Utility of the Bacteriophage RB69 Polymerase gp43 as a Surrogate Enzyme for Herpesvirus Orthologs [PDF]
Viruses, 2013 Viral polymerases are important targets in drug discovery and development efforts. Most antiviral compounds that are currently approved for treatment of infection with members of the herpesviridae family were shown to inhibit the viral DNA polymerase ...
Nicholas Bennett, Matthias Götte
exaly +5 more sources
Paracoccidioides lutzii Plp43 is an active glucanase with partial antigenic identity with P. brasiliensis gp43. [PDF]
PLoS Neglected Tropical Diseases, 2014 Paracoccidioides brasiliensis and P. lutzii cause paracoccidioidomycosis (PCM). P. brasiliensis main diagnostic antigen is glycoprotein gp43, and its peptide sequence is 81% identical with a P. lutzii ortholog here called Plp43. P.
Natanael P Leitão +5 more
doaj +4 more sources
Inhibition of PbGP43 expression may suggest that gp43 is a virulence factor in Paracoccidioides brasiliensis. [PDF]
PLoS ONE, 2013 Glycoprotein gp43 is an immunodominant diagnostic antigen for paracoccidioidomycosis caused by Paracoccidioides brasiliensis. It is abundantly secreted in isolates such as Pb339. It is structurally related to beta-1,3-exoglucanases, however inactive. Its
Isaura Torres +8 more
doaj +6 more sources
Paracoccidioides brasiliensis GP43-derived peptides are potent modulators of local and systemic inflammatory response [PDF]
Microbes and Infection, 2012 Paracoccidioidomycosis is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis. Its major antigen is a 43 kDa glycoprotein whose peptides embody different functions: P10 peptide, a T-cell epitope, :induces ...
Feitosa, Luciano dos Santos +7 more
core +4 more sources
Saccharomyces cerevisiae expressing Gp43 protects mice against Paracoccidioides brasiliensis infection. [PDF]
PLoS ONE, 2015 The dimorphic fungus Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis (PCM). It is believed that approximately 10 million people are infected with the fungus and approximately 2% will eventually develop the disease. Unlike
Mariana Aprigio Assis-Marques +5 more
doaj +4 more sources
The story of Paracoccidiodes gp43. [PDF]
Braz J Microbiol, 2023 This review is about Dr. Luiz Rodolpho Raja Gabaglia Travassos' scientific contributions to paracoccidioidomycosis as told by myself, Rosana Puccia, but co-written with Dr. Carlos P. Taborda, my younger scientific brother, collaborator, and dear friend. Dr.
Puccia R, Taborda CP.
europepmc +3 more sources
Paracoccidioides Species Circulating in the Endemic Area of Rio de Janeiro, Brazil: Updates into Their Genetic Diversity [PDF]
Journal of FungiParacoccidiodomycosis (PCM) is the most important systemic mycosis in Brazil, and is usually associated with rural work. PCM is caused by inhalation of infective propagules of thermodimorphic fungi from the genus Paracoccidioides.
Beatriz da Silva Motta +6 more
doaj +2 more sources
Influence of the Paracoccidioides brasiliensis 14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells [PDF]
Memorias do Instituto Oswaldo Cruz, 2015 The fungal strain Paracoccidioides brasiliensis remains viable inside of epithelial cells and can induce apoptosis in this population. However, until now, the molecules that participate in this process remained unknown.
Julhiany de Fátima da Silva +10 more
doaj +5 more sources
Paracoccidioides brasiliensis-gp43 used as paracoccidioidin [PDF]
Medical Mycology, 1996 A purified glycoprotein of 43,000 daltons from Paracoccidioides brasiliensis (gp43) was tested as paracoccidioidin in delayed-type hypersensitivity (DTH) tests in both experimental animals (guinea pig and mice) and patients with paracoccidioidomycosis (PCM). The gp43 paracoccidioidin was compared with the traditional Fava Netto antigen (AgFN).
Saraiva, E. C O +4 more
openaire +3 more sources
CNS Neuroscience &Therapeutics, Volume 29, Issue 2, Page 633-645, February 2023., 2023 Molecular hydrogen treatment can significantly improve the gut microbiota and metabolites and reduce the inflammatory reaction and cognitive dysfunction after SAE. This study provides a basis for the pathogenesis and treatment of SAE. Abstract Introduction In our experiments, male wild‐type mice were randomly divided into four groups: the sham, SAE ...
Qingqing Han +7 more
wiley +1 more source