Results 1 to 10 of about 116,994 (206)

Gout [PDF]

Nature Reviews Disease Primers, 2019
The treat to target strategy looks attractive for management of gout because it removes the causal mechanism inducing formation, growth, and aggregation of urate crystals. Further reduction of serum urate (sUA) levels below the threshold may dissolve crystals more rapidly. It is generally agreed that sUA less than 6 mg/dL is acceptable as a therapeutic
Nicola Dalbeth, , Leo A B Joosten
exaly   +10 more sources

Effects of Citrate Mixture on Gout Flares During Urate-Lowering Therapy Initiation Among Chinese Male Underexcretion-Type Gout Patients: A Prospective Cohort Study [PDF]

Journal of Inflammation Research
Lingfang Xu,1,* Jidong Cheng,2,* Lingling Cui,1,* Kai Guo,1 Can Wang,1 Han Qi,2 Qian Zhang,2 Yuwei He,1 Xinde Li,1 Lin Han,1 Xuefeng Wang,1 Wenyan Sun,1 Xueyan Zhang,3 Mingshu Sun,4 Changgui Li,1,2,* Zhen Liu1,&ast ...
Xu L, Cheng J, Cui L, Guo K, Wang C, Qi H, Zhang Q, He Y, Li X, Han L, Wang X, Sun W, Zhang X, Sun M, Li C, Liu Z   +15 more
doaj   +2 more sources

Gout epidemiology and comorbidities

Seminars in Arthritis and Rheumatism, 2020
OBJECTIVE To review the epidemiology of gout and associated comorbidities. METHODS We review the key published studies of the epidemiology of gout and associated comorbidities. RESULTS The prevalence of gout ranged 1-4% worldwide and incidence ranged
Jasvinder A Singh, Angelo L Gaffo
exaly   +2 more sources

Gout

Annals of Internal Medicine
Gout is characterized by deposition of monosodium urate (MSU) crystals in or around joints, tendons, bursae, and other tissues, resulting in painful recurrent flares and tissue damage. Gout is the most common form of inflammatory arthritis, with a prevalence of 5.1% in the United States, affecting 12.1 million adults. When urate levels exceed the limit
Menon SG, Rednam M, Gujarathi R, Maher L.   +3 more
europepmc   +3 more sources

Gout [PDF]

The Lancet, 2021
Gout is a common and treatable disease caused by the deposition of monosodium urate crystals in articular and non-articular structures. Increased concentration of serum urate (hyperuricaemia) is the most important risk factor for the development of gout.
Nicola, Dalbeth, Anna L, Gosling, Angelo, Gaffo, Abhishek, Abhishek   +3 more
openaire   +4 more sources

Gout

New England Journal of Medicine, 2023
To the Editor: The Clinical Practice review on gout by Mikuls (Nov. 17 issue)1 underscores the importance of hyperuricemia as a necessary risk factor and mentions the high heritability of serum urate levels.2 Serum urate levels are mostly controlled by the kidney, as confirmed by genetic studies implicating both rare and common variants in transporters
Devuyst, Olivier, Olinger, Eric, Köttgen, Anna   +2 more
openaire   +4 more sources

Folic acid and zinc improve hyperuricemia by altering the gut microbiota of rats with high-purine diet-induced hyperuricemia

Frontiers in Microbiology, 2022
A high-purine diet can cause hyperuricemia and destroy the microbial composition of the gut microbiota. Both folic acid and zinc significantly reduce uric acid levels and alleviate hyperuricemia.
Xuewei Sun, Xuewei Sun, Jie Wen, Jie Wen, Baosheng Guan, Baosheng Guan, Jialin Li, Jialin Li, Jincheng Luo, Jincheng Luo, Jie Li, Jie Li, Mingyu Wei, Mingyu Wei, Hongbin Qiu, Hongbin Qiu   +15 more
doaj   +1 more source

Reporting quality of clinical practice guidelines regarding gout and hyperuricemia according to the RIGHT checklist: systematic review

Systematic Reviews, 2021
Background The Reporting Items for Practice Guidelines in Healthcare (RIGHT) checklist was used to assess the reporting quality of 2009–2019 clinical practice guidelines (CPGs) regarding gout and hyperuricemia, aimed to improve the reporting quality of ...
Can Wang, Xufei Luo, Maichao Li, Lingling Cui, Xinde Li, Lin Han, Xuefeng Wang, Wei Ren, Yuwei He, Wenyan Sun, Changgui Li, Yaolong Chen, Zhen Liu   +12 more
doaj   +1 more source

Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study

Arthritis Research & Therapy, 2023
Background Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties.
Can Wang, Wenyan Sun, Nicola Dalbeth, Zhongjun Wang, Xuefeng Wang, Xiaopeng Ji, Xiaomei Xue, Lin Han, Lingling Cui, Xinde Li, Zhen Liu, Aichang Ji, Yuwei He, Mingshu Sun, Changgui Li   +14 more
doaj   +1 more source

Global, Regional, and National Prevalence of Gout From 1990 to 2019: Age-Period-Cohort Analysis With Future Burden Prediction

JMIR Public Health and Surveillance, 2023
Background Gout is a common and debilitating condition that is associated with significant morbidity and mortality. Despite advances in medical treatment, the global burden of gout continues to increase, particularly in high–sociodemographic index (SDI ...
Qiyu He, T. Mok, Tat-Hang Sin, Jiaying Yin, Sicun Li, Yiyue Yin, Waikit Ming, B. Feng   +7 more
semanticscholar   +1 more source