Results 121 to 130 of about 113,722 (335)
ChemMedChem, Accepted Article.We have described the synthesis of a new series of LCAPs (long‐chain arylpiperazine) as serotoninergic ligands (FG 1‐18). The combination of structural elements including heterocyclic nucleus, propyl chain and 4,5‐dihydrothiazol‐2‐ylphenylpiperazines, led to the preparation of different derivatives tested for their affinity toward 5‐HT1A, 5‐HT2A and 5 ...
Giorgia Andreozzi +18 more
wiley +1 more source
Open Veterinary JournalBackground: In 2021, Vietnam experienced an outbreak of Lumpy skin disease (LSD), which infected 207,687 cattle and buffaloes, as officially reported, and resulted in the culling of 29,182 animals.
Ha Thi Thanh Tran +5 more
doaj +1 more source
Chipping away at GPCR function [PDF]
, 1999 Kevin Beaumont, Paul A. Negulescu
openalex +1 more source
ChemMedChem, Accepted Article.Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore +5 more
wiley +1 more source
Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding [PDF]
, 2018 Activation of heterotrimeric G proteins is a key step in many signaling cascades. However, a complete mechanism for this process, which requires allosteric communication between binding sites that are ~30 Å apart, remains elusive.
Blumer, Kendall J +3 more
core +1 more source
Understanding GPCR dimerization
, 2019 Initially G protein-coupled receptors, GPCRs, were thought to act as monomers, but recently strong evidence has been gathered indicating that they are capable of forming homo- and heterodimers or higher order oligomeric complexes, and that the dimerization phenomenon can modulate the pharmacological response and function of these receptors.
Faron-Górecka, Agata +7 more
openaire +4 more sources
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
NCD3G: a novel nine-cysteine domain in family 3 GPCRs [PDF]
, 2004 Xiang-hua Liu +5 more
openalex +2 more sources
G Protein-coupled receptors as targets for drug design
Biotecnología AplicadaG protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today,
Ania de la Nuez Veulens +1 more
doaj
Editorial: Insights in cellular endocrinology: 2022
Frontiers in Endocrinology, 2023 Ralf Jockers, Oreste Gualillo
doaj +1 more source