Results 191 to 200 of about 61,419 (246)

Genetic variants of accessory proteins and G proteins in human genetic disease. [PDF]

Crit Rev Clin Lab Sci
Thompson MD, Chidiac P, Jose PA, Hauser AS, Gorvin CM.   +4 more
europepmc   +1 more source

Is helix VIII of G protein‐coupled receptors (GPCRs) a lipid‐activated signalling sensor?

, 2007
John Huynh, Leonard K. Pattenden, Marie‐Isabel Aguilar, Walter G. Thomas   +3 more
openalex   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

CXC Chemokine Ligand 12 Facilitates Gi Protein Binding to CXC Chemokine Receptor 4 by Stabilizing Packing of the Proline-Isoleucine-Phenylalanine Motif: Insights from Automated Path Searching. [PDF]

J Am Chem Soc
Li X, Liu Y, Liu J, Ma W, Ti R, Warshel A, Ye RD, Zhu L.   +7 more
europepmc   +1 more source

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel, Zeenat Zara, Alessandro Nicoli, Alexandra Steuer, Marta Lopez‐Balastegui, Jana Selent, Sanjai Karanth, Melanie Koehler, Antonella Ciancetta, Layara Akemi Abiko, Franz Hagn, Antonella Di Pizio   +11 more
wiley   +1 more source

Epitope-directed selection of GPCR nanobody ligands with evolvable function. [PDF]

Proc Natl Acad Sci U S A
Skiba MA, Canavan C, Nemeth GR, Liu J, Kanso A, Kruse AC.   +5 more
europepmc   +1 more source

Multiplexed Assays by High-Content Imaging for Assessment of GPCR Activity

, 2008
D. A. Ross, S. Lee, Vladimı́r Reiser, Junli Xue, K. Alves, Sravanti Vaidya, Anthony Kreamer, Rebecca Mull, Ed Hudak, Terri Hare, P A Detmers, R. B. Lingham, Marc Ferrer, Berta Strulovici, Francesca Santini   +14 more
openalex   +1 more source

Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

British Journal of Pharmacology, EarlyView.
Background and Purpose The pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk, Merle F. Sternschulte, Oliver Soehnlein, Marcel Bermudez, Carsten A. Raabe, Ursula Rescher   +5 more
wiley   +1 more source

Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator. [PDF]

Cell Res
Sun D, Li X, Yuan Q, Wang Y, Shi P, Zhang H, Wang T, Sun W, Ling S, Liu Y, Lai J, Xie W, Yin W, Liu L, Xu HE, Tian C.   +15 more
europepmc   +1 more source

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, EarlyView.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source