Immunodiagnosis of paracoccidioidomycosis due to Paracoccidioides brasiliensis using a latex test: detection of specific antibody anti-gp43 and specific antigen gp43. [PDF]
PLoS Neglected Tropical Diseases, 2015 Paracoccidioidomycosis (PCM) is a life-threatening systemic disease and is a neglected public health problem in many endemic regions of Latin America.
Priscila Oliveira Dos Santos +5 more
doaj +23 more sources
scFv from Antibody That Mimics gp43 Modulates the Cellular and Humoral Immune Responses during Experimental Paracoccidioidomycosis. [PDF]
PLoS ONE, 2015 Paracoccidioidomycosis (PCM), caused by Paracoccidioides species is a prevalent systemic and progressive mycosis that occurs in Latin America. It is caused by Paracoccidioides species. Immunization with dendritic cells transfected with a plasmid encoding
Grasielle Pereira Jannuzzi +5 more
doaj +19 more sources
Peptides derived from gp43, the most antigenic protein from Paracoccidioides brasiliensis, form amyloid fibrils in vitro: implications for vaccine development [PDF]
Scientific Reports, 2021 Fungal infection is an important health problem in Latin America, and in Brazil in particular. Paracoccidioides (mainly P. brasiliensis and P. lutzii) is responsible for paracoccidioidomycosis, a disease that affects mainly the lungs.
Thyago R. Cardim-Pires +2 more
doaj +3 more sources
Journal of Immunology Research, 2019 The glycoprotein gp43 is the major antigenic/diagnostic component of Paracoccidioides brasiliensis, one of the etiologic agents of paracoccidioidomycosis (PCM). Gp43 has protective roles in mice, but due to adhesive properties, this glycoprotein has also
Taiane Priscila Gardizani +6 more
doaj +3 more sources
Saccharomyces cerevisiae expressing Gp43 protects mice against Paracoccidioides brasiliensis infection. [PDF]
PLoS ONE, 2015 The dimorphic fungus Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis (PCM). It is believed that approximately 10 million people are infected with the fungus and approximately 2% will eventually develop the disease. Unlike
Mariana Aprigio Assis-Marques +5 more
doaj +5 more sources
Paracoccidioides lutzii Plp43 is an active glucanase with partial antigenic identity with P. brasiliensis gp43. [PDF]
PLoS Neglected Tropical Diseases, 2014 Paracoccidioides brasiliensis and P. lutzii cause paracoccidioidomycosis (PCM). P. brasiliensis main diagnostic antigen is glycoprotein gp43, and its peptide sequence is 81% identical with a P. lutzii ortholog here called Plp43. P.
Natanael P Leitão +5 more
doaj +5 more sources
Inhibition of PbGP43 expression may suggest that gp43 is a virulence factor in Paracoccidioides brasiliensis. [PDF]
PLoS ONE, 2013 Glycoprotein gp43 is an immunodominant diagnostic antigen for paracoccidioidomycosis caused by Paracoccidioides brasiliensis. It is abundantly secreted in isolates such as Pb339. It is structurally related to beta-1,3-exoglucanases, however inactive. Its
Isaura Torres +8 more
doaj +7 more sources
Paracoccidioides brasiliensis GP43-derived peptides are potent modulators of local and systemic inflammatory response. [PDF]
Microbes and Infection, 2012 Paracoccidioidomycosis is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis. Its major antigen is a 43 kDa glycoprotein whose peptides embody different functions: P10 peptide, a T-cell epitope, :induces ...
F. T. Konno +7 more
semanticscholar +5 more sources
Utility of the Bacteriophage RB69 Polymerase gp43 as a Surrogate Enzyme for Herpesvirus Orthologs [PDF]
Viruses, 2013 Viral polymerases are important targets in drug discovery and development efforts. Most antiviral compounds that are currently approved for treatment of infection with members of the herpesviridae family were shown to inhibit the viral DNA polymerase ...
Nicholas Bennett, Matthias Götte
doaj +4 more sources
Detection of gp43 of Paracoccidioides brasiliensis by the loop-mediated isothermal amplification (LAMP) method. [PDF]
FEMS Microbiology Letters, 2004 Paracoccichoidomycosis is a deep mycosis Caused by the thermo-dependent dimorphic fungus Paracoccidioides brasiliensis and is prevalent in Latin American countries. We detected the species specific gp43 gene of P. brasiliensis by loop-mediated isothermal
Shigeo Endo +9 more
semanticscholar +7 more sources