PLoS ONE, 2020 The tolerance of ruminants to gossypol, a natural phenolic compound derived from the cotton plant, is greater than that of monogastric animals, partially because of the gossypol-degrading bacteria in the rumen of the ruminants. In this study, we aimed to
CaiDie Wang +4 more
doaj +3 more sources
Screening of a Gossypol-Removing Yeast Strain and Characterization of Its Removal Mechanism [PDF]
MicroorganismsGossypol, a polyphenolic naphthalene derivative and yellow polyphenolic pigment found in cotton seed glands, presents notable environmental, animal, and human health hazards.
Yushuo Zhang +5 more
doaj +2 more sources
CRISPR/Cas9-mediated mutation of GhCAD decreases the gossypol content of cottonseed [PDF]
Journal of Biological EngineeringCottonseed is the most important byproduct of cotton production. However, high free gossypol contents limit the application of cottonseed in the food or feed industry.
Lili Zhou +8 more
doaj +2 more sources
Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore
BMC Genomics, 2011 Background Hormesis is a biphasic biological response characterized by the stimulatory effect at relatively low amounts of chemical compounds which are otherwise detrimental at higher concentrations.
de la Paz Celorio-Mancera Maria +3 more
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Molecular Target Identification of Gossypol Against Cervical Cancer Based on Target Fishing Technology [PDF]
PharmaceuticsObjectives: This study aims to investigate the impact of Gossypol on human cervical cancer cells and elucidate its mechanism of action to establish a foundation for further clinical investigations.
Jinyan Li +6 more
doaj +2 more sources
Gossypol Toxicity from Cottonseed Products
Scientific World Journal, The, 2014 Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves, seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by-product of cotton that is used for animal feeding because it is rich in oil and proteins.
Benito Soto-Blanco
exaly +2 more sources
Metabolomic Profiling and Network Toxicology: Mechanistic Insights into Effect of Gossypol Acetate Isomers in Uterine Fibroids and Liver Injury [PDF]
PharmaceuticalsObjective: Gossypol is a natural polyphenolic dialdehyde product that is primarily isolated from cottonseed. It is a racemized mixture of (−)-gossypol and (+)-gossypol that has anti-infection, antimalarial, antiviral, antifertility, antitumor and ...
Zishuo Liu, Hui Zhang, Jun Yao
doaj +2 more sources
A Spin-Labeled Derivative of Gossypol [PDF]
MoleculesGossypol and its derivatives arouse interest due to their broad spectrum of biological activities. Despite its wide potential application, there is no reported example of gossypol derivatives bearing stable radical functional groups.
Andrey V. Stepanov +8 more
doaj +2 more sources
Heterologous Overexpression of Cytochrome P450BM3 from <i>Bacillus megaterium</i> and Its Role in Gossypol Reduction. [PDF]
Toxins (Basel)Fan W +6 more
europepmc +3 more sources