Results 141 to 150 of about 3,347 (166)
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2012
Evidence accumulated during the last few years suggests that GPR55 is an important component of the molecular circuitry that controls cancer cell behavior. As will be described in this chapter, this receptor has been directly or indirectly related to the basic alterations that drive malignant growth: uncontrolled cancer cell proliferation, sustained ...
Clara Andradas +4 more
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Evidence accumulated during the last few years suggests that GPR55 is an important component of the molecular circuitry that controls cancer cell behavior. As will be described in this chapter, this receptor has been directly or indirectly related to the basic alterations that drive malignant growth: uncontrolled cancer cell proliferation, sustained ...
Clara Andradas +4 more
openaire +1 more source
GPR55: A therapeutic target for Parkinson's disease?
Neuropharmacology, 2017The GPR55 receptor is expressed abundantly in the brain, especially in the striatum, suggesting it might fulfill a role in motor function. Indeed, motor behavior is impaired in mice lacking GPR55, which also display dampened inflammatory responses. Abnormal-cannabidiol (Abn-CBD), a synthetic cannabidiol (CBD) isomer, is a GPR55 agonist that may serve ...
Maria S Aymerich +2 more
exaly +3 more sources
A Functional Assay for GPR55: Envision Protocol
2016AlphaScreen(®) SureFire(®) assay is a novel technology that combines luminescent oxygen channeling technology, nano-beads, and monocloncal antibodies to detect the level of a selected protein in a volume lower than 5 μl. This method is more sensitive compared with the traditional enzyme-linked immunosorbent assays (ELISA), and can detect an increasing ...
Sharon, Anavi-Goffer, Ruth A, Ross
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The actions and metabolism of lysophosphatidylinositol, an endogenous agonist for GPR55
Prostaglandins & Other Lipid Mediators, 2013Lysophosphatidylinositol (LPI) is a subspecies of lysophospholipid and is assumed to be not only a degradation product of phosphatidylinositol (PI), but also a bioactive lysophospholipid mediator. However, not much attention has been directed toward LPI compared to lysophosphatidic acid (LPA), since the receptor for LPI has not been identified.
Atsushi, Yamashita +5 more
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GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors
Life Sciences, 2013This review presents a summary of what is known about the G-protein coupled receptors GPR35 and GPR55 and their potential characterization as lysophospholipid or cannabinoid receptors, respectively. Both GPR35 and GPR55 have been implicated as important targets in pain and cancer, and additional diseases as well.
Mary Abood, Pingwei Zhao
exaly +3 more sources
The Role of GPR55 in Bone Biology
2012A novel and necessary role for GPR55 in bone physiology was demonstrated by Whyte et al. (Proc Natl Acad Sci 106(38):16551–16516, 2009). This chapter aims to summarise the work that became the first study to demonstrate a non-neuronal physiological role for GPR55 in vivo.
Lauren S. Whyte, Ruth A. Ross
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Structure-Activity Relationship of the GPR55 Antagonist, CID16020046
Pharmacology, 2018<b><i>Background/Aims:</i></b> CID16020046 blocks the effect of the lipid lysophosphatidylinositol (LPI) at its receptor, GPR55. CID16020046 and another antagonist, ML193, have been used to investigate GPR55-mediated effects of LPI on cells, tissues, and in vivo.
Andrew J. Brown +4 more
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The Journal of Pharmacology and Experimental Therapeutics, 2011
GPR55 is a G protein-coupled receptor activated by L-α-lysophosphatidylinositol and suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular endothelial cells. It has affinity for certain cannabinoids (molecules that interact with the cannabinoid CB(1) and CB(2) receptors), but investigation of its functional role in cell-
Andrew J, Brown +10 more
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GPR55 is a G protein-coupled receptor activated by L-α-lysophosphatidylinositol and suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular endothelial cells. It has affinity for certain cannabinoids (molecules that interact with the cannabinoid CB(1) and CB(2) receptors), but investigation of its functional role in cell-
Andrew J, Brown +10 more
openaire +2 more sources
A potential role for GPR55 in the regulation of energy homeostasis
Drug Discovery Today, 2014G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is expressed in several tissues involved in regulating energy homeostasis, including the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and skeletal muscle.
Simcocks, Anna C +5 more
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Exploring the thienopyrimidine scaffold for GPR55
2021GPR55 is an orphan Class A G-protein coupled receptor that recognizes a sub-set of cannabinoid CB1 and CB2 ligands, suggesting that GPR55 could belong to the endocannabinoid system. Lysophosphatidylinositol (LPI) has been proposed to be endogenous ligand for GPR55.
Figuerola-Asencio, Laura +6 more
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