Ion channels and G protein-coupled receptors: Cannabidiol actions on disorders of excitability and synaptic excitatory-inhibitory ratio. [PDF]
Tsien RW, Rosenberg EC.
europepmc +1 more source
Special Issue "Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 3rd Edition". [PDF]
Zhou Z, Kihara AH.
europepmc +1 more source
Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms. [PDF]
Saldaña R +5 more
europepmc +1 more source
Endocannabinoid system upregulates the enrichment and differentiation of human iPSC- derived spermatogonial stem cells via CB2R agonism. [PDF]
Gizer M +6 more
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Effects of Cannabidiol on Bone Health: A Comprehensive Scoping Review. [PDF]
Shakir SA, Chin KY.
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Identification of GPR55 as a lysophosphatidylinositol receptor
Biochemical and Biophysical Research Communications, 2007GPR55 is an orphan G protein-coupled receptor. In this study, we explored a possible endogenous ligand for GPR55 using HEK293 cells which expressed GPR55. We found that lysophosphatidylinositol induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably GPR55-expressing cells.
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Advances Towards The Discovery of GPR55 Ligands
Current Medicinal Chemistry, 2016The G-protein-coupled receptor 55 (GPR55) was identified in 1999. It was proposed as a novel member of the endocannabinoid system due to the fact that some endogenous, plant-derived and synthetic cannabinoid ligands act on GPR55. However, the complexity of the cellular downstream signaling pathways related to GPR55 activation delayed the discovery of ...
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GPR55 in the brain and chronic neuropathic pain
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Background:The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors. Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes.Experimental ...
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