Results 201 to 210 of about 92,178 (306)

The receptor‐like pseudokinase LENG stimulates chilling tolerance in rice by inhibiting the activity of the OsCRPK1‐OsGF14d module

Journal of Integrative Plant Biology, EarlyView.
The rice receptor‐like pseudokinase LENG enhances chilling tolerance by binding to and suppressing the kinase activity of OsCRPK1, thereby preventing OsCRPK1‐mediated phosphorylation of the cold‐tolerance positive regulator OsGF14d. ABSTRACT Cold damage during the seedling and reproductive stages has a pronounced impact on rice development and yield ...
Shuting Yuan, Chunjue Xu, Xia Wang, Wei Yan, Xiaojie Hua, Yi Zhuang, Cuifang Wang, Changjian Wang, Yihang Gong, Jianxin Wu, Letian Chen, Xiaoyan Tang, Wenbo Pan   +12 more
wiley   +1 more source

Integrated Analysis of ATAC-Seq and RNA-Seq Reveals the Signal Transduction Regulation of the Molting Cycle in the Muscle of Chinese Mitten Crab (Eriocheir sinensis). [PDF]

Biomolecules
He Z, Li J, Zhang J, Zhang R, Tan R, Sun J, Wang B, Hao T.   +7 more
europepmc   +1 more source

GPCR-SAS

G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. They mediate signal transduction across cell membranes and are important targets for the pharmaceutical industry. The G Protein-Coupled Receptors-Sequence Analysis and Statistics (GPCR-SAS) web application provides a set of tools to perform comparative analysis of ...
Gómez-Tamayo, José Carlos||, Olivella, Mireia||, Ríos, Santiago, Hoogstraat, Marlous, Gonzalez, Angel||, Mayol, Eduardo||, Deupi, Xavier||, Campillo Grau, María Mercedes||, Cordomí Montoya, Arnau||   +8 more
openaire   +1 more source

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Journal of Periodontal Research, EarlyView.
BDMP, a peptide that can penetrate cells and tissues, offering antimicrobial and anti‐inflammatory effects, has been identified as a potential new therapy for periodontitis. ABSTRACT Aim This study evaluated the potential of a beta‐defensin‐3 mimetic peptide (BDMP), a synthetic cell‐penetrating peptide with antimicrobial and immunomodulatory properties,
Beom Soo Jo, Dong Woo Lee, Ji‐Young Lee, Sanghui Seok, Yu‐Bin Kim, Jue‐Yeon Lee, Shin‐Young Park, Young Dan Cho, Yang Jo Seol, Yoon Shin Park, Shahram Ghanaati, Homayoun H. Zadeh, Chong Pyung Chung, Yoon Jeong Park   +13 more
wiley   +1 more source

Constitutive activity among orphan G protein-coupled receptors: Molecular mechanisms and pharmacological perspectives. [PDF]

Mol Pharmacol
Murphy RE, Smith HR, Allen JA.
europepmc   +1 more source

An online resource for GPCR structure determination and analysis

Nature Methods, 2019
Christian Munk, Eshita Mutt, Vignir Ísberg, Louise F. Nikolajsen, J. M. Bibbe, T. Flock, M. Hanson, R. Stevens, X. Deupí, David E. Gloriam   +9 more
semanticscholar   +1 more source

H3K27me3‐Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion

Plant Biotechnology Journal, EarlyView.
ABSTRACT Histone H3 lysine 27 trimethylation (H3K27me3) is essential for fungal pathogenicity, yet its contribution to pathogen–host interactions remains incompletely understood. Here, we profiled H3K27me3 dynamics in Fusarium graminearum during infection and identified 132 H3K27me3‐marked genes (FgHMGs).
Xiaozhen Zhao, Bingqin Yuan, Peixue Ma, Yajie Cai, Yan Huang, Yaxuan Wang, Zhen Cheng, Yuan Chen, Minghong Zheng, Ran Zhang, Jinmei Wu, Xieyu Li, Mohan Wang, Huijun Wu, Chengqi Zhang, Xuewen Gao, Li Chen, Qin Gu   +17 more
wiley   +1 more source

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

Nature reviews. Drug discovery, 2018
I. Shimada, Takumi Ueda, Yutaka Kofuku, M. Eddy, K. Wüthrich   +4 more
semanticscholar   +1 more source

Immunomodulatory effects of cathelicidin in the gut–brain axis: A novel link between mucosal immunity and neuroinflammation

Experimental Physiology, EarlyView.
Abstract Cathelicidins are evolutionarily conserved host defence peptides known for their dual antimicrobial and immunomodulatory functions. Among them, LL‐37 in humans and CRAMP in rodents have emerged as crucial regulators of both mucosal immunity and CNS inflammation.
Mehrdad Nourizadeh, Amir Arsalan Ghahari, Ehsan Zandi, Seyedeh Zeynab Rasouli, Shaghayegh Davari, Mobina Hoseinzadeh, Mir Alireza Nourazar   +6 more
wiley   +1 more source