Results 31 to 40 of about 92,511 (354)
Latrophilin GPCR signaling mediates synapse formation
bioRxiv, 2021 Neural circuit assembly in the brain requires precise establishment of synaptic connections, but the mechanisms of synapse assembly remain incompletely understood.
Richard C. Sando, T. Südhof
semanticscholar +1 more source
The role of structural dynamics in GPCR‐mediated signaling
The FEBS Journal, 2021 G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human physiology in response to a wide array of different extracellular stimuli and thus represent one of the largest groups of therapeutic drug targets.
D. Hilger
semanticscholar +1 more source
Arrestin-3 differentially regulates platelet GPCR subsets
Platelets, 2020 The principal demonstrated role of the nonvisual arrestins in vivo is to limit G protein-coupled receptor (GPCR) signaling. Nonetheless, a direct demonstration of this fundamental ability in platelets remains lacking, despite the prominent role played by
James L. Hutchinson +3 more
doaj +1 more source
Update on GPCR-based targets for the development of novel antidepressants
Molecular Psychiatry, 2021 Traditional antidepressants largely interfere with monoaminergic transport or degradation systems, taking several weeks to have their therapeutic actions. Moreover, a large proportion of depressed patients are resistant to these therapies.
I. Mantas +3 more
semanticscholar +1 more source
The Secretin GPCRs Descended from the Family of Adhesion GPCRs [PDF]
Molecular Biology and Evolution, 2008 The Adhesion G-protein-coupled receptors (GPCRs) are the most complex gene family among GPCRs with large genomic size, multiple introns, and a fascinating flora of functional domains, though the evolutionary origin of this family has been obscure. Here we studied the evolution of all class B (7tm2)-related genes, including the Adhesion, Secretin, and ...
Karl J V, Nordström +4 more
openaire +2 more sources
Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey
Cells, 2019 Ligand-activated plasma membrane receptors follow pathways of endocytosis through the endosomal sorting apparatus. Receptors cluster in clathrin-coated pits that bud inwards and enter the cell as clathrin-coated vesicles.
Caitrin Crudden +7 more
doaj +1 more source
Agonist and antagonist TRUPATH assays for G protein-coupled receptors
STAR Protocols, 2022 Summary: TRUPATH is a bioluminescence resonance energy transfer-based platform for quantifying G protein-coupled receptor activity via dissociation of heterotrimeric G protein biosensors.
Jeffrey F. DiBerto +3 more
doaj +1 more source
Vascular Biology, 2019 The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed +9 more
doaj +1 more source
CHIMIA, 2021 Nervous system disorders affect millions of people around the world, through a very broad range of diseases. Here we describe our contribution to find a treatment for patients suffering from three of those diseases.
Hasane Ratni
doaj +1 more source
Development of PCR based approach to detect potential mosaicism in porcine embryos
Journal of Animal Reproduction and Biotechnology, 2020 Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs.
Jongki Cho +5 more
doaj +1 more source