Results 231 to 240 of about 40,571 (376)

Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation

Redox Biology
H. Zhang, Jianan Pan, Shuying Huang, Xiaonan Chen, A. C. Y. Chang, Changqian Wang, Junfeng Zhang, Huili Zhang   +7 more
semanticscholar   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Ferroptosis inhibitors: mechanisms of action and therapeutic potential. [PDF]

Cell Mol Life Sci
Duo K, Feng X, Tian X, Wang F, Zhao Y, Yu J, Liu Y, He Y, Cai Z.   +8 more
europepmc   +1 more source

Orexin‐A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion [PDF]

Rengzheng Huan, Jiqin Zhang, Jianhe Yue, Sha Yang, Guoqiang Han, Yuan Cheng, Ying Xim Tan   +6 more
openalex   +1 more source

Additional file 4 of The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

, 2023
Zirun Jin, Yuzhuo Yang, Yalei Cao, Qi Wen, Xi Yu, Jianxing Cheng, Qiancheng Zhao, Jiaming Weng, Kai Hong, Hui Jiang, Jing Hang, Zhe Zhang   +11 more
openalex   +1 more source

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source

Ferroptosis in hematological malignancies: molecular mechanisms and therapeutic potential. [PDF]

Cell Oncol (Dordr)
Liu J, Liu R, Miao J, He A.
europepmc   +1 more source

Fermented Cornus officinalis Fruit Protects Against Alcohol-Induced Liver Injury via Regulating Keap1–Nrf2–HO-1/GPX4 Pathway: UPLC-MS/MS Characterization, Network Pharmacology, and Animal Validation

Xian Tao, H. L. Li, Jie Zeng, Mei Fang Peng, Qing Liu, Lan Luo, Yan Wang, Juan Yang, X L Yang, Liangqun LI   +9 more
openalex   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Kaempferol Mitigates CSE-Induced Lung Injury and Epithelial Cell Ferroptosis via Modulating Nrf2/NCOA4/GPx4 Axis. [PDF]

J Cell Mol Med
Jin F, Xing Y, Li S, Yi Z, Wu A, Li X.
europepmc   +1 more source