Results 261 to 270 of about 29,098 (325)

A comprehension and systematic insight into the interaction between ferroptosis and virus infection: The implications of mechanisms and strategies. [PDF]

Virulence
Niu S, Deng Y, Yang Y, Wang J, Fang C, Zhou Y, Dai H.   +6 more
europepmc   +1 more source

Targeting KDM1A suppresses G6PD expression to induce oxidative stress and ferroptosis in TP53‐mutated liver cancer

VIEW, EarlyView.
TP53‐mutant HCC is aggressive and often resistant to treatment. In this study, we found that KDM1A is highly expressed in TP53‐mutant HCC and promotes tumor growth while preventing ferroptosis by activating the pentose phosphate pathway (PPP). Targeting KDM1A, especially in combination with sorafenib, may offer a promising therapeutic strategy for this
Songling Li, Wenyun Guo, Yifei Qian, Linfeng Li, Qianyu Li, Zijun Zhu, Wenli Qin, Wang Li, Yunfeng Yuan, Wei‐Qiang Gao, Yanfeng Liu   +10 more
wiley   +1 more source

Ferroptosis and Metabolic Dysregulation: Emerging Chemical Targets in Cancer and Infection. [PDF]

Molecules
Pawłowska M, Nuszkiewicz J, Jarek DJ, Woźniak A.   +3 more
europepmc   +1 more source

Superoxide Activates Ferroptosis via the Haber‐Weiss Reaction and Enhances Age‐Related Macular Degeneration

Aging Cell, EarlyView.
Superoxide activates ferroptosis through the Haber‐Weiss reaction and contributes to the development of age‐related macular degeneration. MnSOD‐depleted RPE cells are susceptible to blue light‐induced ferroptosis. MnSOD deficiency promotes Hsp70‐driven ubiquitin‐mediated degradation of GPX4.
Ying Huang, Zhenxing Zhou, Mengjia Huan, Qi Guo, Xiaoqian Zhang, Ruiqi Lu, Lushu Chen, Xiumiao Li, Jin Yao, Qin Jiang, Yong Xu   +10 more
wiley   +1 more source

SLC10A3 regulates ferroptosis of glioblastoma through the STAT3/GPX4 pathway. [PDF]

Sci Rep
Sun Q, Lu H, Yuan F, Zhao Q, Wei Y, Wang R, Chen Q, Liu B.   +7 more
europepmc   +1 more source

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source

The interaction between ferroptosis and myocardial ischemia-reperfusion injury: molecular mechanisms and potential therapeutic targets. [PDF]

Eur J Med Res
Zhang T, Han Y, Wang Y, Wang X, Zhao M, Cheng Z, Zhang S.   +6 more
europepmc   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Sodium-glucose cotransporter 2 inhibitors ameliorate glutathione cysteine ligase modifier-mediated oxidative stress and subsequent ferroptosis in proximal tubules of diabetic kidney disease. [PDF]

Redox Rep
Tsai YC, Huang JC, Yu PS, Kuo MC, Wu LY, Chang WA, Hwang SJ, Hsu YL.   +7 more
europepmc   +1 more source