Results 91 to 100 of about 8,521 (239)

Immuno‐haemostatic dysregulation in heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 5, Page 3444-3460, October 2025.
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a complex condition with partially unclear pathophysiology, in which systemic inflammation is a central contributor to changes in cardiac structure and function. The contribution of non‐traditional immune effectors—such as platelets and coagulation—remains underexplored in HFpEF ...
Giorgia D'Italia, Daniëlle M. Coenen, Titus P. Lemmens, Lloyd Brandts, Simone J. H. Wielders, Magdolna Nagy, Sanne G. J. Mourmans, Anouk Achten, Ahmad Al‐Abadi, Jerremy Weerts, Arantxa Barandiaran Aizpurua, Vanessa van Empel, Blanche Schroen, Judith M. E. M. Cosemans   +13 more
wiley   +1 more source

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

Platelets, 2021
GPVI and CLEC-2 have emerged as promising targets for long-term prevention of both arterial thrombosis and thrombo-inflammation with a decreased bleeding risk relative to current drugs.
Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam, Steve P. Watson   +4 more
doaj   +1 more source

PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and platelet function through upregulation of protein kinase A activity [PDF]

, 2017
BACKGROUND: Agonists for the peroxisome proliferator activated receptor PPARγ, have been shown to have inhibitory effects on platelet activity following stimulation by GPVI and GPCR agonists.
Bye, A. P., Flora, G. D., Gibbins, J. M., Kriek, N., Naran, K., Sage, T., Unsworth, A. J.   +6 more
core   +1 more source

Insights into the clinical, platelet and genetic landscape of inherited thrombocytopenia with malignancy risk

British Journal of Haematology, Volume 207, Issue 4, Page 1565-1577, October 2025.
Inherited thrombocytopenia (IT) caused by germline variants in RUNX1, ETV6 or ANKRD26 carries a high risk of developing haematological malignancy. This study examined the clinical, platelet and molecular characteristics of 66 patients with these conditions, who carried 24 distinct genetic variants in the corresponding genes.
Ana Marín‐Quílez, Ana Sánchez‐Fuentes, Ana Zamora‐Cánovas, Pedro Luis Gómez‐González, Lorena Diaz‐Ajenjo, Rocío Benito, Agustín Rodríguez‐Alén, Teresa Sevivas, Thais Murciano, Laura Murillo, Nora V. Butta, Nuria Revilla, Rosa Campos, Paola Escribano, Jordi Esteve, Nuria Fernández‐Mosteirin, Francisca Ferrer‐Marín, Laura Hernández, Jorge Huerta‐Aragonés, Antonio León, Mónica López‐Duarte, Eugenia López, Mónica Martín‐Salces, Meritxell Nomdedeu, Raquel Oña, Irene Peláez‐Pleguezuelos, Fernando Ramos, Elena Sebastián, Claudia Serrano, Cristina Sierra‐Aisa, Rosa Vidal‐Laso, José Ramón González‐Porras, María Luisa Lozano, José María Bastida, José Rivera   +34 more
wiley   +1 more source

Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool

Platelets, 2017
Platelet membrane bedecked with a wide array of receptors offers a platform to regulate platelet responsiveness, thrombotic propensity, inflammatory disposition, and immune reactivity under diverse pathophysiological conditions.
Madhumita Chatterjee, Meinrad Gawaz
doaj   +1 more source

Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition

Blood Advances, 2023
Abstract Platelet glycoprotein VI (GPVI) is attracting interest as a potential target for the development of new antiplatelet molecules with a low bleeding risk. GPVI binding to vascular collagen initiates thrombus formation and GPVI interactions with fibrin promote the growth and stability of the thrombus.
Philippe Billiald, Alexandre Slater, Martin Welin, Joanne C. Clark, Stéphane Loyau, Martine Pugnière, Isabella G. Jiacomini, Nadia Rose, Kristell Lebozec, Elie Toledano, Déborah François, Steve P. Watson, Martine Jandrot-Perrus   +12 more
openaire   +2 more sources

CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo [PDF]

, 2009
Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells.
Beauchemin, N, Chand, R, Jackson, D, Liu, Y, Ni, H, Nieswandt, B, Oates, L, Reheman, A, Wee, J, Wong, C, Yip, C   +10 more
core  

Sex‐specific predictive value of reticulated platelets in coronary artery disease: A systematic review and meta‐analysis

European Journal of Clinical Investigation, Volume 55, Issue 10, October 2025.
This meta‐analysis of 1835 patients (527 females, 1308 males) shows that elevated RPs are significant predictors of MACCE in both sexes (males: OR 1.99, 95% CI 1.3–3.05; females: OR 2.29, 95% CI 1.31–3.99). Elevated RPs are more strongly associated with cardiovascular death in females (OR 3.29, 95% CI 1.69–6.40) compared to males (OR 2.19, 95% CI .98–4.
Sebastien Elvinger, Stephanie G. Kuehne, Andrea Patrignani, Maximilian Tscharre, Matthias Freynhofer, Leor Perl, Ran Kornowski, Francesca Cesari, Rossella Marcucci, Laura Novelli, Isabell Bernlochner, Philip W. Raake, Mauro Chiarito, Dario Bongiovanni   +13 more
wiley   +1 more source

GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease. [PDF]

Eur Heart J Cardiovasc Pharmacother
Abstract Glycoprotein (GP) VI (GPVI) plays a major role in thrombosis but not haemostasis, making it a promising antithrombotic target. The primary role of GPVI on the surface of platelets is a signalling receptor for collagen, which is one of the most potent thrombotic sub-endothelial components that is exposed by atherosclerotic plaque
Slater A, Khattak S, Thomas MR.
europepmc   +3 more sources

A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications [PDF]

, 2015
The components of many signaling pathways have been identified and there is now a need to conduct quantitative data-rich temporal experiments for systems biology and modeling approaches to better understand pathway dynamics and regulation.
Dunster, Joanne L., Fry, Mike J., Gibbins, Jon M., Jones, Chris I., Mazet, Francoise, Tindall, Marcus J., Vaiyapuri, Sakthi   +6 more
core   +1 more source