Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition [PDF]
Bioscience Reports, 2020 Abstract It has been demonstrated from previous studies about the killing effect of dihydroartemisinin (DHA) on glioblastoma, which involves multiple aspects: cytotoxicity, cell cycle arrest and invasion inhibition. DHA has the advantages of low cytotoxicity to normal cells, selective killing effect and low drug resistance, making it one
Renxin Yi +7 more
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Ferroptosis resistance mediated by exosomal release of iron
Molecular & Cellular Oncology, 2020 Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases.
Caitlin W. Brown, Arthur M. Mercurio
doaj +1 more source
Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation of human spermatozoa [PDF]
, 2004 Oxidative stress imbalance potentially leads to damage of the structure of the cell and macromolecules such as plasma membrane components, proteins, and DNA.
Garrido, N. +4 more
core +1 more source
Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy [PDF]
, 2010 Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also predispose the mother and fetus to increased risks of adult cardiovascular disease.
Atamer +50 more
core +1 more source
GPX4-independent ferroptosis—a new strategy in disease’s therapy
Cell Death Discovery, 2022 AbstractFerroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process. Ferroptosis plays an essential role in tumors, degenerative diseases, and ischemia-reperfusion injury.
Tianyu Ma +5 more
openaire +3 more sources
Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury
Nature Communications, 2023 Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferroptosis and the molecular events causing GPX4
Li-Kai Chu +19 more
doaj +1 more source
Gene expression profile of oxidative stress in the lung of inbred mice after intestinal ischemia/reperfusion injury [PDF]
, 2014 PURPOSE:To determine the gene expression profile associated with oxidative stress and antioxidant defense in the lung tissue of mice subjected to intestinal ischemia and reperfusion.METHODS:Twelve male, inbred mice (C57BL/6) were randomly assigned to one
Bertoletto, Eduardo Rodrigues +7 more
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Rat liver antioxidant response to iron and copper overloads [PDF]
, 2014 The rat liver antioxidant response to Fe and Cu overloads (0–60 mg/kg) was studied. Dose- and time-responses were determined and summarized by t1/2 and C50, the time and the liver metal content for half maximal oxidative responses.
Boveris, Alberto Antonio +8 more
core +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina. [PDF]
PLoS ONE, 2015 The purpose of the present study was to investigate the role of glutathione peroxidase 4 (GPx4) in glutamate-induced oxytosis in the retina.For in vitro studies, an immortalized rat retinal precursor cell line R28 was used.
Osamu Sakai +5 more
doaj +1 more source