Results 191 to 200 of about 228,960 (304)

Modeling Cohen Syndrome in Phoenix Cells: VPS13B Loss Causes Organelle Stress, G1/S Delay, and Fibrillary Inclusion Bodies Formation. [PDF]

Cells
Morozova KN, Wolf ER, Kiseleva EV, Smirnov AV, Pershina EG, Pristyazhnyuk IE.   +5 more
europepmc   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Zinc-mediated structural and functional regulation of ERp44 and ERGIC-53 in protein quality control. [PDF]

J Biochem
Watanabe S, Inaba K.
europepmc   +1 more source

trans-Golgi retention of a plasma membrane protein : mutations in the cytoplasmic domain of the asialoglycoprotein receptor subunit h1 result in trans-Golgi retention [PDF]

, 1995
J M Wahlberg, M Spiess, F Reymond, Wahlberg, J. M., Simmen, T., Spiess, M., I Geffen, Reymond, F., T Simmen, Geffen, I.   +9 more
core   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability. [PDF]

Signal Transduct Target Ther
Lee Y, Ham O, Lee H, Kim DS, Lim JH, Jung CR, Huh JW, Son MY, Lee MO.   +8 more
europepmc   +1 more source

Neonatal Exposure to Antibiotics Triggers Obesity in Adulthood by Permanent Microbiota Dysbiosis and Reduction of Adipose Regulatory T Cells

Barrier Immunity, EarlyView.
ABSTRACT Neonatal dysbiosis of the gut microbiota represents a critical environmental factor promoting obesity, but the underlying immunological mechanisms remain unknown. We show here that neonatal treatment of mice with broad‐spectrum antibiotics for the first 3 weeks of life (NeoATB) resulted in the development of obesity and metabolic abnormalities
Peter Zanvit, Junji Xu, Wenjing Yang, Nancy Guo, Tianming Yu, Xue Jiao, Michaela Prochazkova, Wenwen Jin, Na Liu, Sang‐A Park, Cheryl Chia, Daxesh P. Patel, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Frank J. Gonzalez, Yasmine Belkaid, Yingzi Cong, WanJun Chen   +18 more
wiley   +1 more source

Airway secretory cells contain both a perinuclear Golgi ribbon and dispersed Golgi satellites. [PDF]

Am J Respir Cell Mol Biol
Hoang ON, Chan CE, Brenner JM, Leza-Rincon D, Jaramillo AM, Dolan B, Aziz AW, Cardenas RA, Cardenas GJ, Galvez ED, Hales JB, Nunez-Pena ES, Yang B, Powell RT, Vergara L, Karmouty-Quintana H, Magnusson JM, Hansson GC, Adachi R, Dickinson JD, Evans CM, Courson JA, Burns AR, Tuvim MJ, Dickey BF.   +24 more
europepmc   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Structure-Activity Relationship of Cycling Molecular Assemblies for Golgi Targeting and Disruption. [PDF]

J Med Chem
Tan W, Zhang Q, Hong P, Xu B.
europepmc   +1 more source