Acid sphingomyelinase regulates the localization and trafficking of palmitoylated proteins [PDF]
Biology Open, 2019 In human, loss of acid sphingomyelinase (ASM/SMPD1) causes Niemann–Pick disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. Our mass spectrometry-based proteomic analyses have identified >
Xiahui Xiong +7 more
doaj +3 more sources
Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]
, 2012 Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Jarmoszewicz, Katarzyna +3 more
core +15 more sources
Cell Stress, 2021 Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity ...
Constantinos Demetriades +2 more
doaj +1 more source
Src activates retrograde membrane traffic through phosphorylation of GBF1
eLife, 2021 The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown.
Joanne Chia +8 more
doaj +1 more source
Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster [PDF]
Open Biology, 2017 Cytokinesis requires a tight coordination between actomyosin ring constriction and new membrane addition along the ingressing cleavage furrow. However, the molecular mechanisms underlying vesicle trafficking to the equatorial site and how this process is
Stefano Sechi +8 more
doaj +1 more source
Cdc42 regulates cytokine expression and trafficking in bronchial epithelial cells
Frontiers in Immunology, 2022 Airway epithelial cells can respond to incoming pathogens, allergens and stimulants through the secretion of cytokines and chemokines. These pro-inflammatory mediators activate inflammatory signaling cascades that allow a robust immune response to be ...
Rowayna Shouib, Gary Eitzen
doaj +1 more source
Alzheimer’s Research & Therapy, 2020 Background Preventing dementia onset is one of the global public health priorities: around 35% of dementia cases could be attributable to modifiable risk factors.
Elena Rolandi +6 more
doaj +1 more source
Up-regulation of Osh6 boosts an anti-aging membrane trafficking pathway toward vacuoles
Microbial Cell, 2022 Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners.
Ilham Kadhim +4 more
doaj +1 more source
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]
, 2020 Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Arias-Muñoz, Eloisa +16 more
core +2 more sources
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
core +2 more sources