Results 221 to 230 of about 113,722 (335)

Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor [PDF]

, 2008
Jo Ann Janovick, Akshay Patny, Ralph Mosley, Mark T. Goulet, Michael D. Altman, Thomas S. Rush, Anda Cornea, P. Michael Conn   +7 more
openalex   +1 more source

Gram-negative bacteria activate cellular pathways in plaque microenvironment; Systems biology approach. [PDF]

BMC Microbiol
Ganjali R, Elahimanesh M, Aghazadeh H, Najafi M.   +3 more
europepmc   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

1P478 Sequence and structure features of GPCRs, which are effective to determine the GPCR and G-protein binding selectivity(23. Bioinformatics, genomics and proteomics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

, 2006
Makiko Suwa, Takahiko Muramatsu
openalex   +2 more sources

Comparison on Functional Assays for Gq-Coupled GPCRs by Measuring Inositol Monophospate-1 and Intracellular Calcium in 1536-Well Plate Format [PDF]

, 2008
Ke Liu, Steve Titus, Noel Southall, Pingjun Zhu, James Inglese, Christopher P. Austin, Wei Zheng   +6 more
openalex   +1 more source

GPCR Engineering Yields High-Resolution Structural Insights into β ₂ -Adrenergic Receptor Function

, 2007
Daniel M. Rosenbaum, Vadim Cherezov, Michael A. Hanson, Søren G. F. Rasmussen, Foon Sun Thian, Tong Sun Kobilka, Hee‐Jung Choi, Xiao-Jie Yao, William I. Weis, Raymond C. Stevens, Brian K. Kobilka   +10 more
openalex   +1 more source

The Effect of Deletion of the Orphan G – Protein Coupled Receptor (GPCR) Gene MrgE on Pain-Like Behaviours in Mice [PDF]

, 2008
Peter J. Cox, Tom Pitcher, Steven A. Trim, Christine H Bell, Wenning Qin, Ross A. Kinloch   +5 more
openalex   +1 more source

Early Origins of Asthma and Allergies: Clues From Studies in China

Clinical &Experimental Allergy, EarlyView.
The environment we live in harbours both risk and protective factors for asthma and allergies. This is particularly relevant in China, where unique environmental and cultural factors shape disease development. The interplay between these environmental factors, airway immunity, and gut microbiome shapes the susceptibility to asthma and allergies ...
Yike Wang, Jing Yang, Xueling Lai, Agnes Sze‐Yin Leung, Yuhan Xing, Gary Wing‐Kin Wong   +5 more
wiley   +1 more source

Structural features of arrestin-mediated GPCR signaling

Medicine in Drug Discovery
G protein-coupled receptors (GPCRs) constitute a diverse and extensive array of cell surface receptors, rendering them essential targets for drugs aimed at various human diseases.
Wenqin Xie, Jinglin Lai, Hongmin Cai, H. Eric Xu, Wanchao Yin   +4 more
doaj  

G_zESTY as an optimized cell-based assay for initial steps in GPCR deorphanization. [PDF]

Nat Commun
Franchini L, Porter JJ, Lueck JD, Orlandi C.   +3 more
europepmc   +1 more source