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Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms. [PDF]

open access: yesInt J Mol Sci
Saldaña R   +5 more
europepmc   +1 more source
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Identification of GPR55 as a lysophosphatidylinositol receptor

Biochemical and Biophysical Research Communications, 2007
GPR55 is an orphan G protein-coupled receptor. In this study, we explored a possible endogenous ligand for GPR55 using HEK293 cells which expressed GPR55. We found that lysophosphatidylinositol induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably GPR55-expressing cells.
Atsushi Yamashita   +2 more
exaly   +3 more sources

Advances Towards The Discovery of GPR55 Ligands

Current Medicinal Chemistry, 2016
The G-protein-coupled receptor 55 (GPR55) was identified in 1999. It was proposed as a novel member of the endocannabinoid system due to the fact that some endogenous, plant-derived and synthetic cannabinoid ligands act on GPR55. However, the complexity of the cellular downstream signaling pathways related to GPR55 activation delayed the discovery of ...
Paula Morales, Nadine Jagerovic
exaly   +4 more sources

GPR55 in the brain and chronic neuropathic pain

Behavioural Brain Research, 2021
There is a clear need for novel and improved therapeutic strategies for alleviating chronic neuropathic pain, as well as a need for better understanding of brain mechanisms of neuropathic pain, which are less understood than spinal and peripheral mechanisms.
Sabiha, Armin   +3 more
openaire   +2 more sources

The orphan receptor GPR55 is a novel cannabinoid receptor [PDF]

open access: yesBritish Journal of Pharmacology, 2007
Background:The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors. Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes.Experimental ...
Stephan Hjorth
exaly   +3 more sources

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