Molecular bases of insect odorant receptor function: specificity and evolution
Biological Reviews, EarlyView.ABSTRACT Insect odorant receptors (ORs) are a class of chemoreceptors that insects use to detect volatile cues in their environment. In recent years, major advances in the field of structural biology have made it possible to obtain the first structures of insect ORs.
Zibo Li +5 more
wiley +1 more source
Expression patterns of C1ql4 and its cell‐adhesion GPCR Bai3 in the murine testis and functional roles in steroidogenesis [PDF]
, 2019 Anni Tan +8 more
openalex +1 more source
Biotechnology Progress, EarlyView.Abstract Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membrane protrusions at the cell front side and adhesion disassembly at the rear side, and a general ...
Antonio Mazzei +5 more
wiley +1 more source
Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies
Chemistry – A European Journal, EarlyView.This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley +1 more source
The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery
EngineeringG protein-coupled receptors (GPCRs) are crucial players in various physiological processes, making them attractive candidates for drug discovery. However, traditional approaches to GPCR ligand discovery are time-consuming and resource-intensive.
Wei Chen +4 more
doaj +1 more source
Three-dimensional descriptors for aminergic GPCRs: dependence on docking conformation and crystal structure [PDF]
, 2018 Stanisław Jastrzȩbski +5 more
openalex +1 more source
Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS
Clinical Pharmacology &Therapeutics, EarlyView.Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli +5 more
wiley +1 more source
Food Bioengineering, EarlyView.ABSTRACT Artificial intelligence (AI) has emerged as a paradigm‐shifting force in enzyme engineering, enabling data‐driven prediction of catalytic activity, stability, and substrate specificity. By integrating large‐scale datasets from structured databases (e.g., PDB, BRENDA) and high‐throughput experimentation (e.g., deep mutational scanning ...
Xiafeng Lu +11 more
wiley +1 more source
Revolution in
, 2014 Wakako Fujita +2 more
openalex +1 more source
Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain [PDF]
, 2019 Jeffri S. Retamal +4 more
openalex +1 more source