Results 131 to 140 of about 3,347 (166)
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GPR55 and the regulation of glucose homeostasis
The International Journal of Biochemistry & Cell Biology, 2017Pathophysiological conditions such as obesity and type 2 diabetes (T2D) are reportedly associated to over-activation of the endocannabinoid system (ECS). Therefore, modulation of the ECS offers potential therapeutic benefits on those diseases. GPR55, the receptor for L-α-lysophosphatidylinositol (LPI) that has also affinity for various cannabinoid ...
Eva, Tudurí +4 more
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Advances in the Physiology of GPR55 in the Central Nervous System [PDF]
Current Neuropharmacology, 2017 The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucidated.A bibliographic search in PubMed ...
Mónica Mendez-Diaz +2 more
exaly +3 more sources
2018
G protein-coupled receptor 55 (GPR55) was first cloned in 1999 and is a 319 amino acid seven transmembrane G protein-coupled receptor (GPCR) that is mapped to chromosome 2q37 (human) (Sawzdargo et al. 1999). It displays features common with other Family A GPCRs including a short extracellular N-terminal and C-terminal tail and contains two highly ...
A. C. Simcocks +5 more
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G protein-coupled receptor 55 (GPR55) was first cloned in 1999 and is a 319 amino acid seven transmembrane G protein-coupled receptor (GPCR) that is mapped to chromosome 2q37 (human) (Sawzdargo et al. 1999). It displays features common with other Family A GPCRs including a short extracellular N-terminal and C-terminal tail and contains two highly ...
A. C. Simcocks +5 more
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Is GPR55 an anandamide receptor?
Vitamins and hormones, 2009Anandamide activates CB(1) cannabinoid receptors but also has effects, particularly in the vasculature, that cannot be explained by actions at either this or the other cloned cannabinoid receptor, the CB(2) receptor. These effects are probably mediated by a novel G protein-coupled receptor, but genome searching has not revealed a strong candidate ...
Andrew J, Brown, C, Robin Hiley
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2012
The identification of GPR55 as a possible cannabinoid receptor generated a flurry of interest as based on the hope that this receptor might explain some of the non-CB1/CB2/TRPV1 effects of cannabinoid compounds. However, it rapidly became clear that the pharmacology and signaling of GPR55 were quite complicated.
Hui-Chen Lu +3 more
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The identification of GPR55 as a possible cannabinoid receptor generated a flurry of interest as based on the hope that this receptor might explain some of the non-CB1/CB2/TRPV1 effects of cannabinoid compounds. However, it rapidly became clear that the pharmacology and signaling of GPR55 were quite complicated.
Hui-Chen Lu +3 more
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GPR55: From orphan to metabolic regulator?
Pharmacology & Therapeutics, 2015GPR55 belongs to the class A family of G-protein coupled receptor (GPCRs) and its activity is regulated by a range of synthetic and endogenous cannabinoids, and by lipid-derived ligands. Cannabinoids are known to be important in controlling appetite and metabolic balance, and it is now emerging that GPR55 may have a role to play in energy homeostasis ...
Shanta Persaud, Bo Liu, Peter Jones
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GPR55, a Lysophosphatidylinositol Receptor with Cannabinoid Sensitivity?
Current Topics in Medicinal Chemistry, 2010Emerging data indicates the existence of novel molecular targets for cannabinoid ligands and recently it has been suggested that the orphan G-protein coupled receptor, GPR55 can be activated by a range of endogenous, plant and synthetic cannabinoids.
Nevalainen, Tapio, Irving, Andrew J.
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Pharmacological characterization of GPR55, a putative cannabinoid receptor [PDF]
Pharmacology & Therapeutics, 2010 GPR55 has recently attracted much attention as another member of the cannabinoid family, potentially explaining physiological effects that are non-CB1/CB2 mediated. However, the data gathered so far are conflicting with respect to its pharmacology. We review the primary literature to date on GPR55, describing its discovery, structure, pharmacology and ...
Mary Abood, Haleli Sharir
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The enigmatic pharmacology of GPR55
Trends in Pharmacological Sciences, 2009Preliminary data presented at conferences and in the patent literature introduced the possibility the orphan receptor GPR55 might account for some of the well-documented non-CB(1), non-CB(2) effects reported for certain cannabinoid ligands. Several peer-reviewed publications have recently emerged in which the pharmacology of the cannabinoids at GPR55 ...
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Role of the lysophosphatidylinositol/GPR55 axis in cancer
Advances in Biological Regulation, 2016Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI.
Falasca M, Ferro R
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