Results 201 to 210 of about 113,722 (335)

Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR) [PDF]

, 2007
Jeremiah Stitham, Eric Arehart, Scott Gleim, Karen Douville, Todd A. MacKenzie, John Hwa   +5 more
openalex   +1 more source

Intracellular GPCR modulators enable precision pharmacology. [PDF]

NPJ Drug Discov
Krumm BE, Roth BL.
europepmc   +1 more source

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, EarlyView.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source

BRET analysis of GPCR oligomerization: newer does not mean better

, 2006
Michel Bouvier, Nikolaus Heveker, Ralf Jockers, Stéfano Marullo, Graeme Milligan   +4 more
openalex   +2 more sources

Manifold active‐state conformations in GPCRs: Agonist‐activated constitutively active mutant AT₁ receptor preferentially couples to Gq compared to the wild‐type AT₁ receptor [PDF]

, 2007
ChangWoo Lee, Si Ae Hwang, Sei-Heon Jang, Hye-Shin Chung, Manjunatha B. Bhat, Sadashiva S. Karnik   +5 more
openalex   +1 more source

Identification and Expression Analysis of G-Protein-Coupled Receptors Provide Insights into Functional and Mechanistic Responses to Herbivore-Induced Plant Volatiles of <i>Paracarophenax alternatus</i>. [PDF]

Int J Mol Sci
Lin R, Chu X, Zhang Y, Ke S, Zheng Y, Yu W, Zhang F, Wu S.   +7 more
europepmc   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

Genome-wide pan-GPCR cell libraries accelerate drug discovery

Acta Pharmaceutica Sinica B
G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery.
Hanting Yang, Yongfu Wang, Wei Liu, Taiping He, Jiayu Liao, Zhongzhi Qian, Jinghao Zhao, Zhaotong Cong, Dan Sun, Zhixiang Liu, Can Wang, Lingping Zhu, Shilin Chen   +12 more
doaj  

The cell biology of Smo signalling and its relationships with GPCRs

, 2006
Ana Ruiz‐Gómez, Cristina Molnar, Helena Holguín, Federico Mayor, José F. de Celis   +4 more
openalex   +1 more source

SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer. [PDF]

J Transl Med
Zhuang J, Wang Y, Wu X, Peng Z, Huang Z, Zhao C, Shen B.   +6 more
europepmc   +1 more source