Results 41 to 50 of about 214,335 (315)

Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion

, 2002
Characterization of mammalian NSF (G274E) and Drosophila NSF (comatose) mutants revealed an evolutionarily conserved NSF activity distinct from ATPase-dependent SNARE disassembly that was essential for Golgi membrane fusion.
Yuval Sagiv, Zvulun Elazar, Katrin Deinhardt, Richard Newman, Graham Warren, Shima, David T., Müller, Joyce M.M., Warren, Graham, David T. Shima, James Shorter, Sagiv, Yuval, Joyce M.M. Müller, Shorter, James, Newman, Richard, Elazar, Zvulun, Deinhardt, Katrin   +15 more
core   +1 more source

Both Post‐Golgi and Intra‐Golgi Cycling Affect the Distribution of the Golgi Phosphoprotein GPP130 [PDF]

Traffic, 2007
Golgi phosphoprotein, GPP130, a cis Golgi protein, is representative of proteins cycling between the Golgi apparatus and endosomes in a pH‐sensitive manner. The present qualitative data are insufficient to distinguish the relative contributions of Golgi and endosomal processes in regulating the cycling of such proteins.
Tregei, Starr, Kimberly, Forsten-Williams, Brian, Storrie   +2 more
openaire   +2 more sources

The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans [PDF]

, 2013
Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway.
Anne Spang, Ackema, K. B., Jachen A Solinger, Karin B Ackema, Ursula Sauder, Solinger, J. A., Karin B. Ackema, Jachen A. Solinger (254344), Jachen A. Solinger, Karin B. Ackema (423507), Ursula Sauder (250540), Spang, A., Anne Spang (205738), Sauder, U.   +13 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Acid sphingomyelinase regulates the localization and trafficking of palmitoylated proteins

Biology Open, 2019
In human, loss of acid sphingomyelinase (ASM/SMPD1) causes Niemann–Pick disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. Our mass spectrometry-based proteomic analyses have identified >
Xiahui Xiong, Chia-Fang Lee, Wenjing Li, Jiekai Yu, Linyu Zhu, Yongsoon Kim, Hui Zhang, Hong Sun   +7 more
doaj   +1 more source

Acetone and Toluene Gas Sensing by WO₃: Focusing on the Selectivity from First Principle Calculations

Nanomaterials, 2022
Sensitivity and selectivity are the two major parameters that should be optimized in chemiresistive devices with boosted performances towards Volatile Organic Compounds (VOCs).
Mario Italo Trioni, Fausto Cargnoni, Stefano Americo, Eleonora Pargoletti, Gian Luca Chiarello, Giuseppe Cappelletti   +5 more
doaj   +1 more source

Tomato spotted wilt virus glycoproteins induce the formation of endoplasmic reticulum- and Golgi-derived pleomorphic membrane structures in plant cells

, 2008
Tomato spotted wilt virus (TSWV) particles are spherical and enveloped, an uncommon feature among plant infecting viruses. Previous studies have shown that virus particle formation involves the enwrapment of ribonucleoproteins with viral glycoprotein ...
Kormelink, R.J.M., Foresti, O., Denecke, J., Wellink, J., Goldbach, R.W., Ribeiro, D.M.O.G.   +5 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration

eLife, 2014
ER O-glycosylation can be induced through relocalisation GalNAc-Transferases from the Golgi. This process markedly stimulates cell migration and is constitutively activated in more than 60% of breast carcinomas.
Joanne Chia, Keit Min Tham, David James Gill, Emilie Anne Bard-Chapeau, Frederic A Bard   +4 more
doaj   +1 more source

Electrochemical Organic Synthesis of Electron-Rich Biaryl Scaffolds: An Update

Molecules, 2021
Biaryl scaffolds are widely spread in biologically important natural products, in numerous therapeutic agents, but they are also considered a privileged class of ligands and (organo)catalysts; therefore, the development of efficient alternative ...
Fabrizio Medici, Simonetta Resta, Alessandra Puglisi, Sergio Rossi, Laura Raimondi, Maurizio Benaglia   +5 more
doaj   +1 more source