Results 211 to 220 of about 115,816 (303)
Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin +10 more
wiley +1 more source
Effect of resveratrol on the antioxidant enzyme pathway and alveolar bone loss in experimental periodontitis. [PDF]
Sezgin Y +9 more
europepmc +1 more source
Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice
Denervation induces mitochondrial dysfunction and oxidative stress in skeletal muscle. In PolG(+/mut) mice, denervation led to reduced mitochondrial DNA copy number and a pronounced upregulation of the antioxidant enzyme catalase, despite comparable levels of muscle atrophy, mitochondrial content, and mitochondrial dynamics‐related proteins compared to
Takanaga Shirai +6 more
wiley +1 more source
Bacillus subtilis TO-A suppresses the age-related decline in locomotion in Caenorhabditis elegans. [PDF]
Inomata R, Saito R, Wang D, Shimazaki S.
europepmc +1 more source
Fusarium oxysporum Fo47 primes flax by locally suppressing pathogens in roots and systemically activating antioxidant defences in shoots, offering a sustainable plant protection strategy. ABSTRACT Plants rely on specialised adaptive mechanisms to enhance resistance against environmental stress.
Marta Burgberger +2 more
wiley +1 more source
Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions
Genetic variation determines whether microbial interactions extend or shorten host lifespan via redox homeostasis. This discovery highlights the critical role of host genetics in shaping microbiota‐driven aging, offering a new framework for precision microbiome interventions tailored to individual needs for promoting longevity.
Xusheng Hao +8 more
wiley +1 more source
XIAP down-regulation inhibits RIPK2 ubiquitination-mediated insulin resistance. [PDF]
Zhao C, Zhang Z, Li R, Geng X.
europepmc +1 more source
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao +8 more
wiley +1 more source
Antiparasitic Activity of Silver Nanoparticles Synthesized from <i>Artemisia cina</i> Aqueous Extract Against <i>Haemonchus contortus</i>. [PDF]
Hernández Guerrero LI +7 more
europepmc +1 more source
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu +5 more
wiley +1 more source

