Results 271 to 280 of about 29,098 (325)

A predictive serum miRNA signature impacts diffuse large B‐cell lymphoma cell viability via inhibition of EGLN1 and TXNRD1 regulators of ferroptosis

British Journal of Haematology, EarlyView.
Diffuse large B‐cell lymphoma is a heterogeneous and aggressive pathology. MicroRNAs, deregulated in patient tumours and blood, are promising non‐invasive predictive biomarkers for this pathology. We identified the circulating miR‐200c/421/324 signature both predictive of response to R‐CHOP and correlated with PFS.
Giulia Regazzo, Giulia Vari, Francesco Marchesi, Ana Belén Díaz Méndez, Marta Di Giuliani, Andrea Sacconi, Francesca Palombi, Valentina Lulli, Frauke Goeman, Mariangela Novello, Martina Tomassi, Elena Papa, Francesco Bertoni, Stefan Hohaus, Andrea Mengarelli, Maria Giulia Rizzo   +15 more
wiley   +1 more source

Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer. [PDF]

Signal Transduct Target Ther
Yu D, Hu H, Zhang Q, Wang C, Xu M, Xu H, Geng X, Cai M, Zhang H, Guo M, Lu D, Xu H, Li L, Zhang X, Shen R, Lin S, Wang Q, Zhang W, Liu S.   +18 more
europepmc   +1 more source

African swine fever virus MGF505-3R facilitates ferroptosis to restrict TBK1-IRF3 pathway. [PDF]

Microbiol Spectr
Niu S, Zhou Y, Fang C, Yang Y, Wang J, Gao S, Dai H.   +6 more
europepmc   +1 more source

TP‐0903 Suppresses Aurora A–PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome‐Derived Cell Line

Cancer Science, EarlyView.
TP‐0903 exerts the antitumor effects through diverse cell‐specific mechanisms, including apoptosis, ferroptosis, and cell cycle disruption. These insights underline the potential of TP‐0903 as a therapeutic agent for hematological malignancies and emphasize the need for further research to fully elucidate the molecular targets of TP‐0903 and optimize ...
Tomoko Kimura‐Hyoda, Mikuri Ryu, Ryosuke Yuta, Saori Fukumoto, Kentaro Hosokawa, Hisayuki Yao, Yoko Yasuda, Koichi Miura, Kaoru Tohyama, Fumio Arai, Takeshi Uchiumi   +10 more
wiley   +1 more source

Biphasic protective effects of macrophage migration inhibitory factor in ischemia/reperfusion-induced acute kidney injury. [PDF]

Commun Biol
Du Y, Feng C, Zhou L, Wang T, Ma H, Liu H.   +5 more
europepmc   +1 more source

Exploring the Therapeutic Potential of MIR‐140‐3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies

Cell Proliferation, EarlyView.
Global landscape. ABSTRACT Osteoarthritis (OA) is a prevalent and debilitating joint disorder that affects millions of individuals worldwide, severely impairing mobility, independence, and quality of life. Emerging evidence suggests that ferroptosis is a critical factor in OA pathogenesis.
Feng Ma, Lexin Wang, Hao Chi, Xinyi Li, Yaoqin Xu, Kexin Chen, Jingfan Zhou, Runqin Yang, Jie Liu, Ke Xu, Xiaoling Yang   +10 more
wiley   +1 more source

Targeting PRMT1-mediated methylation of TAF15 to protect against myocardial infarction by inhibiting ferroptosis via the GPX4/NRF2 pathway. [PDF]

Clin Epigenetics
Huang G, He L, Liang B, Gao M, Huang J, Xia H, Li X, Li H, Ruan Y.   +8 more
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target. [PDF]

Redox Biol
Cao J, Chen X, Chen L, Lu Y, Wu Y, Deng A, Pan F, Huang H, Liu Y, Li Y, Tong X, Du J.   +11 more
europepmc   +1 more source