Results 111 to 120 of about 8,801 (259)

Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2‐SLC7A11 Signaling Pathway

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Gaudichaudione H (GH) effectively activates NRF2 signaling and its target genes, such as SLC7A11, and pharmaceutical activation of NRF2‐SLC7A11 signaling pathway aggravates uptake of cysteine, disturbance of GSH synthesis, depletion of NADPH, and accumulation of disulfide molecules, ultimately leading to the formation of disulfide bonds between ...
Mengjiao Shi, Xinyan Li, Ying Guo, Yinggang Zhang, Jiayi Xu, Liangwen Yan, Rongrong Liu, Hong Wang, Shenkang Tang, Yaping Zhao, Zongfang Li, Yetong Feng, Dongmei Ren, Pengfei Liu   +13 more
wiley   +1 more source

Basic mechanisms of platelet receptor shedding

Platelets, 2017
Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet function in health and disease.
Robert K. Andrews, Elizabeth E. Gardiner
doaj   +1 more source

Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan. [PDF]

PLoS ONE, 2015
Exposure of platelets to collagen triggers the formation of a platelet clot. Pharmacological agents capable of inhibiting platelet activation by collagen are thus of potential therapeutic interest.
Peng Jiang, Stéphane Loyau, Maria Tchitchinadze, Jacques Ropers, Guillaume Jondeau, Martine Jandrot-Perrus   +5 more
doaj   +1 more source

Ibrutinib inhibits platelet integrin αIIbβ3 outside-in signaling and thrombus stability but not adhesion to collagen [PDF]

, 2015
OBJECTIVE: Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia, and mantle cell lymphoma that increases the risk of bleeding among patients. Platelets from
Alexander P. Bye, Alexander R. Stainer, Amanda J. Unsworth, Jonathan M. Gibbins, Michael J. Fry, Oda A, Sakthivel Vaiyapuri   +6 more
core   +1 more source

Enhanced oxygen availability and preserved aggregative function in platelet concentrates stored at reduced platelet concentration

Transfusion, Volume 65, Issue 3, Page 575-587, March 2025.
Abstract Background Storage of platelets as platelet concentrates for transfusion is limited to 7 days in the United Kingdom due to deleterious effects on platelet quality and function that occur over time. Oxygen (O2) availability and sufficient gaseous exchange are known to be essential in maintaining the viability and function of platelets stored ...
Jamie Nash, Dean Pym, A. Davies, Christine Saunders, Chloe George, J. O. Williams, O. Y. Grinberg, Philip E. James   +7 more
wiley   +1 more source

Targeting GPVI

, 2023
Platelets are blood cells that prevent the loss of extensive blood volumes, but also contribute to arterial thrombosis. After a vessel is injured, platelets become activated by the exposed collagen and aggregate together, forming a thrombus. Whilst this is a crucial process in hemostasis, platelets also become activated due to rupture of an ...
openaire   +2 more sources

Engineered Platelets for Cancer Therapy

Aggregate, Volume 6, Issue 2, February 2025.
This review explores the intricate crosstalk between platelets and immune cells within the tumor microenvironment and provides a comprehensive summary of the various types of engineered platelets designed to inhibit tumor growth and prevent postoperative tumor recurrence and metastasis.
Kai Zhang, Hongyang Li, Zhaoyu Ma, Wenbin Zhong, Yongkang Yu, Yanli Zhao   +5 more
wiley   +1 more source

Activation-induced changes in platelet surface receptor expression and the contribution of the large-platelet subpopulation to activation. [PDF]

, 2020
Objective:Platelet surface receptors are also present subcellularly in organelle membranes and can be expressed on the surface upon platelet activation. However, some receptors were reported to be decreased after activation.
Farndale, Richard W, Jung, Stephanie M, Moroi, Masaaki   +2 more
core   +1 more source

Rapid ubiquitination of Syk following GPVI activation in platelets [PDF]

Blood, 2005
AbstractSpleen tyrosine kinase (Syk) activation is a key intermediate step in the activation of platelets by the physiologic agonist collagen. We have found that Syk is rapidly ubiquitinated upon activation of platelets by collagen, collagen-related peptide (CRP), and convulxin.
Satya P. Kunapuli, Jianguo Jin, Patricia G. Quinter, Alexander Y. Tsygankov, Carol Dangelmaier, James L. Daniel   +5 more
openaire   +3 more sources

Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma

Cancer Communications, Volume 45, Issue 2, Page 143-166, February 2025.
Abstract Background The interaction between the metastatic microenvironment and tumor cells plays an important role in metastatic tumor formation. Platelets play pivotal roles in hematogenous cancer metastasis through tumor cell‐platelet interaction in blood vessels. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy distinguished by
Lin‐Li Yao, Wei‐Ting Qin, Li‐Peng Hu, Tie‐Zhu Shi, Jian Yu Yang, Qing Li, Hui‐Zhen Nie, Jun Li, Xu Wang, Lei Zhu, De‐Jun Liu, Yan‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, Xiao‐Mei Yang, Dong‐Xue Li, Xue‐Li Zhang   +16 more
wiley   +1 more source