Results 51 to 60 of about 61,419 (246)

Comparison of allosteric signaling in DnaK and BiP using mutual information between simulated residue conformations

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 2, Page 237-255, February 2023., 2023
Abstract The heat shock protein 70 kDa (Hsp70) chaperone system serves as a critical component of protein quality control across a wide range of prokaryotic and eukaryotic organisms. Divergent evolution and specialization to particular organelles have produced numerous Hsp70 variants which share similarities in structure and general function, but ...
Markus Schneider, Iris Antes
wiley   +1 more source

Deep hierarchical embedding for simultaneous modeling of GPCR proteins in a unified metric space

Scientific Reports, 2021
GPCR proteins belong to diverse families of proteins that are defined at multiple hierarchical levels. Inspecting relationships between GPCR proteins on the hierarchical structure is important, since characteristics of the protein can be inferred from ...
Taeheon Lee, Sangseon Lee, Minji Kang, Sun Kim   +3 more
doaj   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Identifying GPCR-drug interaction based on wordbook learning from sequences

BMC Bioinformatics, 2020
Background G protein-coupled receptors (GPCRs) mediate a variety of important physiological functions, are closely related to many diseases, and constitute the most important target family of modern drugs.
Pu Wang, Xiaotong Huang, Wangren Qiu, Xuan Xiao   +3 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases

Acta Materia Medica
G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs crosstalk with several transducers, including heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. GPCR-
Shengnan Shen, Qiwen Liao, Liwei Gu, Yongping Zhu, Yanqing Liu, Xinwei Zhang, Junzhe Zhang, Qiaoli Shi, Yuxiang Sun, Jigang Wang, Ligen Lin   +10 more
doaj   +1 more source

Evaluation of Polar Substituted Schiff Bases and 1,2,3‐Triazole Hybrids as Anticancer Agents

Chemistry &Biodiversity, EarlyView.
ABSTRACT Polar substituted Schiff bases and 1,2,3‐triazole hybrids (2–6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single ...
Yonas Belay, Alfred Muller, Sage Singh, Adedapo S. Adeyinka, Lesetja R. Motadi, Abel K. Oyebamiji   +5 more
wiley   +1 more source

Characterization and molecular identification of the lumpy skin disease virus in cattle in the Mekong Delta of Vietnam

Open Veterinary Journal
Background: Lumpy skin disease (LSD) is caused by a virus belonging to the genus Capripoxvirus, exhibiting clinical symptoms ranging from mild signs to the development of nodules.
Tran Ngoc Bich, Le Quang Trung, Truong Van Hieu, Vo Tuan Khai Huyen, Thai Quoc Hieu, Huynh Truong Giang, Nguyen Tran Phuoc Chien   +6 more
doaj   +1 more source

TBXA2R gene variants associated with bleeding

Platelets, 2018
Platelet activity is regulated by a number of surface expressed G protein-coupled receptors (GPCRs) including the α isoform of the thromboxane receptor (TPα receptor). With the advance of genomic technologies, there has been a substantial increase in the
Stuart James Mundell, Andrew Mumford
doaj   +1 more source

Targeting Gi/o protein–coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy

JCI Insight, 2021
GPCRs are highly desirable drug targets for human disease. Although GPCR dysfunction drives development and progression of many tumors, including breast cancer (BC), targeting individual GPCRs has limited efficacy as a cancer therapy because numerous ...
Cancan Lyu, Yuanchao Ye, Maddison M. Lensing, Kay-Uwe Wagner, Ronald J. Weigel, Songhai Chen   +5 more
doaj   +1 more source