Results 171 to 180 of about 228,960 (304)

Multilayered interplay between the cGAS-STING pathway and autophagy. [PDF]

Autophagy Rep
Huang Z, Gao X, Lin J, Feng D, Lu G.
europepmc   +1 more source

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source

Reversible control of post-Golgi transport by brefeldin A reveals recycling endosome maturation during glycosylphosphatidylinositol-anchored protein transport. [PDF]

Nat Commun
Takiguchi A, Shek HT, Sasaki S, Tago T, Uehara T, Goto Y, Toyooka K, Kurokawa K, Tojima T, Nakano A, Maeda M, Satoh T, Satoh AK.   +12 more
europepmc   +1 more source

Unmasking Glycoforms: Lectin‐Based Profiling and Functional Implications of Targeted Glycosylation Knockouts in Chinese Hamster Ovary Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Monoclonal antibody (mAb) glycosylation is a critical quality attribute that is difficult to rationally engineer and rapidly assess during cell line development. Here, we investigate whether cell‐surface glycosylation can serve as a surrogate readout of mAb product glycosylation following targeted glycogene engineering in CHO cells.
Cristina Abascal Ruiz, Sheryl Li Yan Lim, Jacobus Brink, Sara Carillo, Eoin Casey, Jonathan Bones, Ioscani Jiménez del Val   +6 more
wiley   +1 more source

Golgi organization regulates stem cell function in the small intestine. [PDF]

Nat Commun
Belevich I, Porcile L, Sola-Carvajal A, Grommisch D, Annusvar K, Heinz P, Das S, Webb AT, Andersson S, Pentinmikko N, Villablanca EJ, Goldenring JR, Kasper M, Jokitalo E, Coffey RJ, Katajisto P, Scharaw S.   +16 more
europepmc   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Uncleaved signal peptide drives Golgi-bypassing secretion of the baculovirus fusion protein GP64. [PDF]

Microbiol Spectr
Zhu D, Hao Y, Zhang J, Xu Y, Hao B, Huang J.   +5 more
europepmc   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Reversible Holmes Tremor due to Middle Cerebral Artery Giant Aneurysm

Tremor and Other Hyperkinetic Movements, 2019
Tino Emanuele Poloni, Alberto Galli, Arenn Faye Carlos, Emanuela Riva, Valentina Medici, Annalisa Davin, Antonio Guaita, Mauro Ceroni   +7 more
doaj   +1 more source

Organelle network dysfunction in primary cardiomyopathy: An integrated perspective on pathogenesis and therapeutics. [PDF]

J Mol Cell Cardiol Plus
Pu S, Yang P.
europepmc   +1 more source