Results 61 to 70 of about 67,843 (252)
Advanced Science, EarlyView.A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu +27 more
wiley +1 more source
Structure and function of GPCRs
, 2019 Los receptores acoplados a proteínas G (GPCRs) son la superfamilia más grande y diversa de proteínas transmembrana en Eucariotas. Estos receptores transducen una gran variedad de señales exógenas y endógenas como fotones, hormonas o neurotransmisores ...
Jiménez Rosés, Mireia
core +2 more sources
GPCRs in autocrine and paracrine regulations
, 2019 G protein-coupled receptors (GPCRs) constitute the largest superfamily of integral membrane protein receptors. As signal detectors, the several 100 known GPCRs are responsible for sensing the plethora of endogenous ligands that are critical for the ...
Tse, Lap Hang, Wong, Yung Hou
core +1 more source
Advanced Science, EarlyView.Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami +7 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han +11 more
wiley +1 more source
Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition
Advanced Science, EarlyView.CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu +13 more
wiley +1 more source
Ciliary Membrane Lipid Homeostasis in Health and Disease
Advanced Science, EarlyView.This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang +3 more
wiley +1 more source
Somatic nonsilent mutations of GPCRs.
, 2019 (A) Frequency of GPCR mutations in the TCGA cohort (n = 5,103). Inset: 20 most frequently mutated GPCRs. (B) The average number of all genes (red) and GPCRs (blue) with somatic, nonsilent mutations per tumor genome for the TCGA tumor types surveyed.
Krishna Sriram (5073854) +4 more
core +1 more source
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
Expression pattern analysis of all detected GPCRs.
, 2013 A The bar diagram shows the number of detected GPCRs that had FPKM values higher than 1 for the liver (L), skeletal muscle (SM), olfactory epithelium (OE), dorsal root ganglia (DRG), brain (B), and trigeminal ganglia (TG).
Janine Altmüller (120887) +10 more
core +1 more source