Results 41 to 50 of about 92,178 (306)
British Journal of Pharmacology, 2009 This themed section of BJP includes 11 reviews on the biology of G‐protein coupled receptors (GPCRs) and the drug targets that these present, 21 research papers on the pharmacology of a range of GPCRs and Commentaries on four of the papers.Areas reviewed include molecular interactions, particular in respect of hetero‐dimerisation between receptors and ...
G, Milligan, J C, McGrath
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Latrophilin GPCR signaling mediates synapse formation
bioRxiv, 2021 Neural circuit assembly in the brain requires precise establishment of synaptic connections, but the mechanisms of synapse assembly remain incompletely understood.
Richard C. Sando, T. Südhof
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Agonist and antagonist TRUPATH assays for G protein-coupled receptors
STAR Protocols, 2022 Summary: TRUPATH is a bioluminescence resonance energy transfer-based platform for quantifying G protein-coupled receptor activity via dissociation of heterotrimeric G protein biosensors.
Jeffrey F. DiBerto +3 more
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Acta Pharmacologica Sinica, 2012 G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human genome, play a crucial role in multiple physiological functions as well as in tumor growth and metastasis. For instance, various molecules like hormones, lipids, peptides and neurotransmitters exert their biological effects by binding to these seven-transmembrane ...
Lappano R, MAGGIOLINI, Marcello
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Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms [PDF]
Open Biology, 2016 Odorant receptors (ORs) control several aspects of cell fate in olfactory sensory neurons (OSNs), including singular gene choice and axonal identity.
Kiavash Movahedi +2 more
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Receptor-Arrestin Interactions: The GPCR Perspective
Biomolecules, 2021 Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins ...
M. Seyedabadi +3 more
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Genetically encoded fluorescent biosensors for GPCR research
Frontiers in Cell and Developmental Biology, 2022 G protein-coupled receptors (GPCRs) regulate a wide range of physiological and pathophysiological cellular processes, thus it is important to understand how GPCRs are activated and function in various cellular contexts.
Hyunbin Kim +6 more
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The role of structural dynamics in GPCR‐mediated signaling
The FEBS Journal, 2021 G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human physiology in response to a wide array of different extracellular stimuli and thus represent one of the largest groups of therapeutic drug targets.
D. Hilger
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A Web Server for GPCR-GPCR Interaction Pair Prediction
Frontiers in Endocrinology, 2022 The GGIP web server (https://protein.b.dendai.ac.jp/GGIP/) provides a web application for GPCR-GPCR interaction pair prediction by a support vector machine. The server accepts two sequences in the FASTA format. It responds with a prediction that the input GPCR sequence pair either interacts or not.
Wataru Nemoto +7 more
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Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs
Nature Structural & Molecular Biology, 2020 G-protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and the targets of over 30% of currently marketed pharmaceuticals.
Meng Zhang +14 more
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