Results 41 to 50 of about 119,228 (259)
Functional selectivity of GPCR-directed drug action through location bias. [PDF]
, 2017 G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco +6 more
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Vascular Biology, 2019 The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed +9 more
doaj +1 more source
CHIMIA, 2021 Nervous system disorders affect millions of people around the world, through a very broad range of diseases. Here we describe our contribution to find a treatment for patients suffering from three of those diseases.
Hasane Ratni
doaj +1 more source
Development of PCR based approach to detect potential mosaicism in porcine embryos
Journal of Animal Reproduction and Biotechnology, 2020 Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs.
Jongki Cho +5 more
doaj +1 more source
Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
Current Research in Pharmacology and Drug Discovery, 2022 GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse proteins to form ...
Haifeng Eishingdrelo +4 more
doaj +1 more source
British Journal of Pharmacology, 2009 This themed section of BJP includes 11 reviews on the biology of G‐protein coupled receptors (GPCRs) and the drug targets that these present, 21 research papers on the pharmacology of a range of GPCRs and Commentaries on four of the papers.Areas reviewed include molecular interactions, particular in respect of hetero‐dimerisation between receptors and ...
G, Milligan, J C, McGrath
openaire +2 more sources
Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms [PDF]
Open Biology, 2016 Odorant receptors (ORs) control several aspects of cell fate in olfactory sensory neurons (OSNs), including singular gene choice and axonal identity.
Kiavash Movahedi +2 more
doaj +1 more source
Genetically encoded fluorescent biosensors for GPCR research
Frontiers in Cell and Developmental Biology, 2022 G protein-coupled receptors (GPCRs) regulate a wide range of physiological and pathophysiological cellular processes, thus it is important to understand how GPCRs are activated and function in various cellular contexts.
Hyunbin Kim +6 more
doaj +1 more source
Acta Pharmacologica Sinica, 2012 G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human genome, play a crucial role in multiple physiological functions as well as in tumor growth and metastasis. For instance, various molecules like hormones, lipids, peptides and neurotransmitters exert their biological effects by binding to these seven-transmembrane ...
Lappano R, MAGGIOLINI, Marcello
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Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]
, 2010 To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
core +2 more sources