Results 231 to 240 of about 29,098 (325)

RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling

iMeta, EarlyView.
This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou, Weifeng Hong, Songhua Cai, Dandan Guo, Zhiping Yan, Jinyu Zhu, Yang Shen, Juncheng Wan, Xudong Qu, Wen Zhang, Runkang Zhao, Zhao Xie, Zhongji Chen, Tong Jiang, Yaling Lin, Wenlong Jia, Ling Wang, Zhao Huang, Xuexin Li, Bufu Tang   +19 more
wiley   +1 more source

GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis. [PDF]

Cancer Immunol Immunother
Kłopotowska M, Baranowska I, Hajduk S, Jurga A, Leśniowska N, Łaźniewski M, Granica M, Krawczyk M, Dziewicka M, Graczyk A, Słupski J, Zagożdżon R, Plewczynski D, Winiarska M, Bajor M.   +14 more
europepmc   +1 more source

Cold atmospheric plasma combined with nanoparticles in cancer therapy

Interdisciplinary Medicine, EarlyView.
Cold atmospheric plasma (CAP) generates a range of reactive oxygen and nitrogen species (RONS), including singlet oxygen (1O2), hydrogen peroxide (H2O2), hydroxyl radicals (·OH), nitrate (NO3− ${{\text{NO}}_{3}}^{-}$), and nitrite (NO2− ${{\text{NO}}_{2}}^{-}$), which induce oxidative stress and apoptosis in cancer cells.
Yunhao Wang, Fei Cao, Gbenga A. Martins, Qiujie Fang, Yifan Lin, Zhaowei Chen, Guojun Chen, Zhitong Chen   +7 more
wiley   +1 more source

The role of glutathione peroxidase 4 in neuronal ferroptosis and its therapeutic potential in ischemic and hemorrhagic stroke

Brain Research Bulletin
Ferroptosis is a type of cell death that depends on iron and is driven by lipid peroxidation, playing a crucial role in neuronal death during stroke. A central element in this process is the inactivation of glutathione peroxidase 4 (GPx4), an antioxidant
Chao Wei
doaj  

Ferroptosis and bone health: bridging the gap between mechanisms and therapy. [PDF]

Front Immunol
Xiao R, Han Z, Jia P, Li P, Gong M, Cai Y, Pang L, Ye X, Jin S.   +8 more
europepmc   +1 more source

Monotropein Induced Ferroptosis to Alleviate the Progression of Hepatocellular Carcinoma via Regulating Nrf2/HO‐1/GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) exhibits a high global morbidity rate and ranks as the fourth leading cause of cancer‐related mortality worldwide. In response to the urgent need for effective HCC treatments, naturally occurring, botanical‐driven compounds have gained increasing attention.
Bing Shi, Yan‐Ping Li, Zhuo Gan, Pan Chen   +3 more
wiley   +1 more source

Inhibitory effects of herbal monomers on ferroptosis in renal fibrosis: a review and mechanistic study. [PDF]

Front Pharmacol
Liu K, Yu M, He Y, Wang T, Li G, Wang L, Zhong X.   +6 more
europepmc   +1 more source

Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO‐1 Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Skeletal muscle ischaemia/reperfusion (I/R) injury remains a clinically significant condition characterized by muscular dystrophy. Although ozone therapy has shown protective potential against I/R injury in animal models of various organs including skeletal muscle, its precise mechanistic underpinnings require further elucidation.
Hui‐Zhuang Guo, Sheng‐Long Yu, Han‐Wei Chen   +2 more
wiley   +1 more source

Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC. [PDF]

Cell Death Dis
Yue X, Xiang Z, Yi Y, Wang X, Zhou W, Wu W, Qin W, Zhao Y, Bu X, Peng Z.   +9 more
europepmc   +1 more source

Mechanistic Insights Into hsa_circ_0005654‐Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the molecular mechanism by which hsa_circ_0005654 aggravates diabetic foot ulcers (DFUs) by promoting ferroptosis. A DFU rat model was established, and lentiviral vectors interfering with circ_0005654 and IGF2BP2 expression were injected into DFU rats by tail vein.
Chun‐Meng Li, Xiang‐Jian Zheng, Shang‐Shang Xie, De‐Yong Lin, Zi‐Tian Liu   +4 more
wiley   +1 more source