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Ear, Nose & Throat Journal, 2008 INTRODUCTION: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions: What are the
Underwood, Martin
core +6 more sources
Circ_0058051 Targeted miR-129-5P Regulates Autophagy-Related Gene ATG7 to Promote the Inflammation of Gout [PDF]
Mediators of InflammationGout is a common autoinflammatory disease that clinically manifests as recurrent joint redness, swelling, and pain, but the molecular mechanism of recurrent gouty inflammation remains unclear.
Jianwei Guo +8 more
doaj +2 more sources
The Lancet, 2021 Gout is a common and treatable disease caused by the deposition of monosodium urate crystals in articular and non-articular structures. Increased concentration of serum urate (hyperuricaemia) is the most important risk factor for the development of gout.
Nicola, Dalbeth +3 more
openaire +4 more sources
Rheumatic Disease Clinics of North America, 2019 The treat to target strategy looks attractive for management of gout because it removes the causal mechanism inducing formation, growth, and aggregation of urate crystals. Further reduction of serum urate (sUA) levels below the threshold may dissolve crystals more rapidly. It is generally agreed that sUA less than 6 mg/dL is acceptable as a therapeutic
Fernando, Perez-Ruiz, Nicola, Dalbeth
+8 more sources
Frontiers in Microbiology, 2022 A high-purine diet can cause hyperuricemia and destroy the microbial composition of the gut microbiota. Both folic acid and zinc significantly reduce uric acid levels and alleviate hyperuricemia.
Xuewei Sun +15 more
doaj +1 more source
New England Journal of Medicine, 2023 To the Editor: The Clinical Practice review on gout by Mikuls (Nov. 17 issue)1 underscores the importance of hyperuricemia as a necessary risk factor and mentions the high heritability of serum urate levels.2 Serum urate levels are mostly controlled by the kidney, as confirmed by genetic studies implicating both rare and common variants in transporters
Devuyst, Olivier +2 more
openaire +4 more sources
Systematic Reviews, 2021 Background The Reporting Items for Practice Guidelines in Healthcare (RIGHT) checklist was used to assess the reporting quality of 2009–2019 clinical practice guidelines (CPGs) regarding gout and hyperuricemia, aimed to improve the reporting quality of ...
Can Wang +12 more
doaj +1 more source
Arthritis Research & Therapy, 2023 Background Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties.
Can Wang +14 more
doaj +1 more source
Effect of tart cherry juice on risk of gout attacks: protocol for a randomised controlled trial [PDF]
, 2020 Introduction: Gout is a painful form of inflammatory arthritis associated with several comorbidities, particularly cardiovascular disease. Cherries, which are rich in anti-inflammatory and antioxidative bioactive compounds, are proposed to be efficacious
Barker, Margo E +3 more
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Advances in Rheumatology, 2023 Objectives The deposition of monosodium urate (MSU) crystals within synovial joints and tissues is the initiating factor for gout arthritis. Thus, MSU crystals are a vital tool for studying gout’s molecular mechanism in animal and cellular models.
Fei Yan +9 more
doaj +1 more source