Results 201 to 210 of about 61,419 (246)

Evolutionary scenarios for the specific recognition of nonhomologous endogenous peptides by G protein-coupled receptor paralogs. [PDF]

J Biol Chem
Shiraishi A, Wada A, Satake H.
europepmc   +1 more source

Physicochemical properties of GPCR amino acid sequences for understanding GPCR-G-protein coupling

, 2008
Ganga D. Ghimire, Hideki Tanizawa, Masashi Sonoyama, Shigeki Mitaku   +3 more
openalex   +2 more sources

A bio. tools collection of online resources for GPCR research

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options.
Tõnis Laasfeld, Friederike Wunsch, Avgi E. Apostolakou, Adrián García‐Recio, Gáspár Pándy‐Szekeres, Slawomir Filipek, Masha Y. Niv, Jana Selent, David E. Gloriam, Marcel Bermudez   +9 more
wiley   +1 more source

Is GCR1 the GPR157 of plants? [PDF]

Plant Physiol
Gotkhindikar A, Chakravorty D, Sengupta D, Joshi M, Assmann SM.   +4 more
europepmc   +1 more source

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain, Dingxin Pan, Kate L. Arkless, Khondaker Miraz Rahman, Clive P. Page, Kalwant S. Authi, Simon C. Pitchford   +6 more
wiley   +1 more source

Ligand-Independent Spontaneous Activation of Purinergic P2Y₆ Receptor Under Cell Culture Soft Substrate. [PDF]

Cells
Nishimura A, Nishiyama K, Ito T, Mi X, Kato Y, Inoue A, Aoki J, Nishida M.   +7 more
europepmc   +1 more source

Efficacy of IDOR‐1117‐2520, a novel, orally available CCR6 antagonist in preclinical models of skin dermatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose The chemokine receptor CCR6 guides pathogenic T17 cells, implicated in autoimmune diseases including psoriasis, to sites of inflammation via the chemokine CCL20. Therefor, pharmacological inhibition of CCR6+ immune cell migration provides a novel therapeutic approach.
Paulina Kulig, Pijus Brazauskas, Madeleine Suffiotti, Emilie Raoult, Ulrike Babilonski, Bérengère Renault, Ursula Grieder, Enrico Vezzali, Peter Blattmann, Marianne M. Martinic, Mark J. Murphy   +10 more
wiley   +1 more source

Molecular Glues: A New Approach to Modulating GPCR Signaling Bias. [PDF]

Biochemistry
Kushnir J, Gumpper RH.
europepmc   +1 more source

Elucidation of signaling and functional activities of an orphan GPCR, GPR81

, 2008
Hongfei Ge, Jennifer Weiszmann, Jeff D. Reagan, Jamila Gupte, Hélène Baribault, Tibor Gyuris, Jinlong Chen, Hui Tian, Yang Li   +8 more
openalex   +1 more source

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source