Results 121 to 130 of about 61,419 (246)
A Chemogenetic Toolkit for Inducible, Cell Type‐Specific Actin Disassembly
Small Methods, EarlyView.ChiActs are novel actin‐perturbing genetic tools that can be rapidly activated by chemical actuators and optogenetically targeted to distinct subcellular locations using light. ChiActs rapidly induce actin disassembly in several model cell types and are able to perturb actin‐dependent nano‐assembly and cellular functions, including inhibition of ...
Tien‐Hung Lan +5 more
wiley +1 more source
Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy
VIEW, EarlyView.The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang +11 more
wiley +1 more source
Proteomic applications of automated GPCR classification [PDF]
, 2007 Matthew N. Davies +6 more
openalex +1 more source
Ogerin induced activation of Gpr68 alters tendon healing
FASEB BioAdvances, EarlyView.Ogerin, a positive allosteric modulator of Gpr68, inhibits myofibroblast differentiation and promotes the reversion of mature myofibroblasts to a basal tendon fibroblast state in vitro. In vivo, Ogerin treatment during early tendon healing improves mechanical properties and alters the transcriptional profile toward increased matrix remodeling, although
Andrew Rodenhouse +9 more
wiley +1 more source
European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022 Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna +3 more
wiley +1 more source
Plasmon-waveguide resonance (PWR) spectroscopy for directly viewing rates of GPCR/G-protein interactions and quantifying affinities [PDF]
, 2007 Victor J. Hruby, Gordon Tollin
openalex +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To determine the effect of propranolol on myometrial contractions induced by low dose and high dose oxytocin. Design Prospective ex vivo laboratory study. Setting Mount Sinai Hospital, Toronto. Population Full‐term parturients who underwent elective caesarean deliveries (CD).
Mrinalini Balki +5 more
wiley +1 more source
Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor [PDF]
, 2007 Jennifer Alexander‐Brett +1 more
openalex +1 more source
DREADDs‐Based Chemogenetics Induced Slow Transit Constipation via Inhibition of Enteric Neurons
Journal of Digestive Diseases, EarlyView.Designer receptors exclusively activated by designer drugs (DREADDs)‐based chemogenetic tools were used to induce murine model of slow transit constipation. Adeno‐associated virus (AAV) 9‐hM4Di or normal saline (control) was injected into six sites spread out over the whole colon of mice, and the indicators of colonic motility were evaluated after ...
Xin Yi Lu +9 more
wiley +1 more source