Results 131 to 140 of about 61,419 (246)

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits

Experimental Dermatology, Volume 31, Issue 12, Page 1900-1907, December 2022., 2022
Abstract Modern genetic approaches in animal models have unveiled novel itch‐specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years, kappa‐opioid receptors (KORs) and mu‐opioid receptors (MORs) have been implicated in both the ...
Brian S. Kim, Saadet Inan, Sonja Ständer, Thomas Sciascia, Jacek C. Szepietowski, Gil Yosipovitch   +5 more
wiley   +1 more source

SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer. [PDF]

J Transl Med
Zhuang J, Wang Y, Wu X, Peng Z, Huang Z, Zhao C, Shen B.   +6 more
europepmc   +1 more source

GPCR functional selectivity has therapeutic impact [PDF]

, 2007
Richard B. Mailman
openalex   +1 more source

Structural basis for cholesterol sensing of LYCHOS and its interaction with indoxyl sulfate. [PDF]

Nat Commun
Wang Z, He J, Yang Y, He Y, Qian H.
europepmc   +1 more source

The cell biology of Smo signalling and its relationships with GPCRs

, 2006
Ana Ruiz‐Gómez, Cristina Molnar, Helena Holguín, Federico Mayor, José F. de Celis   +4 more
openalex   +1 more source

Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR) [PDF]

, 2007
Jeremiah Stitham, Eric Arehart, Scott Gleim, Karen Douville, Todd A. MacKenzie, John Hwa   +5 more
openalex   +1 more source

Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice

Aging Cell, EarlyView.
The diminished function of endothelial TRPV4, rather than changes in its expression, plays a significant role in aging‐related endothelial dysfunction. The interaction between TRPV4 and GPR35 significantly contributes to this condition. Blocking the TRPV4‐GPR35 interaction with Thonningianin A or Carfilzomib represents a promising precision approach ...
Xiaoxue Tian, Hao Kan, Liu Yang, Zhiwei Wang, Tiantian Zhang, Ka Zhang, Aiqin Mao, Xin Wen, Tingting Zhou, Xiaoyan Wang, Xiaodong Zhang, Lei Feng, Li Geng   +12 more
wiley   +1 more source

To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract. [PDF]

World J Gastroenterol
Cui ZJ.
europepmc   +1 more source

Author Correction: Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration

Scientific Reports
Chulo Park, Jin‑Woo Lee, Kiheon Kim, Dong‑Seung Seen, Jae‑Yeon Jeong, Won‑Ki Huh   +5 more
doaj   +1 more source

The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery

Engineering
G protein-coupled receptors (GPCRs) are crucial players in various physiological processes, making them attractive candidates for drug discovery. However, traditional approaches to GPCR ligand discovery are time-consuming and resource-intensive.
Wei Chen, Chi Song, Liang Leng, Sanyin Zhang, Shilin Chen   +4 more
doaj