Results 31 to 40 of about 142,523 (351)
Latrophilin GPCR signaling mediates synapse formation
bioRxiv, 2021 Neural circuit assembly in the brain requires precise establishment of synaptic connections, but the mechanisms of synapse assembly remain incompletely understood.
Richard C. Sando, T. Südhof
semanticscholar +1 more source
Engineering GPCR signaling pathways with RASSLs
Nature Methods, 2008 Bruce R Conklin +2 more
exaly +3 more sources
Prediction and classification for GPCR sequences based on ligand specific features [PDF]
, 2006 Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them are orphan sequences (the activating ligand is unknown). Therefore,
F. Horn +8 more
core +1 more source
CHIMIA, 2021 Numerous members of the human G protein-coupled receptor (GPCR) superfamily are receptors of therapeutic interest. GPCRs are considered to be highly tractable for drug discovery, representing the targets of approximately one-third of currently licensed ...
Kalyan Bharati Akondi +2 more
doaj +1 more source
The role of structural dynamics in GPCR‐mediated signaling
The FEBS Journal, 2021 G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human physiology in response to a wide array of different extracellular stimuli and thus represent one of the largest groups of therapeutic drug targets.
D. Hilger
semanticscholar +1 more source
Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]
, 2018 More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian +7 more
core +1 more source
Event Timing in Associative Learning [PDF]
, 2012 Associative learning relies on event timing. Fruit flies for example, once trained with an odour that precedes electric shock, subsequently avoid this odour (punishment learning); if, on the other hand the odour follows the shock during training, it is ...
Herz, Andreas V. M. +3 more
core +1 more source
Arrestin-3 differentially regulates platelet GPCR subsets
Platelets, 2020 The principal demonstrated role of the nonvisual arrestins in vivo is to limit G protein-coupled receptor (GPCR) signaling. Nonetheless, a direct demonstration of this fundamental ability in platelets remains lacking, despite the prominent role played by
James L. Hutchinson +3 more
doaj +1 more source
Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]
, 2014 Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites.
Choi, Sun, Hyeon, Changbong, Lee, Yoonji
core +6 more sources
Development of PCR based approach to detect potential mosaicism in porcine embryos
Journal of Animal Reproduction and Biotechnology, 2020 Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs.
Jongki Cho +5 more
doaj +1 more source