Functional selectivity of GPCR-directed drug action through location bias. [PDF]
, 2017 G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco +6 more
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An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]
, 2003 The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B. +7 more
core +1 more source
Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP [PDF]
, 2005 Plasmodium falciparum, the causative agent of malaria, relies on a sophisticated protein secretion system for host cell invasion and transformation.
Cowman, Alan F. +6 more
core +1 more source
Diverse roles for the p24 family of proteins in eukaryotic cells
Biomolecular Concepts, 2012 Members of the p24 protein family form a highly conserved family of type I transmembrane proteins that are abundant components of the early secretory pathway.
Schuiki Irmgard, Volchuk Allen
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Polytopic cargo proteins are synthesized and exported along the secretory pathway from the endoplasmic reticulum (ER), through the Golgi apparatus, with eventual insertion into the plasma membrane (PM).
Timothy Angelotti
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Frontiers in Molecular Neuroscience, 2019 The calmodulin (CaM)-like Ca2+-sensor proteins caldendrin, calneuron-1 and -2 are members of the neuronal calcium-binding protein (nCaBP)-family, a family that evolved relatively late during vertebrate evolution.
Jennifer Mundhenk +3 more
doaj +1 more source
Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning. [PDF]
, 2017 The intracellular bacterium Chlamydia trachomatis develops in a parasitic compartment called the inclusion. Posttranslationally modified microtubules encase the inclusion, controlling the positioning of Golgi complex fragments around the inclusion.
Agata Nawrotek +10 more
core +3 more sources
Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases
Frontiers in Cell and Developmental Biology, 2020 Autophagy has dual effects in human diseases: appropriate autophagy may protect cells from stress, while excessive autophagy may cause cell death. Additionally, close interactions exist between autophagy and the Golgi.
Shuwen Deng, Jia Liu, Xiaomei Wu, Wei Lu
doaj +1 more source
Tomato spotted wilt virus glycoproteins induce the formation of endoplasmic reticulum- and Golgi-derived pleomorphic membrane structures in plant cells [PDF]
, 2008 Tomato spotted wilt virus (TSWV) particles are spherical and enveloped, an uncommon feature among plant infecting viruses. Previous studies have shown that virus particle formation involves the enwrapment of ribonucleoproteins with viral glycoprotein ...
Denecke, J. +5 more
core +2 more sources
Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system
eLife, 2018 The yeast Dsc E3 ligase complex has long been recognized as a Golgi-specific protein ubquitination system. It shares a striking sequence similarity to the Hrd1 complex that plays critical roles in the ER-associated degradation pathway.
Xi Yang +3 more
doaj +1 more source