Results 41 to 50 of about 61,419 (246)
Biophysics and PhysicobiologyStructural fluctuations and dynamic cross-correlations in the mouse eugenol olfactory receptor (Olfr73) were studied by molecular dynamics (MD) simulation to characterize the dynamic response of the protein upon ligand binding.
Chisato Okamoto, Koji Ando
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Ontogeny of the specificity of gonadotropin receptors and gene expression in carp
Endocrine Connections, 2019 The pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are the principle endocrine drivers of reproductive processes in the gonads of jawed vertebrates.
Lian Hollander-Cohen +3 more
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Advanced Science, EarlyView.In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu +11 more
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Brain Sciences, 2019 The molecular pathways underlying the induction and maintenance of long-term synaptic plasticity have been extensively investigated revealing various mechanisms by which neurons control their synaptic strength.
Amjad H. Bazzari, H. Rheinallt Parri
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Sugar‐sensing swodkoreceptors and swodkocrine signaling
Animal Models and Experimental Medicine, EarlyView.Sugar‐sensing swodkoreceptors that trigger swodkocrine signaling. Abstract Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules. To study sugar signaling at the systemic level, there is an urgent need to systematically identify sugar‐sensing ...
Savani Anbalagan
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Structures and functions of cilia during vertebrate embryo development
Molecular Reproduction and Development, Volume 89, Issue 12, Page 579-596, December 2022., 2022 Abstract Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells have an immotile primary cilium that mediates cell signaling, and some specialized cells assemble one or multiple cilia that are motile and beat synchronously to move fluids in one direction.
Jeffrey D. Amack
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Frontiers in Immunology, 2020 Expressions of G protein-coupled receptors (GPCR) on immune and tissue resident cells are the consequence of the cellular environment, which is highly variable.
Gabriela Riemekasten +7 more
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Inhibition of signaling downstream of beta‐2 adrenoceptor by propranolol in prostate cancer cells
The Prostate, Volume 83, Issue 3, Page 237-245, February 15, 2023., 2023 Abstract Background There is accumulating evidence that propranolol, an antagonist of beta‐1 and beta‐2 adrenoreceptors, extends survival of patients with prostate cancer; yet it is not known whether propranolol inhibits beta‐adrenergic signaling in prostate cancer cells, or systemic effects of propranolol play the leading role in slowing down cancer ...
Aljoharah Alaskar +7 more
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Dampening of neurotransmitter action: molecular similarity within the melatonin structure
Endocrine Regulations, 2018 Objectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides.
Williams Wynford R.
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Nature Communications, 2022 GPCR kinases (GRKs) regulate GPCR interactions and thus functions. Here, the authors report a comprehensive panel of GRK knockout cells, used to assess the GRK-specific β-arrestin recruitment. Selective engagement of GRKs induces distinct GPCR–β-arrestin
J. Drube +15 more
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