Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica
In recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenuated bacterial vectors has become a promising ...
Marco Antonio Hernández-Luna +2 more
wiley +1 more source
Diagnosis of paracoccidioidomycosis by dot immunobinding assay for antibody detection using the purified and specific antigen gp43 [PDF]
The dot immunobinding assay, a rapid, visually read test, was adapted for serodiagnosis and follow-up of paracoccidioidomycosis (PCM). Purified gp43 antigen was tested before and after sodium metaperiodate treatment. To evaluate the assay, it was tested with sera from PCM, histoplasmosis, Jorge Lobo's disease, aspergillosis, candidiasis, and ...
Carlos Pelleschi Taborda, Z. P. Camargo
semanticscholar +3 more sources
Expression of glycoprotein gp43 in stage-specific forms and during dimorphic differentiation ofParacoccidioides brasiliensis [PDF]
Expression of the 43 kDa glycoprotein (gp43) was analysed in several Paracoccidioides brasiliensis isolates. Using one- and two-dimensional analysis of crude cellular extracts, it was shown that protein expression in yeast and mycelium was dependent on the isolate analysed. In two strains, in both yeast and mycelium cells.
R, Mattar-Filho +9 more
openaire +2 more sources
Background Paracoccidioides brasiliensis is a thermo-dimorphic fungus that causes paracoccidiodomycosis (PCM). Glycoprotein gp43 is the fungal main diagnostic antigen, which can also protect against murine PCM and interact with extracellular matrix ...
Puccia Rosana +2 more
doaj +1 more source
Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]
Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty +17 more
core +1 more source
Paracoccidioides Spp.: Virulence Factors and Immune‐Evasion Strategies
Paracoccidioides spp. are dimorphic fungal pathogens responsible for one of the most relevant systemic mycoses in Latin America, paracoccidioidomycosis (PCM). Their exact ecological niche remains unknown; however, they have been isolated from soil samples and armadillos (Dasypus novemcinctus), which have been proposed as animal reservoir for these ...
Emma Camacho +2 more
wiley +1 more source
Paracoccidioides cerebriformis Moore, 1935. MYCOLOGIC AND IMMUNOCHEMICAL STUDY
The present study concern on mycologic and immunochemical data obtained from two samples of a fungus considered as belonging to the species Paracoccidioides cerebriformis described by Moore in 1935, and maintained since then on Sabouraud’s agar in the ...
Carlos da Silva LACAZ +6 more
doaj +1 more source
DNA vaccine encoding peptide P10 against experimental paracoccidioidomycosis induces long-term protection in presence of regulatory T cells [PDF]
Paracoccidioidomycosis is a granulomatous systemic mycosis endemic in Brazil and other Latin America countries. A DNA vaccine encoding the inununoprotective peptide 10 (P10) significantly reduced the fungal burden in mice when given prior to or after ...
Amorim, Juliana de +6 more
core +2 more sources
Diseases caused by fungi can occur in healthy people, but immunocompromised patients are the major risk group for invasive fungal infections. Cases of fungal resistance and the difficulty of treatment make fungal infections a public health problem.
Juliana Alves Parente-Rocha +7 more
wiley +1 more source
Pereira, R. H. Study of the effects of the scFv therapy that mimics the Antigen of the conjugate Paracoccidioides brasiliensis gp43 conjugated nanocapsules in Paracoccidioidomycosis. 2015.
Roney Henrique Pereira
semanticscholar +1 more source

