Results 41 to 50 of about 334,002 (313)

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

The role of mitogen-activated protein kinase–extracellular receptor kinase pathway in female fertility outcomes: a focus on pituitary gonadotropins regulation

Therapeutic Advances in Endocrinology and Metabolism, 2018
Mammalian reproduction systems are largely regulated by the secretion of two gonadotropins, that is, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Samira Kahnamouyi, Mohammad Nouri, Laya Farzadi, Masoud Darabi, Vahid Hosseini, Amir Mehdizadeh   +5 more
doaj   +1 more source

Menstruation in an infant: a case report of exacerbated mini-puberty

Portuguese Journal of Pediatrics, 2023
There are three periods throughout life in which an activation of the hypothalamus-pituitary-gonads axis takes place: prenatal, immediate postnatal period and puberty. The period that occurs after the first week of life and in which there are high levels
Carolina Amaro-Gonçalves, Ana Dias-Curado, Sofia G. Ferreira, Brígida Robalo, Lurdes Sampaio   +4 more
doaj   +1 more source

Fertility preservation in gynaecologic cancers [PDF]

, 2018
Due to substantial improvement in the diagnosis and treatment of gynaecologic cancers, a better understanding of patient care needs to be revised. We reviewed the literature related to fertility preservation strategies in gynaecological cancer and ...
De Felice, Francesca, Di Pinto, Anna, Marchetti, Claudia, Musella, Angela, Muzii, Ludovico, Palaia, Innocenza, Panici, Pierluigi Benedetti, Porpora, Maria Grazia, Tomao, Federica, Tombolini, Vincenzo   +9 more
core   +1 more source

Mapping quantitative trait loci underlying body weight changes that act at different times during high‐fat diet challenge in collaborative cross mice

Animal Models and Experimental Medicine, EarlyView.
Over one billion people worldwide suffer from obesity, and the number is continually rising. Animal models, especially mouse models, are crucial to identifying the genetic components of complex disorders and exploring the potential applications of these genetic findings.
Hanifa J. Abu‐Toamih Atamni, Iqbal M. Lone, Ilona Binenbaum, Kareem Midlej, Eleftherios Pilalis, Richard Mott, Aristotelis Chatziioannou, Fuad A. Iraqi   +7 more
wiley   +1 more source

Neuroendocrine regulation of gonadotropin secretion in seasonally breeding birds

Frontiers in Neuroscience, 2013
Seasonally breeding birds detect environmental signals, such as light, temperature, food availability and presence of mates to time reproduction. Hypothalamic neurons integrate external and internal signals, and regulate reproduction by releasing ...
Takayoshi eUbuka, George E Bentley, Kazuyoshi eTsutsui   +2 more
doaj   +1 more source

Impact of an increased exposure with manganese and nickel on pituitary hormones in women with ovarian polycystosis

Репродуктивная эндокринология, 2020
Objective of the study: to evaluate the possible impact of manganese and nickel on the state of gonadotropic pituitary function and prolactin secretion. Materials and methods. For the study 2 groups of women were selected. The control group consisted of
М. Г. Проданчук, Т. Ф. Татарчук, С. В. Гуньков, П. Г. Жмінько, С. І. Регеда   +4 more
doaj   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

FSH and LH Secretion from in-vitro Cultured Buffalo Anterior Pituitary Cells Following Treatment with Diethyl-Stilbestrol and Medroxy-Progesterone and Their Effects on Ovarian Activity and Hematological Variables of Female Rabbits [PDF]

Pakistan Veterinary Journal, 2016
Aims of this study were: to investigate whether FSH and LH secretion from in-vitro cultured buffalo adenohypophyseal cells can be increased by supplementing culture media with diethyl-stilbestrol and medroxy-progesterone, respectively; to monitor ...
Kaleem Iqbal1, Nafees Akhtar1*, Nazir Ahmad1 and Sajjad-ur-Rahman2
doaj