Results 201 to 210 of about 92,511 (354)

Editorial: GPCRs and Cancer [PDF]

Frontiers in Genetics, 2017
Suzie Chen, Suzie Chen
openaire   +3 more sources

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

Clinical Genetics, EarlyView.
Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré, Nicolas Bourgon, Dhruvin Akbari, Jeanne Porée, Valentina Serpieri, Marine Panza, Lynda Haddad, Patrick Nitschké, Jacqueline Aziza, Cristina Matt, Enza Maria Valente, Patricia Gargallo, Charlotte Dubucs, Tania Attié‐Bitach, Michel R. Leroux, Sophie Thomas   +19 more
wiley   +1 more source

Deep learning reveals endogenous sterols as allosteric modulators of the GPCR-Gα interface. [PDF]

Elife
Mohanty SK, Mittal A, Farooqi N, Gaur A, Duari S, Solanki S, Sharma AK, Arora S, Kumar S, Gautam V, Dixit NK, Subramanian K, Ghosh TS, Sengupta D, Gupta SK, Murugan AN, Sharma D, Ahuja G.   +17 more
europepmc   +1 more source

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

Decoding missense variants pleiotropy in the immune GPCR P2RY8. [PDF]

Cell Genom
Shen S, Luo R, Shao Z.
europepmc   +1 more source

Antagonist binding and induced conformational dynamics of GPCR A_2A adenosine receptor [PDF]

, 2013
Xueqin Pang, Mingjun Yang, Keli Han
openalex   +1 more source

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

The FEBS Journal, EarlyView.
Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos   +6 more
wiley   +1 more source

A yeast mating platform for multiplex screening of fungal GPCR-ligand interactions. [PDF]

Proc Natl Acad Sci U S A
Schiesaro G, Mariscal M, Jönsson M, Tenente R, Sørensen MB, Wäneskog M, Aguilar-Pontes MV, Undabarrena A, Deichmann M, Hoch-Schneider EE, Kandasamy V, Frimurer TM, Di Pietro A, Clemmensen LKH, Krogh Jensen M, Jensen ED.   +15 more
europepmc   +1 more source

Modeling GPCR-induced biased signalingTowards a system biology definition of drugs selectivity

, 2020
Romain Yvinec
openalex   +1 more source

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

The FEBS Journal, EarlyView.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima, Sayako Shimomura, Mayuka Wakabayashi, Wei Qi Loh, Harumi Ando, Haruka Sei, Hiroyuki Hattori, Didik Huswo Utomo, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata   +11 more
wiley   +1 more source