Results 21 to 30 of about 14,116 (259)
Archives of Andrology, 1982 The discovery by the Chinese scientists of gossypol as a male fertility regulating agent constitutes a major lead in male contraception. Gossypol is a polyphenolic compound present in the seed of the glandular variety of the cotton plant. Most of the basic and clinical studies in China and in other countries more recently, have been carried out with ...
M. R. N. Prasad, E. Diczfalusy
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Gossypol detoxification in the rumen and Helicoverpa armigera larvae: A review
Animal Nutrition, 2021 Gossypol, a phenolic compound found in the cotton plant, is widely distributed in cottonseed by-products. Although ruminant animals are believed to be more tolerant of gossypol toxicity than monogastric animals due to rumen microbial fermentation, the ...
Wei-Kang Wang +5 more
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Prenatal Exposure to Gossypol Impairs Corticogenesis of Mouse
Frontiers in Neuroscience, 2020 Gossypol is a yellow polyphenolic compounds extracted from roots, stems and seeds of cotton plants. Excessive intake of gossypol induces severe pathological signs of toxicity in livestock and wildlife.
Xiaoyan Zhu +6 more
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Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation
Clinical and Translational Science, 2023 Gossypol is a polyphenol from the cotton plant with anti‐inflammatory and anti‐oxidation activities and can also function as a histone deacetylase (HDAC) inhibitor. Sepsis is an inflammatory disease with high mortality.
Xiaohui Shi, Xinwei Lv, Dong Xiao
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(±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice [PDF]
, 2016 Racemic Gossypol [(±)-GOS], composed of both (-)-GOS and (+)-GOS, is a small BH3-mimetic polyphenol derived from cotton seeds. (±)-GOS has been employed and well tolerated by cancer patients. Head and neck carcinoma (HNC) represents one of the most fatal
Andracchio, Orlando +10 more
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BMC Plant Biology, 2023 Background Gossypol is a unique secondary metabolite and sesquiterpene in cotton, which is mainly synthesized in the root system of cotton and exhibits many biological activities.
Kun Ye +4 more
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Asian Pacific Journal of Tropical Biomedicine, 2021 Objective: To isolate, purify, and characterize gossypol from the fruits of Thespesia populnea (L) Sol. ex Correa, test its anti- dermatophytic activity, identify its targets on the dermatophyte, and confirm the binding of gossypol with the fungal target
R Anuthara +2 more
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PLoS ONE, 2020 The tolerance of ruminants to gossypol, a natural phenolic compound derived from the cotton plant, is greater than that of monogastric animals, partially because of the gossypol-degrading bacteria in the rumen of the ruminants. In this study, we aimed to
CaiDie Wang +4 more
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Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres
Biomolecules, 2019 Temozolomide is the current first-line treatment for glioblastoma patients but, because many patients are resistant to it, there is an urgent need to develop antitumor agents to treat temozolomide-resistant glioblastoma.
Hee Yeon Kim +8 more
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The embryotoxicity of gossypol [PDF]
Teratology, 1985 AbstractIn utero development was analyzed in pregnancies that resulted from matings between gossypol‐treated male rats and untreated female rats and in pregnancies in which gossypol was administered to the pregnant rat only. Gossypol treatment of males had no effect on the outcome of pregnancy.
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