Results 71 to 80 of about 228,960 (304)

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting

Scientific Reports
Making early and informative diagnoses of mild cognitive impairment (MCI) is highly important for planning timely and appropriate interventions aimed at dementia risk reduction.
Simone Galati, Michele Rossi, Federica Del Signore, Giulia Locatelli, Antonio Guaita, Elena Rolandi   +5 more
doaj   +1 more source

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function [PDF]

, 2011
Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles, Tebar Ramon, Francesc, Reverter Martín, Meritxell, Rentero Alfonso, Carles, Meritxell Reverter, Mulay, Vishwaroop, Peta Wood, Vilà de Muga, Sandra, Álvarez-Guaita, Anna, Anna Alvarez-Guaita, Albert Pol, Francesc Tebar, Carlos Enrich, Cairns, Rose, Joan Blasi, Blasi Cabús, Joan, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood, Peta, Katia Monastyrskaya, Grewal, Thomas, Pol i Sorolla, Albert, Thomas Grewal, Monastyrskaya, Katia, Sandra Vilà de Muga   +25 more
core   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Arfs on the Golgi: four conductors, one orchestra

Frontiers in Molecular Biosciences
Arfs are small Ras-superfamily proteins important for regulating membrane trafficking including the recruitment of vesicular coats as well as a diverse range of other functions.
Selma Yilmaz Dejgaard, Selma Yilmaz Dejgaard, John F. Presley   +2 more
doaj   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

The Golgin GMAP-210 [PDF]

, 2008
The protein GMAP-210 (Golgi Microtubule Associated Protein of 210 kDa) is a long coiled-coil protein, which localises to the Golgi apparatus. It is part of the loosely defined protein group of the golgins, which are involved in establishing the Golgi ...
Egerer, Johannes
core   +1 more source

Selective synthesis of thioethers in the presence of a transition-metal-free solid Lewis acid

Beilstein Journal of Organic Chemistry, 2016
The synthesis of thioethers starting from alcohols and thiols in the presence of amorphous solid acid catalysts is reported. A silica alumina catalyst with a very low content in alumina gave excellent results in terms of both activity and selectivity ...
Federica Santoro, Matteo Mariani, Federica Zaccheria, Rinaldo Psaro, Nicoletta Ravasio   +4 more
doaj   +1 more source

The role of the lectin VIP36 in the early secretory pathway [PDF]

, 2010
Lectins are of emerging importance for quality control and intracellular transport of glycoproteins in mammalian cells. One of the most prominent lectins involved in intracellular transport is ERGIC-53, which belongs to the family of L-type lectins ...
Reiterer, Veronika
core   +1 more source