Results 91 to 100 of about 8,801 (259)

Functional significance of the platelet immune receptors GPVI and CLEC-2.

Journal of Clinical Investigation, 2019
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin ...
J. Rayes, S. Watson, B. Nieswandt
semanticscholar   +1 more source

Acquired platelet GPVI receptor dysfunction in critically-ill patients with sepsis.

Blood, 2021
GPVI, the platelet immunoreceptor tyrosine activating motif (ITAM) receptor for collagen plays a striking role on vascular integrity in animal models of inflammation and sepsis.
L. Weiss, G. Manukjan, A. Pflug, Nadine Winter, M. Weigel, Nils Nagler, M. Kredel, Thiên-Trí Lâm, B. Nieswandt, D. Weismann, H. Schulze   +10 more
semanticscholar   +1 more source

Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels [PDF]

, 2014
Chemokine-induced stem cell recruitment is a promising strategy for post myocardial infarction treatment. Injection of stromal cell-derived factor 1 (SDF1) has been shown to attract bone marrow-derived progenitor cells (BMPCs) from the blood that have ...
Bindermann, Andrea H., Eble, Johannes A., Freund, Désirée, Gawaz, Meinrad P., Hinderer, Svenja, Monaghan, Michael, Schenke-Layland, Katja, Schesny, Marianne K., Seifert, Martina, Vogel, Sebastian   +9 more
core   +1 more source

GPVI and CLEC‐2 in hemostasis and vascular integrity [PDF]

Journal of Thrombosis and Haemostasis, 2010
The glycoprotein VI (GPVI)-FcR gamma-chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin through an immunoreceptor tyrosine-based activation motif (ITAM)-regulated signaling pathway. ITAMs are characterized by two YxxL sequences separated by 6-12 amino acids and are found associated with ...
Steve P. Watson, John Herbert, Alice Y. Pollitt   +2 more
openaire   +3 more sources

Fibrin activates GPVI in human and mouse platelets [PDF]

Blood, 2015
Key PointsFibrin is a novel ligand for the platelet collagen receptor, GPVI, increasing platelet procoagulant activity. Activation of GPVI by fibrin contributes to thrombus growth and stabilization.
Jonathan Frampton, Markus Bender, Craig E. Hughes, Stephanie Watson, Steve P. Watson, Osama Alshehri, Samantha J. Montague   +6 more
openaire   +2 more sources

Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans

Clinical Pharmacology &Therapeutics, EarlyView.
Clopidogrel, an anti‐platelet drug, is used to prevent thrombosis after percutaneous coronary intervention. Clopidogrel resistance results in recurring ischemic events, with African Americans (AA) suffering disproportionately. The aim of this study was to discover novel biomarkers of clopidogrel resistance in African Americans using genome and ...
Guang Yang, Cristina Alarcon, Catherine Chanfreau, Norman H. Lee, Paula Friedman, Edith Nutescu, Matthew Tuck, Travis O'Brien, Li Gong, Teri E. Klein, Kyong‐Mi Chang, Philip S. Tsao, David O. Meltzer, Julie A. Lynch, Million Veteran Program, Sony Tuteja, Minoli A. Perera   +16 more
wiley   +1 more source

Platelet glycoprotein VI genetic quantitative and qualitative defects

Platelets, 2019
Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for ...
Martine Jandrot-Perrus, Cedric Hermans, Diego Mezzano   +2 more
doaj   +1 more source

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability

Research and Practice in Thrombosis and Haemostasis, 2021
Background The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforces platelet ...
Muhammad Usman Ahmed, Nicolas Receveur, Emily Janus‐Bell, Clarisse Mouriaux, Christian Gachet, Martine Jandrot‐Perrus, Béatrice Hechler, Elizabeth E. Gardiner, Pierre H. Mangin   +8 more
doaj   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, EarlyView.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source

GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion

Platelets, 2017
Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation ...
Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Fatemeh Nassaji, Zeynab Pirmohammad Jamaat   +3 more
doaj   +1 more source