Results 91 to 100 of about 6,202 (185)

Immuno‐haemostatic dysregulation in heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 5, Page 3444-3460, October 2025.
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a complex condition with partially unclear pathophysiology, in which systemic inflammation is a central contributor to changes in cardiac structure and function. The contribution of non‐traditional immune effectors—such as platelets and coagulation—remains underexplored in HFpEF ...
Giorgia D'Italia, Daniëlle M. Coenen, Titus P. Lemmens, Lloyd Brandts, Simone J. H. Wielders, Magdolna Nagy, Sanne G. J. Mourmans, Anouk Achten, Ahmad Al‐Abadi, Jerremy Weerts, Arantxa Barandiaran Aizpurua, Vanessa van Empel, Blanche Schroen, Judith M. E. M. Cosemans   +13 more
wiley   +1 more source

Insights into the clinical, platelet and genetic landscape of inherited thrombocytopenia with malignancy risk

British Journal of Haematology, Volume 207, Issue 4, Page 1565-1577, October 2025.
Inherited thrombocytopenia (IT) caused by germline variants in RUNX1, ETV6 or ANKRD26 carries a high risk of developing haematological malignancy. This study examined the clinical, platelet and molecular characteristics of 66 patients with these conditions, who carried 24 distinct genetic variants in the corresponding genes.
Ana Marín‐Quílez, Ana Sánchez‐Fuentes, Ana Zamora‐Cánovas, Pedro Luis Gómez‐González, Lorena Diaz‐Ajenjo, Rocío Benito, Agustín Rodríguez‐Alén, Teresa Sevivas, Thais Murciano, Laura Murillo, Nora V. Butta, Nuria Revilla, Rosa Campos, Paola Escribano, Jordi Esteve, Nuria Fernández‐Mosteirin, Francisca Ferrer‐Marín, Laura Hernández, Jorge Huerta‐Aragonés, Antonio León, Mónica López‐Duarte, Eugenia López, Mónica Martín‐Salces, Meritxell Nomdedeu, Raquel Oña, Irene Peláez‐Pleguezuelos, Fernando Ramos, Elena Sebastián, Claudia Serrano, Cristina Sierra‐Aisa, Rosa Vidal‐Laso, José Ramón González‐Porras, María Luisa Lozano, José María Bastida, José Rivera   +34 more
wiley   +1 more source

Sex‐specific predictive value of reticulated platelets in coronary artery disease: A systematic review and meta‐analysis

European Journal of Clinical Investigation, Volume 55, Issue 10, October 2025.
This meta‐analysis of 1835 patients (527 females, 1308 males) shows that elevated RPs are significant predictors of MACCE in both sexes (males: OR 1.99, 95% CI 1.3–3.05; females: OR 2.29, 95% CI 1.31–3.99). Elevated RPs are more strongly associated with cardiovascular death in females (OR 3.29, 95% CI 1.69–6.40) compared to males (OR 2.19, 95% CI .98–4.
Sebastien Elvinger, Stephanie G. Kuehne, Andrea Patrignani, Maximilian Tscharre, Matthias Freynhofer, Leor Perl, Ran Kornowski, Francesca Cesari, Rossella Marcucci, Laura Novelli, Isabell Bernlochner, Philip W. Raake, Mauro Chiarito, Dario Bongiovanni   +13 more
wiley   +1 more source

The effects of signal transducer and activator of transcription three mutations on human platelets

Platelets, 2018
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva, Frank L. van de Veerdonk, Yang Li, Rahajeng N. Tunjungputri, Sami Simons, Philip G. De Groot, Mihai M. Netea, Yvonne F. Heijdra, Quirijn de Mast, André J.A.M. van der Ven   +9 more
doaj   +1 more source

Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Platelets, 2020
Soluble forms of the low-affinity immunoglobulin receptor FcγRIIa (sFcγRIIa) lacking the cytoplasmic tail have been reported in plasma however the mechanism and functional consequences are unknown.
Jianlin Qiao, Eimear Dunne, Bruce Wines, Dermot Kenny, Geraldine M. McCarthy, P. Mark Hogarth, Kailin Xu, Robert K. Andrews, Elizabeth E. Gardiner   +8 more
doaj   +1 more source

A Critical Review on BH3 Mimetic Drugs and the Treatment of Cancer‐Associated Thrombosis (CAT): A Proposed Design for a Drug Delivery System Capable of Simultaneously Targeting Tumor Cells and Activated Platelets

Cancer Medicine, Volume 14, Issue 18, September 2025.
Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh, Nazanin Heidari, Jalal Naghinezhad, Alireza Ghasemzadeh, Ehteramolsadat Hosseini   +4 more
wiley   +1 more source

G6f-like is an ITAM-containing collagen receptor in thrombocytes.

PLoS ONE, 2012
Collagen activates mammalian platelets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor γ-chain, which has an immunoreceptor tyrosine-based activation motif (ITAM).
Craig E Hughes, Uvaraj P Radhakrishnan, Marie Lordkipanidzé, Stuart Egginton, Johannes M Dijkstra, Pudur Jagadeeswaran, Stephen P Watson   +6 more
doaj   +1 more source

Should aspirin be replaced with ADP blockers and anti-GPVI to manage thrombosis? [PDF]

, 2022
Hafsa Khan, Tahira Ghulam, Naseer Ahmed, Muhammad Rafai Babar, Simon D. J. Calaminus, Muhammad Zuhair Yusuf   +5 more
openalex   +1 more source

Regulation of platelet membrane protein shedding in health and disease

Platelets, 2017
Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ...
Amanda E. Au, Emma C. Josefsson
doaj   +1 more source

mTOR regulates GPVI-mediated platelet activation [PDF]

, 2021
Longsheng Wang, Gang Liu, Nannan Wu, Baiyun Dai, Shuang Han, Qiaoyun Liu, Fang Huang, Zhihua Chen, Weihong Xu, Dajing Xia, Cunji Gao   +10 more
openalex   +1 more source