Results 31 to 40 of about 113,722 (335)
Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. [PDF]
, 2017 The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling.
Adams, Christopher M. +12 more
core +2 more sources
The folding interactome of GPCRs [PDF]
BMC Pharmacology, 2011 Background The A2A adenosine receptor is a prototypical G proteincoupled receptor. It is expressed in a wide variety of cells including as different types as neurons, platelets, cells of the immune system and muscle. The A2A receptor has an unusually long C-terminus (of >120 residues), which for the most part is dispensable for coupling to Gs.
Michael Freissmuth +4 more
openaire +2 more sources
Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]
, 2018 More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian +7 more
core +1 more source
PRED-GPCR: GPCR recognition and family classification server [PDF]
Nucleic Acids Research, 2004 The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention. As the data flow rate from the various genome and proteome projects continues to grow, so does the need for fast, automated and
Stavros J. Hamodrakas +4 more
openaire +2 more sources
CHIMIA, 2021 Nervous system disorders affect millions of people around the world, through a very broad range of diseases. Here we describe our contribution to find a treatment for patients suffering from three of those diseases.
Hasane Ratni
doaj +1 more source
Prediction and classification for GPCR sequences based on ligand specific features [PDF]
, 2006 Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them are orphan sequences (the activating ligand is unknown). Therefore,
F. Horn +8 more
core +1 more source
Orphan GPCRs and Neuromodulation [PDF]
Neuron, 2012 Most G protein-coupled receptors (GPCRs) started as orphan GPCRs. Matching them to known neuromodulators led to the elucidation of the broad diversity of the neuroreceptor families. Moreover, orphan GPCRs have also been used as targets to discover novel neuromodulators.
openaire +3 more sources
Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms [PDF]
Open Biology, 2016 Odorant receptors (ORs) control several aspects of cell fate in olfactory sensory neurons (OSNs), including singular gene choice and axonal identity.
Kiavash Movahedi +2 more
doaj +1 more source
Arrestin-3 differentially regulates platelet GPCR subsets
Platelets, 2020 The principal demonstrated role of the nonvisual arrestins in vivo is to limit G protein-coupled receptor (GPCR) signaling. Nonetheless, a direct demonstration of this fundamental ability in platelets remains lacking, despite the prominent role played by
James L. Hutchinson +3 more
doaj +1 more source
Development of PCR based approach to detect potential mosaicism in porcine embryos
Journal of Animal Reproduction and Biotechnology, 2020 Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs.
Jongki Cho +5 more
doaj +1 more source