Results 251 to 260 of about 29,098 (325)

Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is the most common and serious complication of diabetes mellitus. Currently, there is a lack of safe and effective preventive strategies for DKD. The study aimed to explore the preventive effects and potential mechanisms of berberine (BBR) against DKD.
Kun Gao, Yunhua Liu, Kun Li, Lin Liu, Yanmo Cai, Xinxue Zhang, Zongjiang Zhao   +6 more
wiley   +1 more source

Mechanism of LINC00958 in ferroptosis of breast cancer through the SRSF1/GPX4 axis. [PDF]

Hereditas
Wang S, Liu X, Hou X, Sun W, Chen J, Cao Y, Cheng H.   +6 more
europepmc   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway. [PDF]

Sci Rep
Zhang J, He S, Wu K, Wei Y, Li C, Zhu Q, Lian S, Wang L, Wan F, Peng F, Zhang J, Chen Z, Zhang X.   +12 more
europepmc   +1 more source

Positron Emission Tomography/Computed Tomography Imaging‐Guided Polydopamine Nanoparticles Attenuate Foam Cell Ferroptosis for Targeted Antiatherosclerotic Therapy

Small Science, EarlyView.
Folate‐ and arginine‐modified polydopamine nanoparticles (FPLG NPs) are designed for the specific targeting of atherosclerotic foam cells. These nanoparticles combat ferroptosis by scavenging reactive oxygen species, regulating iron/lipid metabolism, and upregulating the GPX4/NRF2 pathway. Using chelator‐free 68Ga‐labeling, positron emission tomography/
Ximei Dai, Zhiyue Wang, Jiaqi Lu, Yutong Xu, Xingji Liu, Jianchen Qi, Tao Zheng, Feng Wang, Guangming Lu, Longjiang Zhang, Jie Sheng, Guifen Yang   +11 more
wiley   +1 more source

Aerosol inhalation of dimeric artesunate phospholipid-conjugated liposomes ameliorates inflammation, fibrosis, and ferroptosis in neonatal mice with hyperoxia-induced lung injury. [PDF]

Front Pharmacol
Guan R, Chen Y, Yu Q, Yu B, Chen S, Jia S, Wang H, Cheng H, Tian Z.   +8 more
europepmc   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Folic Acid Ameliorates Neuronal Ferroptosis in Aging by Up-Regulating SLC7A11-GSH-GPX₄ Antioxidant Pathway and Increasing Cystine Levels. [PDF]

Int J Mol Sci
Wang Y, Zhang J, Wang Z, Ren Q, Li Z, Huang G, Li W.   +6 more
europepmc   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

VIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan, Wangzheqi Zhang, Yan Liao, Chenglong Zhu, Xiaojing Guo, Zui Zou, Mi Li   +6 more
wiley   +1 more source