Results 101 to 110 of about 92,511 (354)

Regulation of CXCR4 function by S1P1 through heteromerization

Cell Communication and Signaling
Background The trafficking of immune cells between lymphoid organs and circulation depends on gradients of CXCL12 and sphingosine-1-phosphate (S1P), mediated through their cognate receptors C-X-C chemokine receptor type 4 (CXCR4) and S1P receptor type 1 (
Hyun-Tae Kim, Jae-Yeon Jeong, Won-Ki Huh
doaj   +1 more source

The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations [PDF]

, 2020
Jakub Jakowiecki, Urszula Orzeł, Sathapana Chawananon, Przemysław Miszta, Sławomir Filipek   +4 more
openalex   +1 more source

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance This paper describes the finding that mitochondria synthesize and release melatonin and have their selective G protein-coupled receptor (GPCR) in the outer membrane.
Y. Suofu, Wei Li, F. Jean-Alphonse, J. Jia, Nicolas K. Khattar, Jiatong Li, S. Baranov, Daniela Leronni, A. C. Mihalik, Yanqing He, E. Cecon, Vanessa L. Wehbi, Jinho Kim, Brianna E. Heath, Oxana V. Baranova, Xiaomin Wang, Matthew J. Gable, E. Kretz, Giulietta Di Benedetto, T. Lezon, Lisa M. Ferrando, Timothy M. Larkin, M. Sullivan, S. Yablonska, Jingjing Wang, M. B. Minnigh, G. Guillaumet, F. Suzenet, R. M. Richardson, S. Poloyac, D. Stolz, R. Jockers, P. Witt‐Enderby, D. Carlisle, J. Vilardaga, R. Friedlander   +35 more
semanticscholar   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

Advanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li, Weijia Chen, Mengxue Sun, Xinbo Ni, Qishan Ran, Xiaoyu Hu, Fang Cao, Wenwen Zeng   +7 more
wiley   +1 more source

PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome

Nature Structural &Molecular Biology, 2015
G protein–coupled receptors (GPCRs) are essential mediators of cellular signaling and are important targets of drug action. Of the approximately 350 nonolfactory human GPCRs, more than 100 are still considered to be 'orphans' because their endogenous ...
W. Kroeze, M. F. Sassano, Xi-Ping Huang, K. Lansu, J. McCorvy, P. Giguère, N. Sciaky, B. Roth   +7 more
semanticscholar   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Functional GPCR expression in eukaryotic LEXSY system [PDF]

, 2023
Aleksandra Luginina, Ivan Maslov, Polina Khorn, Oleksandr Volkov, Andrey N Khnykin, Pavel Kuzmichev, M.B. Shevtsov, Anatoliy Belousov, Dmitrii Dashevskii, Daniil A. Kornilov, Ekaterina Bestsennaia, Johan Hofkens, Jelle Hendrix, Thomas Gensch, Vadim Cherezov, Valentin Ivanovich, Alexey Mishin, Valentin Borshchevskiy   +17 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Data-driven score tuning for ChooseLD: A structure-based drug design algorithm with empirical scoring and evaluation of ligand–protein docking predictability

Biophysics and Physicobiology
Computerized molecular docking methodologies are pivotal in in-silico screening, a crucial facet of modern drug design. ChooseLD, a docking simulation software, combines structure- and ligand-based drug design methods with empirical scoring.
Akihiro Masuda, Daichi Sadato, Mitsuo Iwadate   +2 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source