Results 101 to 110 of about 1,013,409 (339)

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury

Advanced Materials Technologies, EarlyView.
Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar, Anushree Chakravarty, Kimia Asadi Jozani, Brenda Truong, Matana Hendrickson, Ahmed Attia, Muna Sabouny, Anna Basatskaya, Sergi Clotet‐Freixas, Madeleine Ludlow, Alexander Sotra, Dawn S. Y. Lin, Feng Zhang, Boyang Zhang   +13 more
wiley   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Immunologic Corneal Graft Rejection after Administration of Topical Latanoprost: a Report of Two Patients

Journal of Ophthalmic & Vision Research, 2011
Purpose: To report endothelial corneal graft rejection after administration of topical latanoprost eye drops. Case Report: Two eyes of two patients with a history of multiple intraocular procedures prior to penetrating keratoplasty developed endothelial
Kouros Nouri-Mahdavi, Mohammad-Ali Javadi, Mohammad-Reza Jafarinasab   +2 more
doaj  

Long-term prognosis of BK virus-associated nephropathy in kidney transplant recipients

Kidney Research and Clinical Practice, 2018
Background : The long-term prognosis of BK virus-associated nephropathy (BKVAN) in kidney transplant recipients (KTRs) is uncertain. We evaluated the long-term prognosis in KTRs with BKVAN and the clinical significance of BKVAN on post-transplant ...
Woo Yeong Park, Seong Sik Kang, Kyubok Jin, Sung Bae Park, Misun Choe, Seungyeup Han   +5 more
doaj   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Pretransplant Sensitization Against Angiotensin II Type 1 Receptor Is a Risk Factor for Acute Rejection and Graft Loss

American Journal of Transplantation, 2013
The angiotensin II type 1 receptor (AT1R) is an emerging target of functional non‐HLA antibodies (Ab). We examined the potential of determining the degree of presensitization against AT1R as a risk factor for graft survival and acute rejection (AR).
M. Giral, Y. Foucher, A. Dufay, J. V. Huyen, K. Renaudin, A. Moreau, A. Philippe, B. Hegner, R. Dechend, H. Heidecke, S. Brouard, A. Cesbron, S. Castagnet, A. Devys, J. Soulillou, D. Dragun   +15 more
semanticscholar   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Grafted-Marrow-Rejection Mortality Contrasted to Homologous Disease in Irradiated Mice Receiving Homologous Bone Marrow<xref ref-type="fn" rid="FN1">2</xref> [PDF]

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J. J. Trentin
openalex   +1 more source

Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand

Advanced Science, EarlyView.
Bone‐specific endothelial cells (b‐ECs) uniquely express KITLG, which recruits c‐Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (bm‐MSCs) and subsequent ossification.
Xiang Li, Hwan D. Kim, Allen C. Luo, Liyan Gong, Yonglin Zhu, Chin Nien Lee, Xuechong Hong, Christopher L. Sudduth, Michal Ad, Young‐Hyeon An, Mihn Jeong Park, Do‐Gyoon Kim, Arin K. Greene, Bonnie L. Padwa, Nathaniel S. Hwang, Ruei‐Zeng Lin, Juan M. Melero‐Martin   +16 more
wiley   +1 more source