Intracellular Receptor Modulation: Novel Approach to Target GPCRs [PDF]
, 2018 Natalia V. Ortiz Zacarı́as +4 more
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Therapeutic advances in pruritus as a model of personalized medicine
Journal of the European Academy of Dermatology and Venereology, EarlyView.Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung +2 more
wiley +1 more source
Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling. [PDF]
PLoS BiolSachdev S, Roy S, Cheloha RW.
europepmc +1 more source
To grow or not to grow: NRT1.1B as a dual receptor for ABA and nitrate
Journal of Integrative Plant Biology, EarlyView.This Commentary highlights research showing that NRT1.1B acts as a dual receptor for nitrate and abscisic acid, enabling plants to balance growth and stress responses. By integrating nutrient and hormone signals, this mechanism explains how plants decide whether to continue or stop growing under fluctuating environmental conditions.
Soichi Kojima, Makoto Matsuoka
wiley +1 more source
Author Correction: A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR. [PDF]
Nat Struct Mol BiolMighell TL, Lehner B.
europepmc +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
The multifaceted roles of ketones in physiology
Experimental Physiology, EarlyView.Abstract The production of ketones, referred to as ketogenesis, plays an essential role in maintaining energy homeostasis during prolonged fasting/starvation, which primarily stems from its ability to serve as a fuel source to support neuronal ATP production, thereby limiting muscle wasting. Over the years, the field has come to appreciate that ketones
Seyed Amirhossein Tabatabaei Dakhili +3 more
wiley +1 more source
The Glyco-Switch of life: O-GlcNAcylation in cell fate decision. [PDF]
GlycobiologyWang A, Young M, Jiang J.
europepmc +1 more source
Human GPCR Interactome and Investigation of the KCTD/beta2-adrenergic Receptor Interactions
, 2014 Ekaterina Sokolina
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