicles increase permeability and migration, reduce angiogenesis and tumor cell adhesion to endothelia, and activate ER stress ...
Ana Sayuri Yamagata, Ramon H. G. Teles, Nicolas J. Villarinho, Ana Carolina Lima Ralph, Nicolly C. dos Santos, Kevin Perera, Gisela R. Terçarioli, Amanda Ikegami, Anayara Ristow, Daniel Pecoraro Demarque, Jeremy Newton, Luiz E. da Silva, Edmond W. K. Young, Ruy G. Jaeger, Vanessa Morais Freitas   +14 more
wiley   +1 more source