Results 201 to 210 of about 344,692 (261)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

ELAPOR1 regulates VPS54-mediated GARP complex formation and proacrosomal vesicle fusion during spermatogenesis. [PDF]

Theranostics
Ding C, Liang T, Yang M, Wang L, Yin X, Li G, Wang Z, Guo J, Zhang L, Yang J, Xia X, Xu Y, Liu J, Jiang H.   +13 more
europepmc   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Editorial: Reviews in ARF, the most misunderstood G protein I ever knew: a collection of papers exploring the multifaceted functions of an ancient protein family. [PDF]

Front Mol Biosci
Randazzo PA, Santy L, Chen PW.
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early <i>Legionella</i> infection. [PDF]

Proc Natl Acad Sci U S A
Im HN, Lee Y, Song Y, Hahn H, Jeon H, Shin D, Lee S, Kim KH, Kim KT, Suh SW, Jang DM, Kim HS.   +11 more
europepmc   +1 more source

Media‐dependent performance of rabies virus‐like particle production under low oxygen tension in baculovirus‐infected Sf9 cells

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Rabies continues to pose a major public health threat, causing approximately 59 000 deaths each year, especially in regions with limited resources where high costs restrict vaccine access. Safer and scalable vaccine platforms, such as virus‐like particles, are promising alternatives, but their production is highly sensitive to ...
Júlia Públio Rabello, Milena Miyu Teruya, Fernanda Angela Correia Barrence, Thaissa Consoni Bernardino, Jaci Leme, Luis Giovani de Oliveira Guardalini, Noemi Nosomi Taniwaki, Soraia Attie Calil Jorge, Eutimio Gustavo Fernández Núñez   +8 more
wiley   +1 more source

Antiviral Activity of Microbial Metabolites Monensin and Brefeldin A Against Toscana Virus: In Vitro Evaluation and Mechanistic Insights. [PDF]

Viruses
Di Clemente L, Zannella C, Palma F, Acunzo M, Giugliano R, Chianese A, Bonura F, De Grazia S, Giammanco GM, De Filippis A, Galdiero M.   +10 more
europepmc   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

Construction and validation of golgi apparatus-related genes as predictors of the immune microenvironment and prognosis in colorectal cancer. [PDF]

Transl Oncol
Chen J, Wang F.
europepmc   +1 more source