Results 221 to 230 of about 61,419 (246)

AGS3-based optogenetic GDI induces GPCR-independent Gβγ signalling and macrophage migration. [PDF]

Open Biol
Thotamune W, Ubeysinghe S, Rajarathna C, Kankanamge D, Olupothage K, Chandu A, Copits BA, Karunarathne A.   +7 more
europepmc   +1 more source

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin

, 2009
Thomas E. Angel, Sayan Gupta, Beata Jastrzȩbska, Krzysztof Palczewski, Mark R. Chance   +4 more
openalex   +1 more source

Inflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomics insight

Equine Veterinary Journal, EarlyView.
Abstract Background Equine dental diseases significantly impact a horse's overall health, performance and quality of life. They can result in secondary infections and digestive disturbances, potentially leading to colic. A recently described disease affecting the incisors of horses is equine odontoclastic tooth resorption and hypercementosis (EOTRH ...
Anders Jensen, Emily J. Clarke, Zoe Nugent, Emily Paice, Iris Gringel, Kazuhiro Yamamoto, Guido Rocchigiani, Andrew J. Peffers, Lee Cooper, Mandy J. Peffers   +9 more
wiley   +1 more source

A New GRK2 Inhibitor for Heart Failure. [PDF]

JACC Basic Transl Sci
Gao C, Song N, Wang Y.
europepmc   +1 more source

Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human pancreas reveals a role for GPR56 in islet development. [PDF]

Cell Mol Life Sci
Olaniru OE, Toczyska K, Guccio N, Giera S, Piao X, King AJF, Jones PM, Persaud SJ.   +7 more
europepmc   +1 more source

Physical and functional interactions between LDLR family members and CXCR4 in breast cancer

The FEBS Journal, EarlyView.
Here, we demonstrate that members of the low‐density lipoprotein receptor (LDLR) family can regulate C‐X‐C chemokine receptor type 4 (CXCR4) signaling and therefore affect CXCR4‐induced breast cancer metastasis. We found that very low‐density lipoprotein receptor (VLDLR), low‐density lipoprotein receptor‐related protein 8 (LRP8) and apolipoprotein E ...
Jiankang Zhang, Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Dan‐ni Ren, Weidong Zhu   +7 more
wiley   +1 more source

Agonist efficacy at the β₂AR is driven by the faster association rate of the G_s protein. [PDF]

Front Pharmacol
Harwood CR, Sykes DA, Redfern-Nichols T, Underwood O, Nicholson C, Khoshgrudi AN, Koers EJ, Ladds G, Briddon SJ, Veprintsev DB.   +9 more
europepmc   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Beyond the classic GPCR: unraveling the role of GPR155 role in cholesterol sensing and signaling. [PDF]

Signal Transduct Target Ther
Schöneberg T.
europepmc   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source